Homo sapiens L. (human) [HSA]

FULL NAME: Double-strand break repair protein MRE11A


DESCRIPTION:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.

MISCELLANEOUS:
In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.


STRUCTURE SIMILARITY:
Belongs to the MRE11/RAD32 family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
homologous recombination (HR)
non-homologous end-joining (NHEJ)


RELATED DISEASE(S):
ataxia-telangiectasia-like disorder (ATLD)


Amino acids sequence

        10         20         30         40         50         60
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDILSCAGFV NHFGRSMSVE KIDISPVLLQ KGSTKIALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
       310        320        330        340        350        360
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE RLGNSHQPEK
       370        380        390        400        410        420
PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR HREQKEKTGE EINFGKLITK
       430        440        450        460        470        480
PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT ERGMGEAVQE FVDKEEKDAI EELVKYQLEK
       490        500        510        520        530        540
TQRFLKERHI DALEDKIDEE VRRFRETRQK NTNEEDDEVR EAMTRARALR SQSEESASAF
       550        560        570        580        590        600
SADDLMSIDL AEQMANDSDD SISAATNKGR GRGRGRRGGR GQNSASRGGS QRGRAFKSTR
       610        620        630        640        650        660
QQPSRNVTTK NYSEVIEVDE SDVEEDIFPT TSKTDQRWSS TSSSKIMSQS QVSKGVDFES
       670        680
SEDDDDDPFM NTSSLRRNRR    

Encoded by MRE11A gene

FULL NAME: MRE11 meiotic recombination 11 homolog A (S. cerevisiae)


OTHER NAME(S):
ATLD
HNGS1
MRE11
MRE11B


DESCRIPTION:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgagtactg cagatgcact tgatgatgaa aacacattta aaatattagt tgcaacagat
        70         80         90        100        110        120
attcatcttg gatttatgga gaaagatgca gtcagaggaa atgatacgtt tgtaacactc
       130        140        150        160        170        180
gatgaaattt taagacttgc ccaggaaaat gaagtggatt ttattttgtt aggtggtgat
       190        200        210        220        230        240
ctttttcatg aaaataagcc ctcaaggaaa acattacata cctgcctcga gttattaaga
       250        260        270        280        290        300
aaatattgta tgggtgatcg gcctgtccag tttgaaattc tcagtgatca gtcagtcaac
       310        320        330        340        350        360
tttggtttta gtaagtttcc atgggtgaac tatcaagatg gcaacctcaa catttcaatt
       370        380        390        400        410        420
ccagtgttta gtattcatgg caatcatgac gatcccacag gggcagatgc actttgtgcc
       430        440        450        460        470        480
ttggacattt taagttgtgc tggatttgta aatcactttg gacgttcaat gtctgtggag
       490        500        510        520        530        540
aagatagaca ttagtccggt tttgcttcaa aaaggaagca caaagattgc gctatatggt
       550        560        570        580        590        600
ttaggatcca ttccagatga aaggctctat cgaatgtttg tcaataaaaa agtaacaatg
       610        620        630        640        650        660
ttgagaccaa aggaagatga gaactcttgg tttaacttat ttgtgattca tcagaacagg
       670        680        690        700        710        720
agtaaacatg gaagtactaa cttcattcca gaacaatttt tggatgactt cattgatctt
       730        740        750        760        770        780
gttatctggg gccatgaaca tgagtgtaaa atagctccaa ccaaaaatga acaacagctg
       790        800        810        820        830        840
ttttatatct cacaacctgg aagctcagtg gttacttctc tttccccagg agaagctgta
       850        860        870        880        890        900
aagaaacatg ttggtttgct gcgtattaaa gggaggaaga tgaatatgca taaaattcct
       910        920        930        940        950        960
cttcacacag tgcggcagtt tttcatggag gatattgttc tagctaatca tccagacatt
       970        980        990       1000       1010       1020
tttaacccag ataatcctaa agtaacccaa gccatacaaa gcttctgttt ggagaagatt
      1030       1040       1050       1060       1070       1080
gaagaaatgc ttgaaaatgc tgaacgggaa cgtctgggta attctcacca gccagagaag
      1090       1100       1110       1120       1130       1140
cctcttgtac gactgcgagt ggactatagt ggaggttttg aacctttcag tgttcttcgc
      1150       1160       1170       1180       1190       1200
tttagccaga aatttgtgga tcgggtagct aatccaaaag acattatcca ttttttcagg
      1210       1220       1230       1240       1250       1260
catagagaac aaaaggaaaa aacaggagaa gagatcaact ttgggaaact tatcacaaag
      1270       1280       1290       1300       1310       1320
ccttcagaag gaacaacttt aagggtagaa gatcttgtaa aacagtactt tcaaaccgca
      1330       1340       1350       1360       1370       1380
gagaagaatg tgcagctctc actgctaaca gaaagaggga tgggtgaagc agtacaagaa
      1390       1400       1410       1420       1430       1440
tttgtggaca aggaggagaa agatgccatt gaggaattag tgaaatacca gttggaaaaa
      1450       1460       1470       1480       1490       1500
acacagcgat ttcttaaaga acgtcatatt gatgccctcg aagacaaaat cgatgaggag
      1510       1520       1530       1540       1550       1560
gtacgtcgtt tcagagaaac cagacaaaaa aatactaatg aagaagatga tgaagtccgt
      1570       1580       1590       1600       1610       1620
gaggctatga ccagggccag agcactcaga tctcagtcag aggagtctgc ttctgccttt
      1630       1640       1650       1660       1670       1680
agtgctgatg accttatgag tatagattta gcagaacaga tggctaatga ctctgatgat
      1690       1700       1710       1720       1730       1740
agcatctcag cagcaaccaa caaaggaaga ggccgaggaa gaggtcgaag aggtggaaga
      1750       1760       1770       1780       1790       1800
gggcagaatt cagcatcgag aggagggtct caaagaggaa gagcctttaa atctacaaga
      1810       1820       1830       1840       1850       1860
cagcagcctt cccgaaatgt cactactaag aattattcag aggtgattga ggtagatgaa
      1870       1880       1890       1900       1910       1920
tcagatgtgg aagaagacat ttttcctacc acttcaaaga cagatcaaag gtggtccagc
      1930       1940       1950       1960       1970       1980
acatcatcca gcaaaatcat gtcccagagt caagtatcga aaggggttga ttttgaatca
      1990       2000       2010       2020       2030       2040
agtgaggatg atgatgatga tccttttatg aacactagtt ctttaagaag aaatagaaga

taa     

Last modification date: Oct. 2, 2011