Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Ribonuclease HII


DESCRIPTION:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).

STRUCTURE SIMILARITY:
Belongs to the RNase HII family.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MIEFVYPHTQ LVAGVDEVGR GPLVGAVVTA AVILDPARPI AGLNDSKKLS EKRRLALYEE
        70         80         90        100        110        120
IKEKALSWSL GRAEPHEIDE LNILHATMLA MQRAVAGLHI APEYVLIDGN RCPKLPMPAM
       130        140        150        160        170        180
AVVKGDSRVP EISAASILAK VTRDAEMAAL DIVFPQYGFA QHKGYPTAFH LEKLAEHGAT
       190
EHHRRSFGPV KRALGLAS    

Encoded by rnhB gene


OTHER NAME(S):
ECK0182
JW0178


DESCRIPTION:
RNase HII cleaves RNA in RNA-DNA hybrids . [More information is available at EcoCyc: EG10861].


Nucleic acid sequence

        10         20         30         40         50         60
atgatcgaat ttgtttatcc gcacacgcag ctggttgcgg gtgtggatga agtcggacgc
        70         80         90        100        110        120
gggccgttag ttggcgcggt cgtcaccgct gcggtgatcc ttgacccggc gcgcccgatt
       130        140        150        160        170        180
gccgggctga atgattccaa aaagctgagc gaaaaacgcc gtctggcgct ctatgaagag
       190        200        210        220        230        240
atcaaagaga aagcgttgag ctggagtctg ggccgcgcgg aaccccacga aatcgacgag
       250        260        270        280        290        300
ctgaacattc ttcatgcgac catgctggcg atgcagcgtg ccgtcgctgg gctgcatatt
       310        320        330        340        350        360
gcgccggaat atgtgttgat tgatggtaac cgctgcccga aattaccgat gcctgcgatg
       370        380        390        400        410        420
gctgtggtga aaggcgatag ccgcgtaccg gaaatcagtg ccgcgtctat cctggcgaaa
       430        440        450        460        470        480
gtgacgcgtg acgccgaaat ggcggcgctg gatattgttt tcccgcaata tggttttgcc
       490        500        510        520        530        540
caacacaaag ggtacccaac cgcttttcat ctggaaaaac tggctgaaca cggcgcgacc
       550        560        570        580        590
gaacaccatc ggcgcagctt tgggcctgtc aaacgcgcac tgggacttgc gtcctga

Last modification date: Oct. 2, 2011