Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Exodeoxyribonuclease 1


DESCRIPTION:
5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs.

STRUCTURE SIMILARITY:
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.


PROTEIN TYPE(S):
5'-3' exonuclease
DNase
RNase


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MGIKGLLGLL KPMQKSSHVE EFSGKTLGVD GYVWLHKAVF TCAHELAFNK ETDKYLKYAI
        70         80         90        100        110        120
HQALMLQYYG VKPLIVFDGG PLPCKASTEQ KRKERRQEAF ELGKKLWDEG KKSQAIMQFS
       130        140        150        160        170        180
RCVDVTPEMA WKLIIALREH GIESIVAPYE ADAQLVYLEK ENIIDGIITE DSDMLVFGAQ
       190        200        210        220        230        240
TVLFKMDGFG NCITIRRNDI ANAQDLNLRL PIEKLRHMAI FSGCDYTDGV AGMGLKTALR
       250        260        270        280        290        300
YLQKYPEPRA AIRAMRLDKS LKVPVSFEKE FALADLAFRH QRVYCPKDKT LVHLSPPERE
       310        320        330        340        350        360
LSVHEDAFIG SFFDNQLAID IAEGRSNPIT KCAFDIKDSS MQSFTKTTIT ISKRKGISKT
       370        380        390        400        410        420
DISNFFMKSI PPSKRPTKST SLIDVTNVKV QRTHLANDIS SEKQSIKSAN EKAYVTPKSN
       430        440        450        460        470        480
SLKPGFGKSL SDISNSATKN ENVPFLPPRT GVSKYFKLQK NTEKEIDEQV PSQSNNTTPT
       490        500        510        520        530        540
SAKSDSASPQ NWFSSFSYQT PNSASPPFSS LSHTLPISAL AKIGHDALNR KNHASLPSRR
       550        560        570
IVYKPPSSPS TPISMNPRPK GILSLQQYKF R  

Encoded by exo1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgggaatta aaggtctttt gggacttttg aagcctatgc agaaaagctc tcatgtcgag
        70         80         90        100        110        120
gagttttctg gcaagacttt gggagttgat ggatatgttt ggttgcacaa ggcagtgttt
       130        140        150        160        170        180
acatgtgctc atgaattagc atttaacaag gaaaccgata aatacctaaa gtatgctatt
       190        200        210        220        230        240
catcaggcgt taatgctaca atattatggt gtaaaacctt taatagtatt cgatggagga
       250        260        270        280        290        300
cctcttccct gtaaagcatc aactgagcaa aaaagaaaag aacgtcgcca agaggcattt
       310        320        330        340        350        360
gaacttggta agaaattgtg ggatgaaggt aagaaaagtc aagcaataat gcaattctca
       370        380        390        400        410        420
cgctgtgttg atgtgacccc agaaatggct tggaagttaa taatcgcttt gagagaacat
       430        440        450        460        470        480
gggattgaat caatcgttgc tccgtatgaa gcagatgctc aactcgtata tttggagaag
       490        500        510        520        530        540
gaaaatatca ttgatggcat tattacggaa gactctgata tgctagtttt tggcgctcaa
       550        560        570        580        590        600
acggtactat ttaagatgga tggatttggg aattgcataa ctattagacg taatgacata
       610        620        630        640        650        660
gcaaacgcac aagacttgaa tctccgtctt ccgattgaaa aacttcgaca tatggcaata
       670        680        690        700        710        720
ttttccggat gtgattacac agatggtgta gctggaatgg gattaaaaac tgctttacgt
       730        740        750        760        770        780
tatttgcaga aatatcctga acctcgggca gctattcgtg caatgagact tgataaaagc
       790        800        810        820        830        840
cttaaagttc cagtatcttt tgaaaaggag tttgcacttg ctgacctagc ctttcgacat
       850        860        870        880        890        900
caacgtgtat attgtccgaa agacaaaact ctagttcatc tgagtcctcc tgaaagggaa
       910        920        930        940        950        960
ctttctgtac atgaggatgc atttataggc tcattttttg ataatcagtt ggctattgat
       970        980        990       1000       1010       1020
atagcagagg gaagatctaa tccaattacg aaatgtgctt ttgatatcaa ggattcgtct
      1030       1040       1050       1060       1070       1080
atgcaatcat ttaccaaaac tacaattact attagtaaac gaaagggtat atcaaagacg
      1090       1100       1110       1120       1130       1140
gatatttcca acttttttat gaaatctatt cctccttcta aacgtcctac caaaagcacg
      1150       1160       1170       1180       1190       1200
agccttattg atgttaccaa cgtcaaagtg caacgaactc atttagcaaa tgatatttca
      1210       1220       1230       1240       1250       1260
tccgaaaaac aatcaatcaa atctgcgaat gaaaaagcat atgttactcc aaaatcaaat
      1270       1280       1290       1300       1310       1320
tctttaaaac caggttttgg aaaatcactt tccgatatct ctaattcagc gacaaagaat
      1330       1340       1350       1360       1370       1380
gaaaatgtcc ctttccttcc tccgagaaca ggtgttagta aatattttaa acttcaaaaa
      1390       1400       1410       1420       1430       1440
aatactgaaa aagaaattga tgagcaagta cctagtcaat ccaacaatac aactccaaca
      1450       1460       1470       1480       1490       1500
tctgctaaat cagattctgc ttcaccccaa aattggtttt cttcattctc ttaccaaaca
      1510       1520       1530       1540       1550       1560
ccgaattctg cttcaccccc gttttcttca ctatctcata cactcccaat ttcagcactt
      1570       1580       1590       1600       1610       1620
gctaaaattg gtcatgatgc gttaaaccgc aaaaatcatg cctctcttcc gtctcgtcgg
      1630       1640       1650       1660       1670       1680
attgtgtata agccaccgtc tagtccctca accccaatat ctatgaatcc tagacctaaa
      1690       1700       1710
ggaatcctat cacttcagca atataaattt cgttag  

Last modification date: Oct. 2, 2011