Mus musculus L. (mouse) [MMU]

FULL NAME: Exonuclease 1


DESCRIPTION:
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.

STRUCTURE SIMILARITY:
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage and in response to agents stalling DNA replication, probably by ATM or ATR (By similarity).


PROTEIN TYPE(S):
5'-3' exonuclease
DNase
RNase


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MGIQGLLQFI QEASEPVNVK KYKGQAVAVD TYCWLHKGAI ACAEKLAKGE PTDRYVGFCM
        70         80         90        100        110        120
KFVNMLLSYG VKPILIFDGC TLPSKKEVER SRRERRQSNL LKGKQLLREG KVSEARDCFA
       130        140        150        160        170        180
RSINITHAMA HKVIKAARAL GVDCLVAPYE ADAQLAYLNK AGIVQAVITE DSDLLAFGCK
       190        200        210        220        230        240
KVILKMDQFG NGLEVDQARL GMCKQLGDVF TEEKFRYMCI LSGCDYLASL RGIGLAKACK
       250        260        270        280        290        300
VLRLANNPDI VKVIKKIGHY LRMNITVPED YITGFIRANN TFLYQLVFDP IQRKLVPLNA
       310        320        330        340        350        360
YGDDVNPETL TYAGQYVGDS VALQIALGNR DVNTFEQIDD YSPDTMPAHS RSHSWNEKAG
       370        380        390        400        410        420
QKPPGTNSIW HKNYCPRLEV NSVSHAPQLK EKPSTLGLKQ VISTKGLNLP RKSCVLKRPR
       430        440        450        460        470        480
NEALAEDDLL SQYSSVSKKI KENGCGDGTS PNSSKMSKSC PDSGTAHKTD AHTPSKMRNK
       490        500        510        520        530        540
FATFLQRRNE ESGAVVVPGT RSRFFCSSQD FDNFIPKKES GQPLNETVAT GKATTSLLGA
       550        560        570        580        590        600
LDCPDTEGHK PVDANGTHNL SSQIPGNAAV SPEDEAQSSE TSKLLGAMSP PSLGTLRSCF
       610        620        630        640        650        660
SWSGTLREFS RTPSPSASTT LQQFRRKSDP PACLPEASAV VTDRCDSKSE MLGETSQPLH
       670        680        690        700        710        720
ELGCSSRSQE SMDSSCGLNT SSLSQPSSRD SGSEESDCNN KSLDNQGEQN SKQHLPHFSK
       730        740        750        760        770        780
KDGLRRNKVP GLCRSSSMDS FSTTKIKPLV PARVSGLSKK SGSMQTRKHH DVENKPGLQT
       790        800        810        820        830
KISELWKNFG FKKDSEKLPS CKKPLSPVKD NIQLTPETED EIFNKPECVR AQRAIFH

Encoded by Exo1 gene

FULL NAME: exonuclease 1


OTHER NAME(S):
5730442G03Rik
Msa


Nucleic acid sequence

        10         20         30         40         50         60
atggggattc aagggttact tcagttcatc caagaagctt ctgaacctgt caacgtgaag
        70         80         90        100        110        120
aagtacaaag gacaggcagt ggctgtggat acctactgtt ggcttcacaa aggggctatt
       130        140        150        160        170        180
gcttgtgctg aaaagctagc caaaggggaa cctacagata ggtatgtagg attttgtatg
       190        200        210        220        230        240
aagtttgtta atatgctgct gtcttatggg gtcaagccga ttctcatatt tgacggatgt
       250        260        270        280        290        300
actctacctt ctaaaaagga agtggagcgg tctcgaagag agagacgaca aagcaacctt
       310        320        330        340        350        360
cttaaaggga agcagcttct tcgagagggc aaagtgtcag aagcccgaga ctgcttcgct
       370        380        390        400        410        420
cgctctatca acatcacgca cgccatggcc cacaaagtaa taaaagctgc tcgggcccta
       430        440        450        460        470        480
ggagtggatt gcctcgtggc tccgtatgaa gctgatgctc agttggccta ccttaacaag
       490        500        510        520        530        540
gctggcatcg tgcaggctgt catcacagag gactctgacc tcctcgcatt tggctgtaag
       550        560        570        580        590        600
aaggtgattt taaaaatgga tcagtttgga aatggactgg aagtggacca ggcacggcta
       610        620        630        640        650        660
ggcatgtgca agcagcttgg ggatgtattc acggaggaga agttccggta catgtgcatt
       670        680        690        700        710        720
ctgtccggct gtgactacct cgcctccctt cgtgggatcg gcttagccaa ggcctgcaaa
       730        740        750        760        770        780
gtgctgagac tggccaataa ccccgatatc gtgaaggtta tcaagaaaat tgggcattat
       790        800        810        820        830        840
ctcaggatga atataacggt gcccgaggat tacatcacag gatttattcg tgccaacaat
       850        860        870        880        890        900
actttcctct accagctcgt gttcgacccc atccaaagga agctggtccc tctgaatgcc
       910        920        930        940        950        960
tacggagatg acgttaatcc cgaaacactg acttacgctg ggcagtacgt cggtgactct
       970        980        990       1000       1010       1020
gtagctcttc agatcgccct tggaaataga gatgtaaata cttttgaaca gattgatgac
      1030       1040       1050       1060       1070       1080
tacagtccag acaccatgcc agcccactca agaagccaca gctggaatga gaaagcaggt
      1090       1100       1110       1120       1130       1140
cagaaaccac ctggtaccaa cagcatttgg cacaagaatt attgtcctag acttgaggtg
      1150       1160       1170       1180       1190       1200
aacagtgtct cccacgctcc tcaactgaag gaaaagccaa gcactttggg ccttaaacaa
      1210       1220       1230       1240       1250       1260
gtgattagta ctaaagggtt aaatcttccc aggaagtctt gtgtgttgaa aagaccaaga
      1270       1280       1290       1300       1310       1320
aatgaagcgc tggctgaaga tgacctgttg agccagtatt cgtcagtttc aaagaagatc
      1330       1340       1350       1360       1370       1380
aaggaaaatg gctgtgggga tggcacatca cctaactctt ctaaaatgtc caagtcctgc
      1390       1400       1410       1420       1430       1440
cccgattctg ggactgctca caagacagat gcacacaccc cgtctaagat gaggaataaa
      1450       1460       1470       1480       1490       1500
tttgcaacgt tcttacagag gaggaatgaa gaaagcggtg cagtcgtggt tccagggacc
      1510       1520       1530       1540       1550       1560
agaagcaggt ttttttgcag ttctcaggat tttgacaatt tcataccaaa aaaagaaagc
      1570       1580       1590       1600       1610       1620
ggccagcctc taaatgaaac tgtggccact ggcaaagcca ccaccagcct cctcggggca
      1630       1640       1650       1660       1670       1680
ctggactgtc cagacacgga aggccacaag ccggttgatg caaatgggac gcacaatctg
      1690       1700       1710       1720       1730       1740
agctctcaga ttccaggcaa tgcagctgtg tctcctgagg atgaggctca gtcctctgag
      1750       1760       1770       1780       1790       1800
accagcaaac tcttgggggc catgtcccca cccagtctgg ggacactaag aagctgtttc
      1810       1820       1830       1840       1850       1860
agttggtctg gcactctcag ggaattttct cgaactccaa gtccctcagc aagcactaca
      1870       1880       1890       1900       1910       1920
ttgcagcagt tccggagaaa gagcgacccc cctgcctgtc ttcctgaggc ctctgccgtg
      1930       1940       1950       1960       1970       1980
gtcactgaca ggtgcgactc aaagagcgag atgctgggtg agacgtctca gcccttgcac
      1990       2000       2010       2020       2030       2040
gagctgggct gctcctcgcg gtctcaggaa agcatggact cctcgtgcgg cctaaacacg
      2050       2060       2070       2080       2090       2100
tcgagcctgt cccagccttc cagtagggat tcaggttcag aggagtcgga ttgtaacaat
      2110       2120       2130       2140       2150       2160
aagtcacttg ataatcaagg ggaacagaac tccaagcaac acttacctca cttttcaaag
      2170       2180       2190       2200       2210       2220
aaagacggac ttagacggaa caaggttcct gggctctgta ggtctagttc tatggactct
      2230       2240       2250       2260       2270       2280
ttttctacaa ccaagatcaa gcccctggtg cctgccaggg tcagtggcct gagcaagaag
      2290       2300       2310       2320       2330       2340
tcaggaagca tgcagacgag aaaacaccat gatgtggaga acaagccagg cctacagacg
      2350       2360       2370       2380       2390       2400
aagatcagcg agctctggaa aaactttggg tttaaaaaag attctgaaaa gcttccttct
      2410       2420       2430       2440       2450       2460
tgtaagaagc ccctgtctcc agtcaaggac aatatccaac tcactccaga gacagaagat
      2470       2480       2490       2500       2510
gagatcttta acaagcccga gtgtgtacgc gctcagagag caatatttca ctaa

Last modification date: Oct. 2, 2011