Homo sapiens L. (human) [HSA]

FULL NAME: DNA repair protein RAD51 homolog 1


DESCRIPTION:
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

STRUCTURE SIMILARITY:
Belongs to the RecA family. RAD51 subfamily.
Contains 1 HhH domain.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.


PROTEIN TYPE(S):
recombinase


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
homologous recombination (HR)


RELATED DISEASE(S):
breast cancer (BC)


Amino acids sequence

        10         20         30         40         50         60
MAMQMQLEAN ADTSVEEESF GPQPISRLEQ CGINANDVKK LEEAGFHTVE AVAYAPKKEL
        70         80         90        100        110        120
INIKGISEAK ADKILTESRS VARLECNSVI LVYCTLRLSG SSDSPASASR VVGTTGGIET
       130        140        150        160        170        180
GSITEMFGEF RTGKTQICHT LAVTCQLPID RGGGEGKAMY IDTEGTFRPE RLLAVAERYG
       190        200        210        220        230        240
LSGSDVLDNV AYARAFNTDH QTQLLYQASA MMVESRYALL IVDSATALYR TDYSGRGELS
       250        260        270        280        290        300
ARQMHLARFL RMLLRLADEF GVAVVITNQV VAQVDGAAMF AADPKKPIGG NIIAHASTTR
       310        320        330        340
LYLRKGRGET RICKIYDSPC LPEAEAMFAI NADGVGDAKD  

Encoded by RAD51 gene

FULL NAME: RAD51 homolog (S. cerevisiae)


OTHER NAME(S):
BRCC5
HRAD51
HsRad51
HsT16930
RAD51A
RECA


DESCRIPTION:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atggcaatgc agatgcagct tgaagcaaat gcagatactt cagtggaaga agaaagcttt
        70         80         90        100        110        120
ggcccacaac ccatttcacg gttagagcag tgtggcataa atgccaacga tgtgaagaaa
       130        140        150        160        170        180
ttggaagaag ctggattcca tactgtggag gctgttgcct atgcgccaaa gaaggagcta
       190        200        210        220        230        240
ataaatatta agggaattag tgaagccaaa gctgataaaa ttctgacgga gtctcgctct
       250        260        270        280        290        300
gttgccaggc tggagtgcaa tagcgtgatc ttggtctact gcaccctccg cctctcaggt
       310        320        330        340        350        360
tcaagtgatt ctcctgcctc agcctcccga gtagttggga ctacaggtgg aattgagact
       370        380        390        400        410        420
ggatctatca cagaaatgtt tggagaattc cgaactggga agacccagat ctgtcatacg
       430        440        450        460        470        480
ctagctgtca cctgccagct tcccattgac cggggtggag gtgaaggaaa ggccatgtac
       490        500        510        520        530        540
attgacactg agggtacctt taggccagaa cggctgctgg cagtggctga gaggtatggt
       550        560        570        580        590        600
ctctctggca gtgatgtcct ggataatgta gcatatgctc gagcgttcaa cacagaccac
       610        620        630        640        650        660
cagacccagc tcctttatca agcatcagcc atgatggtag aatctaggta tgcactgctt
       670        680        690        700        710        720
attgtagaca gtgccaccgc cctttacaga acagactact cgggtcgagg tgagctttca
       730        740        750        760        770        780
gccaggcaga tgcacttggc caggtttctg cggatgcttc tgcgactcgc tgatgagttt
       790        800        810        820        830        840
ggtgtagcag tggtaatcac taatcaggtg gtagctcaag tggatggagc agcgatgttt
       850        860        870        880        890        900
gctgctgatc ccaaaaaacc tattggagga aatatcatcg cccatgcatc aacaaccaga
       910        920        930        940        950        960
ttgtatctga ggaaaggaag aggggaaacc agaatctgca aaatctacga ctctccctgt
       970        980        990       1000       1010       1020
cttcctgaag ctgaagctat gttcgccatt aatgcagatg gagtgggaga tgccaaagac

tga     

Last modification date: Oct. 2, 2011