Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA mismatch repair protein spellchecker 1


DESCRIPTION:
Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MQAKATDSRQ EPTLNMDTNA RRNFIKFHAK LGEKPATTVR FFDHTDRYTV HGSDDCELVA
        70         80         90        100        110        120
KIVYKSTAFI GALLPDDKKE TLQFVSMSKG NFELAVRELL LVRNYRVEVY VKNSSDWEIE
       130        140        150        160        170        180
YRGSPGNLLQ FEDILFSNKE VLVGNSIISL LVKLDGGGQR RVGVASVEQN DCKFQLLEFL
       190        200        210        220        230        240
DDDFFTELEA TVVLLGPKEC LLPSIEGEYS AVKTLLDRNG VMITMPKKSG DNDLLQDLNR
       250        260        270        280        290        300
LLRFAKGQQE DATGLKELQL QLASNALKTA IKYLDLVNDA GNLGHYEIKQ LDLNRFVHLD
       310        320        330        340        350        360
SAAVAALNIM PKPGTHPSMP SYRWQSVLGV LDHCRTPQGH RLMGQWVKQP LRSRNILNDR
       370        380        390        400        410        420
HNIVQCLLES PDTMETLSLD YLKRIPDILM LTKKLMRRKA NLQDLFRIYQ VILRTPKILK
       430        440        450        460        470        480
VLHELDNSTI ESVICAPFKS FLKDLTGLKQ MVEQVVDFEA IERGEYLVKA SFDSRLMELQ
       490        500        510        520        530        540
QMMTELYSKM EELQFKCSQE LNLDGKNQVK LESVAKLGHH FRITVKDDSV LRKNKNYRIV
       550        560        570        580        590        600
DVIKGGVRFT SDKLEGYADE FASCRTRYEE QQLSIVEEII HVAVGYAAPL TLLNNELAQL
       610        620        630        640        650        660
DCLVSFAIAA RSAPTPYVRP KMLEEGAREL VLEDVRHPCL ELQEHVNFIA NSVDFKKEEC
       670        680        690        700        710        720
NMFIITGPNM GGKSTYIRSV GTAVLMAHIG AFVPCSLATI SMVDSILGRV GASDNIIKGL
       730        740        750
STFMVEMIET SGIIRVSRET KETKFTYFIQ DF  

Encoded by spel1 gene

FULL NAME: spellchecker1


OTHER NAME(S):
BG:DS01068.9
CG4215
Dmel\CG4215
Msh2
spel
spel-1
SPEL1


Nucleic acid sequence

        10         20         30         40         50         60
atgcaggcca aagcaaccga cagcaggcag gaacctaccc tgaatatgga cacaaatgcg
        70         80         90        100        110        120
cgtcgcaatt tcatcaaatt ccatgcgaaa ctcggcgaga aacccgcaac tacagtgagg
       130        140        150        160        170        180
ttctttgatc acaccgatcg ctatacggtc cacggcagcg atgactgcga acttgtggcc
       190        200        210        220        230        240
aaaatcgtat acaaatccac ggccttcatt ggcgcactgc tgccggatga caaaaaggag
       250        260        270        280        290        300
actcttcagt ttgtgtccat gtccaagggc aacttcgagc tggctgtgcg cgagctgctc
       310        320        330        340        350        360
ttggtgcgca attaccgggt tgaggtgtac gttaagaatt ccagcgattg ggaaatcgag
       370        380        390        400        410        420
taccgcggat cacccggcaa tctgctgcaa ttcgaggaca tcctgttctc caataaggag
       430        440        450        460        470        480
gttttggtcg ggaacagcat catctcgctg ctggttaagc tcgatggcgg tggccagcgg
       490        500        510        520        530        540
cgtgtgggtg tggccagcgt cgagcagaac gactgcaagt tccagctgct tgaattccta
       550        560        570        580        590        600
gacgatgact tcttcaccga actggaggcc accgtggtcc tgctcggacc aaaggagtgc
       610        620        630        640        650        660
ctgctgccaa gcatcgaggg cgaatatagt gctgtgaaga cgctgctcga cagaaatggt
       670        680        690        700        710        720
gtcatgatta cgatgcccaa gaagagcggc gacaacgatc tgctgcagga tctaaatcgt
       730        740        750        760        770        780
cttttgcgtt tcgccaaggg acaacaggag gatgccacgg gcttgaagga actccagctt
       790        800        810        820        830        840
cagctggcct ccaacgcact gaagaccgcc atcaagtacc tggacctggt caatgacgcc
       850        860        870        880        890        900
ggaaatctgg gacactacga gatcaagcaa ctggacctaa accgctttgt ccacttagat
       910        920        930        940        950        960
tctgctgccg tggctgcgtt aaacatcatg ccaaagccag gcacacatcc atctatgccc
       970        980        990       1000       1010       1020
tcgtatcgct ggcaaagcgt cttgggcgtg ctggatcatt gccgtacacc acagggacat
      1030       1040       1050       1060       1070       1080
cgcctgatgg gtcagtgggt taagcagcca ctgcgaagcc gaaatatcct caatgatcgt
      1090       1100       1110       1120       1130       1140
cataacattg tccagtgcct actcgaatct ccagacacaa tggagacttt gagtctcgat
      1150       1160       1170       1180       1190       1200
tatctgaagc gtattccgga tattcttatg ctaactaaga agctaatgcg acgcaaagct
      1210       1220       1230       1240       1250       1260
aatttgcaag atttattccg catttaccag gtcattctga ggaccccgaa aattcttaaa
      1270       1280       1290       1300       1310       1320
gttctgcatg agctcgataa ttcaacgatc gaaagtgtga tctgtgcgcc ttttaaaagc
      1330       1340       1350       1360       1370       1380
ttcctaaagg atctgacagg gctcaagcag atggtcgagc aggtggttga ctttgaggcc
      1390       1400       1410       1420       1430       1440
atcgaaaggg gcgagtatct ggtgaaggct tcgtttgaca gccgtctaat ggagctgcag
      1450       1460       1470       1480       1490       1500
cagatgatga cggagcttta ttcgaaaatg gaagagttgc agttcaaatg cagtcaggaa
      1510       1520       1530       1540       1550       1560
ttgaatttgg atggcaaaaa ccaggtgaag ctggaaagtg tggccaaatt gggacaccac
      1570       1580       1590       1600       1610       1620
ttccgcatca ccgtgaaaga tgattccgtg ctgcgcaaga acaagaacta tcgcatcgtg
      1630       1640       1650       1660       1670       1680
gatgtgatca agggcggtgt tcgcttcaca tccgataagc tggagggcta cgccgatgag
      1690       1700       1710       1720       1730       1740
tttgccagct gccgcactcg ctacgaggaa cagcagctgt ccattgtgga ggagataatt
      1750       1760       1770       1780       1790       1800
catgtggctg taggatatgc tgccccgctc actttgctta acaacgagct tgcccagctc
      1810       1820       1830       1840       1850       1860
gactgtttgg tgagctttgc tatcgccgcc cgcagtgcgc ccactcccta tgtgcggccc
      1870       1880       1890       1900       1910       1920
aaaatgctgg aggaaggtgc tcgcgagctg gttctcgagg atgtgcgtca tccttgtttg
      1930       1940       1950       1960       1970       1980
gagctgcagg agcatgtcaa cttcatagct aacagtgttg actttaagaa agaggagtgc
      1990       2000       2010       2020       2030       2040
aacatgttta taatcacggg acccaacatg ggtggcaaga gcacttatat tcgctctgtg
      2050       2060       2070       2080       2090       2100
ggtaccgctg tgctaatggc ccatatcgga gcttttgtac cctgcagctt ggccacaatc
      2110       2120       2130       2140       2150       2160
agcatggtgg actccattct tggaagagtg ggagctagtg acaacatcat caagggtttg
      2170       2180       2190       2200       2210       2220
agcacattta tggtcgagat gattgaaaca tctggcataa taagggtgag tagagaaaca
      2230       2240       2250
aaagaaacta aatttactta ctttatccag gacttttaa  

Last modification date: Oct. 2, 2011