Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: Probable DNA mismatch repair protein Msh6


DESCRIPTION:
Involved in post-replicative DNA-mismatch repair.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSKKLNTSVG GTPTNTLLNY FSKSPAFDKK KLTPSVKTDP DASKSEKENL QNQQPKVKDG
        70         80         90        100        110        120
KKEASKPAAK RKLPISDDEP ASGQRKRKRI VQPESDSEPE MEVTKSEDDF SDCASDYEPD
       130        140        150        160        170        180
ENEASDDSVS SGAEEVSPSE NDMSVDSPTP KKSRKKSKIL NNNNNNEPSS KKVKLESTIQ
       190        200        210        220        230        240
LAEGATFQEK LKNLQSNAKQ DASYDDIVTN TSNLDEPVVW PHQKLEFLQP DKIKDKEGRR
       250        260        270        280        290        300
PDHPDYDKST LHVPEKFLNG LSPGVRQWWV LKSDNYDCVL FFKVGKFYEL YHMDADVGVN
       310        320        330        340        350        360
ELGFTYMRGE FAHSGFPEIS FDKMSTILVD RGFKVARVEQ TETPDMMTER CKRIKATKFD
       370        380        390        400        410        420
KVVAREICQI TNRGTQVFGS QCKIGPNHQP NYMLAIVEKD EGTCSRYGVC FIDTSIGDFH
       430        440        450        460        470        480
LGEFEDDKNC SRLLTLVSHH MPVLFLNEKS ALSQRTQQIV RTVLGGILKE PVPGNGKHAC
       490        500        510        520        530        540
SAEKTLKLLA ERYYAGPGSD DNWPLVLRTM QSDMDHLGLT PNDNYKLALK ALGQCIFFIH
       550        560        570        580        590        600
KCKLEPKVLP MARYQLYVPP DQLADAKPAV ASTLRRSHMV LDATTLSNLR IIGEEHSLLS
       610        620        630        640        650        660
TLDHCCTKFG KRLLHHWLCA PSCDVSVIKE RQDAIGELIR MPTELQEVRA LLAPMPDFER
       670        680        690        700        710        720
NLAQIHLFGN KQIKQMDHPD SRAILFEEKL YNKQKLQGFM AVLKGFNDLT KLPTMFHQCK
       730        740        750        760        770        780
TTLLKRITQL PESGGSFPDL SKELQYFATA FDHDAAAKTG VIAPQAGMDA EYDAAMDSIG
       790        800        810        820        830        840
EVEKRLKTYL VEQERHFGCR ITYFGSDKKR YQLDVPESHA SKANKSYTLE GQTKGKKPSR
       850        860        870        880        890        900
RYTTAETRAL LKDMQHAEDT RNMVLKDLAR RLFEKFSNHY DQWKQCIDCV ANLDVLGSLA
       910        920        930        940        950        960
EYAGQQMVIC VPELVSDADQ PFIQLEEGYH PCANASTYIP NGLELGTASE APLSLLTGPN
       970        980        990       1000       1010       1020
MGGKSTLMRE VGLLVIMAQI GAHIPAASCR LSLVDRIFTR LGAQDDILAG HSTFLVELNE
      1030       1040       1050       1060       1070       1080
TSLILKHATC HSLVLLDELG RGTATYDGTA IAASVVNFLA NLKCRTLFST HYHNLIDFFH
      1090       1100       1110       1120       1130       1140
NDKRITLGHM ACMVENEDNA DPTQETVTFL YKYTAGACPK SYGFNAAKLA GMPQGIIKRA
      1150       1160       1170       1180       1190
YELSKKVEAI ALQRKITAKI VAATAGNEDT KKEKINALKD LLKQLKMCQV 

Encoded by Msh6 gene


OTHER NAME(S):
CG7003
Dmel\CG7003


Nucleic acid sequence

        10         20         30         40         50         60
atgtccaaga agttaaacac cagcgtgggc gggacgccca caaacacgct actaaattac
        70         80         90        100        110        120
ttttccaagt cgccagcttt cgacaaaaag aaattgactc ctagcgtgaa aacagatccc
       130        140        150        160        170        180
gatgcatcca agagcgaaaa ggagaatctc cagaaccagc agccaaaagt gaaggatggt
       190        200        210        220        230        240
aagaaagagg cttccaagcc ggcggccaag aggaagttgc ccatttccga cgatgagccg
       250        260        270        280        290        300
gccagtggtc aacgcaagcg gaagcgcatc gttcagccgg aatcggacag tgagccggaa
       310        320        330        340        350        360
atggaggtaa ccaagtcgga ggacgacttc tccgattgcg cctccgacta cgaaccggat
       370        380        390        400        410        420
gagaatgaag ccagcgatga tagcgttagc agcggcgcgg aggaggtgtc gcctagcgag
       430        440        450        460        470        480
aacgacatgt ccgtggacag tccgacaccc aagaaatcgc gcaaaaagtc taagattctg
       490        500        510        520        530        540
aataacaaca ataacaatga gccatcgagc aagaaggtca agctagagtc gaccatccag
       550        560        570        580        590        600
ttggccgagg gtgcaacctt tcaagaaaag ctgaagaacc tgcagagcaa tgccaagcag
       610        620        630        640        650        660
gatgcttcct acgatgatat cgtgaccaac acgtccaatc tggatgagcc cgttgtttgg
       670        680        690        700        710        720
ccgcaccaga aactagagtt cctgcaaccg gacaagatca aggacaagga gggaagacgt
       730        740        750        760        770        780
ccagatcatc cggactacga taagagcacc ttgcatgtgc cggagaagtt cctcaatggc
       790        800        810        820        830        840
ctgtcgccgg gagttcgaca gtggtgggtc cttaagtcgg acaactatga ctgcgtcttg
       850        860        870        880        890        900
ttttttaaag tcggcaagtt ctatgaactg tatcacatgg atgcggatgt gggcgtcaac
       910        920        930        940        950        960
gagctgggct tcacttacat gcgcggcgag tttgctcact ccggtttccc ggagatatcc
       970        980        990       1000       1010       1020
ttcgacaaga tgtccaccat tctcgtagac aggggcttca aggtggctcg cgttgagcaa
      1030       1040       1050       1060       1070       1080
acggaaactc cagatatgat gactgagcgc tgcaagcgga tcaaggccac caagttcgac
      1090       1100       1110       1120       1130       1140
aaagtggtgg cccgcgagat ctgccagatc accaatcgtg gcacccaggt ctttggctca
      1150       1160       1170       1180       1190       1200
cagtgcaaga tcgggccgaa tcatcagccc aactatatgt tggccatagt ggagaaggat
      1210       1220       1230       1240       1250       1260
gagggaactt gtagccggta tggagtgtgc ttcatagaca cctccattgg tgactttcat
      1270       1280       1290       1300       1310       1320
ttgggtgagt ttgaagacga caagaactgt tcccgcctcc tcaccctggt gtcacatcat
      1330       1340       1350       1360       1370       1380
atgccagtat tgttccttaa tgagaaatcc gctctgagcc agcgaaccca gcaaattgtg
      1390       1400       1410       1420       1430       1440
cgcactgtgc tgggtggaat ccttaaggag cccgttcccg gcaacggaaa gcatgcctgc
      1450       1460       1470       1480       1490       1500
agtgccgaaa aaacactgaa acttctggcg gaacgttact atgctggacc cggatccgat
      1510       1520       1530       1540       1550       1560
gacaactggc cattggtgct gcgcaccatg caatccgata tggatcattt gggcctgaca
      1570       1580       1590       1600       1610       1620
ccaaatgata attacaagct agcccttaaa gctctcggcc agtgcatctt ctttatccat
      1630       1640       1650       1660       1670       1680
aagtgcaagc tggagcccaa ggtgctgccc atggcgcgtt atcagctata tgtgccgccc
      1690       1700       1710       1720       1730       1740
gatcagctgg cggatgccaa gccggcggta gcatccacat tgagacgctc ccacatggta
      1750       1760       1770       1780       1790       1800
ctggatgcca ctactttgtc gaacctcaga attattggtg aggaacactc cttgctctcc
      1810       1820       1830       1840       1850       1860
actttggatc actgctgcac caagttcgga aagcgactgc tgcaccactg gctttgcgct
      1870       1880       1890       1900       1910       1920
ccgagttgcg atgtctcagt catcaaggag cgacaagatg ctattggtga gctaattcga
      1930       1940       1950       1960       1970       1980
atgcccaccg aactgcagga agttcgagct ttgctagctc cgatgcccga tttcgaacga
      1990       2000       2010       2020       2030       2040
aatcttgccc agattcatct atttggcaac aaacagataa agcagatgga ccacccggat
      2050       2060       2070       2080       2090       2100
tcccgggcga ttcttttcga agaaaagcta tataacaagc aaaagctaca gggatttatg
      2110       2120       2130       2140       2150       2160
gccgtactta agggattcaa tgatctaacc aaattgccta cgatgttcca tcagtgcaaa
      2170       2180       2190       2200       2210       2220
acaactttgc ttaagagaat tacccagctg ccggaatcgg gaggctcttt tcccgatcta
      2230       2240       2250       2260       2270       2280
agcaaggagc tacaatattt tgccactgcc tttgatcatg atgcagctgc taaaacgggt
      2290       2300       2310       2320       2330       2340
gtgattgcac cccaagctgg aatggatgct gagtacgatg cggcaatgga ttccataggt
      2350       2360       2370       2380       2390       2400
gaggttgaga aacgcctcaa aacatatctt gtggaacaag agcgacactt tggttgccgc
      2410       2420       2430       2440       2450       2460
attacctatt tcggcagcga caagaaacgt taccaattgg atgtgccaga aagccatgcc
      2470       2480       2490       2500       2510       2520
agcaaggcca ataaatccta caccttggaa ggacaaacta agggaaagaa gccatctcgt
      2530       2540       2550       2560       2570       2580
cgctacacca ctgctgaaac ccgtgcccta ctaaaggaca tgcagcacgc tgaggataca
      2590       2600       2610       2620       2630       2640
aggaacatgg tcctaaaaga tctggcgcgt cgtcttttcg agaagttctc gaatcactac
      2650       2660       2670       2680       2690       2700
gaccagtgga agcaatgcat tgactgcgtc gccaacctgg atgtcctagg ctcactagct
      2710       2720       2730       2740       2750       2760
gaatacgctg gtcaacaaat ggttatctgt gtgccagagc tggtctctga tgcggatcag
      2770       2780       2790       2800       2810       2820
ccgtttatcc aactggagga gggctaccac ccttgcgcaa atgcatccac ctatattccc
      2830       2840       2850       2860       2870       2880
aatggcctgg aattgggcac tgcatcggag gcgccactgt cactactcac tggccccaat
      2890       2900       2910       2920       2930       2940
atgggcggca agagtacgct gatgagagaa gtgggtcttc tcgtaatcat ggcgcaaatt
      2950       2960       2970       2980       2990       3000
ggcgcccaca ttcccgctgc tagttgtcgc ctttcgttgg tggacagaat cttcacgcgc
      3010       3020       3030       3040       3050       3060
ctgggtgctc aagatgacat tctggccggg cacagcacct tccttgtgga gcttaacgaa
      3070       3080       3090       3100       3110       3120
acctcactta ttctcaaaca cgccacatgc cattcgcttg tgctgctcga cgaactcggc
      3130       3140       3150       3160       3170       3180
aggggaaccg ccacatatga tggcacagcg attgctgcct ctgtcgtcaa ctttctggcc
      3190       3200       3210       3220       3230       3240
aatctcaagt gccgcactct gttctccaca cactatcaca atctgattga tttcttccac
      3250       3260       3270       3280       3290       3300
aacgacaaga gaatcacact gggtcacatg gcttgcatgg tggagaatga agacaatgcc
      3310       3320       3330       3340       3350       3360
gatcctaccc aagaaacggt cacgttccta tacaagtata cagccggtgc ttgtcccaaa
      3370       3380       3390       3400       3410       3420
tcgtatggct ttaacgcagc caaattagct ggaatgcctc agggaattat taagcgggcc
      3430       3440       3450       3460       3470       3480
tatgagcttt ccaagaaagt cgaagccatt gctttgcagc gcaaaattac ggccaagatc
      3490       3500       3510       3520       3530       3540
gtagctgcca cagccggaaa cgaagacacc aaaaaggaga aaataaatgc actcaaagat
      3550       3560       3570
ctgctaaagc agttaaaaat gtgccaagtt tag  

Last modification date: Oct. 2, 2011