Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase alpha subunit B


DESCRIPTION:
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase alpha subunit B family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated in a cell cycle-dependent manner, in G2/M phase.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSASAQQLAE ELQIFGLDCE EALIEKLVEL CVQYGQNEEG MVGELIAFCT STHKVGLTSE
        70         80         90        100        110        120
ILNSFEHEFL SKRLSKARHS TCKDSGHAGA RDIVSIQELI EVEEEEEILL NSYTTPSKGS
       130        140        150        160        170        180
QKRAISTPET PLTKRSVSTR SPHQLLSPSS FSPSATPSQK YNSRSNRGEV VTSFGLAQGV
       190        200        210        220        230        240
SWSGRGGAGN ISLKVLGCPE ALTGSYKSMF QKLPDIREVL TCKIEELGSE LKEHYKIEAF
       250        260        270        280        290        300
TPLLAPAQEP VTLLGQIGCD SNGKLNNKSV ILEGDREHSS GAQIPVDLSE LKEYSLFPGQ
       310        320        330        340        350        360
VVIMEGINTT GRKLVATKLY EGVPLPFYQP TEEDADFEQS MVLVACGPYT TSDSITYDPL
       370        380        390        400        410        420
LDLIAVINHD RPDVCILFGP FLDAKHEQVE NCLLTSPFED IFKQCLRTII EGTRSSGSHL
       430        440        450        460        470        480
VFVPSLRDVH HEPVYPQPPF SYSDLSREDK KQVQFVSEPC SLSINGVIFG LTSTDLLFHL
       490        500        510        520        530        540
GAEEISSSSG TSDRFSRILK HILTQRSYYP LYPPQEDMAI DYESFYVYAQ LPVTPDVLII
       550        560        570        580        590
PSELRYFVKD VLGCVCVNPG RLTKGQVGGT FARLYLRRPA ADGAERQSPC IAVQVVRI

Encoded by POLA2 gene

FULL NAME: polymerase (DNA directed), alpha 2 (70kD subunit)


OTHER NAME(S):
FLJ21662
FLJ37250


Nucleic acid sequence

        10         20         30         40         50         60
atgtccgcat ccgcccagca gctggcggag gagctgcaga tcttcggcct agactgcgag
        70         80         90        100        110        120
gaggctctaa ttgagaaatt ggtagagctt tgtgttcagt atggacagaa tgaggaggga
       130        140        150        160        170        180
atggtaggcg agcttatagc cttctgcacc agcacacata aagttggcct tacctcagag
       190        200        210        220        230        240
atcctgaact cttttgagca tgagtttctg agcaaaagat tatcgaaagc caggcatagt
       250        260        270        280        290        300
acctgcaagg acagtggcca tgcaggagct agagacattg tttccattca agagctaatt
       310        320        330        340        350        360
gaagtggaag aagaagagga aatcctcttg aactcttaca ccacaccttc aaagggttct
       370        380        390        400        410        420
cagaagcgag ctatctctac cccagaaacc cccctaacaa aaaggagtgt gtcaactcgt
       430        440        450        460        470        480
agcccccatc agctactctc accgtcaagt ttctctccaa gtgctactcc ctcccagaaa
       490        500        510        520        530        540
tacaactcac gaagtaaccg aggagaagtg gttacctcct tcggcttagc acagggagta
       550        560        570        580        590        600
tcttggtctg ggagaggagg agctggaaac atcagcctga aggtcttggg atgtccagag
       610        620        630        640        650        660
gcactaactg ggagctacaa atccatgttt cagaagctcc cagacattcg agaagttctg
       670        680        690        700        710        720
acctgtaaga tagaagaact tggcagcgaa ctcaaggaac attacaagat tgaagctttc
       730        740        750        760        770        780
actcctttgc tagccccagc acaggagcct gtcactctgc tgggccagat tggctgtgat
       790        800        810        820        830        840
agcaacggga agctgaacaa caagtcagtg attctcgagg gagaccggga acattcctcg
       850        860        870        880        890        900
ggtgctcaaa ttccagtgga tttatctgag cttaaggaat attctctgtt tcctggacag
       910        920        930        940        950        960
gttgtaatta tggaaggaat caacaccact ggtaggaaac ttgttgccac caaactctac
       970        980        990       1000       1010       1020
gagggtgtgc cacttccatt ttatcagccc actgaagagg atgcagactt tgagcaaagc
      1030       1040       1050       1060       1070       1080
atggtcctgg ttgcctgtgg accatacacc acatctgaca gcatcacgta tgaccccctg
      1090       1100       1110       1120       1130       1140
cttgacctga ttgctgtcat caaccatgac cggccagatg tctgcatcct gtttggccct
      1150       1160       1170       1180       1190       1200
ttcctggatg ctaagcatga acaggtggag aattgtctac tgacaagtcc atttgaagac
      1210       1220       1230       1240       1250       1260
attttcaagc agtgtctacg aacaattatt gaaggcacaa gaagctccgg ctcccacctt
      1270       1280       1290       1300       1310       1320
gtctttgtcc cgtcattgag agatgtgcac catgagcctg tgtaccccca gccgcctttc
      1330       1340       1350       1360       1370       1380
agctactccg atctgtctcg agaggacaaa aagcaagtac agtttgtgtc cgagccctgc
      1390       1400       1410       1420       1430       1440
agcctctcca taaacggagt gatcttcggc ttgacatcca cagatctgct tttccacctg
      1450       1460       1470       1480       1490       1500
ggggccgagg agatcagtag ttcttccgga acttcagaca gattcagccg aatactcaag
      1510       1520       1530       1540       1550       1560
cacatcttga cccagaggag ctactaccca ctctacccgc cccaagaaga catggccatt
      1570       1580       1590       1600       1610       1620
gactatgagt cgttctatgt ttacgcacag ctgcctgtca ccccagatgt cctcatcatc
      1630       1640       1650       1660       1670       1680
ccgtcagagc tgaggtactt cgtgaaggat gtcctcggct gtgtctgtgt gaaccctggg
      1690       1700       1710       1720       1730       1740
cgccttacca aagggcaggt gggaggcacc ttcgcccgac tctaccttag gaggccggca
      1750       1760       1770       1780       1790
gcggacgggg cagagaggca gagcccatgc attgctgtgc aggtcgtcag gatctga

Last modification date: Oct. 2, 2011