Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA mismatch repair protein msh2


DESCRIPTION:
Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA. Required for correct termination of copy synthesis during mating-type switching. Also required for proper chromosome organization during meiosis.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSSRNASIAN ERTDEARMFN FYEKMPKDTN TVRVFDRGEF YVAIGEDASF VAQNAYHTTS
        70         80         90        100        110        120
VLKHHNVSNT SYCNLSPSLF IKFAEDVLSN LAKRVEIWGA NSAKTGFELL KQASPGNMQM
       130        140        150        160        170        180
LEDLLVSENY QESTAISDSS VSSVLLAVTT RVKQDQRIIG VAFIDPILKK LGVSEFVDSD
       190        200        210        220        230        240
AYTNFEALIV QVGAKECIIS QSGHESTNGN SAVSINTAEI NRLRNIIEGC GALVTTIRSS
       250        260        270        280        290        300
EFSARDVELE LSKVLDSPVT HALVPELGLQ LAMASCNALL RYLGPALLNP DMEDDRENTS
       310        320        330        340        350        360
RKLHLYHHNL EQYMRLDIAA VRSLNLLPPP NGNAHKTMSL YGLLNHCRTA MGARNLRRWI
       370        380        390        400        410        420
VQPLLDAKSI ERRHDLVSAL VEDAEARQLL LDDDHLLRSI PDIPKLCRRL TRGSASLEDV
       430        440        450        460        470        480
VRIYQMAKAL PKIVTVLDSL TSEHKDLVDK VYTNVLNNHC KNLEKLIELV ETTIDLEALD
       490        500        510        520        530        540
SHQYIIRAEF DEELLDLRQR LDELQHSIFE EHKRVGSDLH QDTEKKLHLE QHHLYGWCLR
       550        560        570        580        590        600
LTRTEAGCLR GRSSHYTELS TQKNGVYFTT KRLHSLNNSY MDHQKSYRYH QNGLAREVIK
       610        620        630        640        650        660
IAATYGPPLE AIGQVIAHLD VILSFAHAST VAVIPYVRPN IVDSSIAQEK HGQSSNILDI
       670        680        690        700        710        720
VSLEDTPNFE EIRRTLENNH CARLYLKQAR HPCLEAQDDV KFIPNDVNLE HGSSELLIIT
       730        740        750        760        770        780
GPNMGGKSTY IRQVGVITVM AQIGCPVPCE VADLDIIDAI LARVGASDSQ LKGISTFMAE
       790        800        810        820        830        840
MLETATILRA ATPRSLIIID ELGRGTSTTD GFGLAWAITE HIVTQIGCFC LFATHYHEMT
       850        860        870        880        890        900
KLSEEITTVK NLHVTAYVGD SESKDVALLY NVCEGASDRS FGIHVAKLAH FPPKIIEMAS
       910        920        930        940        950        960
NKAAELEAED SGAQGDTQEV KSKKEGMAIV RDIMRQWRSN VKPEMTQQQM MDQFQKVIGS
       970        980
FAQQINSNNW LQSRVSTNEV SS   

Encoded by msh2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcttcta gaaacgcttc aattgctaat gaaagaactg atgaggcaag gatgtttaat
        70         80         90        100        110        120
ttttatgaaa aaatgcctaa agatacaaac acagtgcgtg tatttgatcg aggggaattt
       130        140        150        160        170        180
tacgttgcaa taggagaaga cgcttcgttt gttgctcaaa acgcgtatca cactacttcg
       190        200        210        220        230        240
gtgctaaaac accacaatgt gtctaataca tcttattgta acttatctcc ttcactattt
       250        260        270        280        290        300
attaagtttg cggaagatgt tttaagcaac cttgcaaaga gagttgaaat ttggggagcc
       310        320        330        340        350        360
aattccgcaa agacaggatt tgaattgttg aagcaagcta gtcctggaaa tatgcaaatg
       370        380        390        400        410        420
ctggaagatt tgcttgttag tgagaattat caagaatcca cagccattag tgatagctca
       430        440        450        460        470        480
gttagttcgg ttttgttggc tgttactact agggttaaac aagatcagcg aataattggc
       490        500        510        520        530        540
gttgctttta tagatccaat tttaaaaaaa ttaggtgttt cagaatttgt tgactcagat
       550        560        570        580        590        600
gcttatacga actttgaagc tctcatagtg caagttggag cgaaagagtg cataatatcg
       610        620        630        640        650        660
caatctgggc atgaatcgac gaatggcaat tcagccgttt ctattaacac ggcagaaatc
       670        680        690        700        710        720
aatcgtcttc gaaatattat tgaaggttgt ggcgcattag ttacaactat aagaagctct
       730        740        750        760        770        780
gaattttcgg ctcgagatgt tgaacttgag ctctcaaaag tgctcgacag tccagttaca
       790        800        810        820        830        840
catgctcttg ttccagaact aggtctacaa ttagcaatgg catcctgcaa tgcattgctt
       850        860        870        880        890        900
cgctatttag gacctgcgtt actaaaccct gacatggaag acgaccgtga aaacacatct
       910        920        930        940        950        960
cgaaagctcc atctgtatca tcacaacttg gaacaataca tgcgattaga tattgcagca
       970        980        990       1000       1010       1020
gttcgttctc ttaacctact tcctcctccc aatggtaatg ctcataaaac aatgagtctt
      1030       1040       1050       1060       1070       1080
tatggtttac ttaatcattg tagaactgcg atgggagcaa ggaatttaag aagatggatt
      1090       1100       1110       1120       1130       1140
gttcagccac ttttggatgc aaaatcaatt gaacgaagac atgacttggt ctccgcactt
      1150       1160       1170       1180       1190       1200
gtggaagatg ctgaggcacg ccagttattg cttgatgatg atcatcttct tcgttcaatt
      1210       1220       1230       1240       1250       1260
ccagatattc ctaaactatg caggcgttta actcgtggat cagctagtct agaagatgtt
      1270       1280       1290       1300       1310       1320
gtacgtattt atcaaatggc aaaggcactt ccgaagatcg ttacggtact tgactctttg
      1330       1340       1350       1360       1370       1380
actagtgaac ataaagattt ggtggataaa gtatacacga acgtccttaa caatcattgc
      1390       1400       1410       1420       1430       1440
aaaaacttgg aaaaattaat agagcttgtt gaaaccacca tcgacttgga agcattggat
      1450       1460       1470       1480       1490       1500
tcacatcagt atattatccg tgcagagttt gatgaggagc tattagattt gcgtcaacga
      1510       1520       1530       1540       1550       1560
ttagacgaat tacagcattc tatctttgaa gaacataaaa gggtcggttc agatctccac
      1570       1580       1590       1600       1610       1620
caagataccg agaaaaaatt acatcttgag caacatcacc tctatggatg gtgtctacgc
      1630       1640       1650       1660       1670       1680
cttactagaa cagaagctgg ctgtttaaga ggccgtagtt ctcattatac agaattatca
      1690       1700       1710       1720       1730       1740
actcaaaaaa atggagtcta ctttaccact aaacgtcttc attcactaaa caattcttat
      1750       1760       1770       1780       1790       1800
atggatcacc aaaaaagcta ccggtaccac caaaatgggc ttgcacgtga agttataaag
      1810       1820       1830       1840       1850       1860
atagctgcaa catacggtcc tcctttggag gcgattggcc aagtaattgc tcatttggac
      1870       1880       1890       1900       1910       1920
gtgattctaa gtttcgcaca tgcaagtacg gtagctgtaa taccttatgt aagaccaaat
      1930       1940       1950       1960       1970       1980
attgtggatt caagcattgc acaagaaaag catggacaaa gtagcaatat tttggacatt
      1990       2000       2010       2020       2030       2040
gtttcattag aagatactcc taattttgaa gaaatacgaa gaactctaga aaataatcat
      2050       2060       2070       2080       2090       2100
tgtgctcgtc tctacctaaa acaagcgcga catccttgtt tggaagctca ggacgatgtg
      2110       2120       2130       2140       2150       2160
aagttcatac ccaatgatgt taatcttgag catggaagtt cagagctatt aatcataacc
      2170       2180       2190       2200       2210       2220
ggaccaaata tgggtggaaa atcaacgtat atccgtcaag ttggagttat taccgtcatg
      2230       2240       2250       2260       2270       2280
gcacagattg gttgtccagt gccttgtgaa gtggctgatc tagatattat tgatgctatc
      2290       2300       2310       2320       2330       2340
cttgcacgtg tcggagccag cgactcacag cttaaaggca tttctacttt catggccgaa
      2350       2360       2370       2380       2390       2400
atgttggaga ccgctacgat tttgagagct gccacaccgc gatccttaat catcattgat
      2410       2420       2430       2440       2450       2460
gaattaggac gagggactag cacaaccgat ggttttggat tagcgtgggc tattacagaa
      2470       2480       2490       2500       2510       2520
cacatcgtga ctcaaatcgg ttgcttttgc cttttcgcaa cacattatca tgaaatgacc
      2530       2540       2550       2560       2570       2580
aaactatcag aagaaatcac tactgtcaaa aatttgcatg ttacagccta tgtaggtgat
      2590       2600       2610       2620       2630       2640
tcagaatcga aggatgtagc tttactctat aatgtttgtg aaggagctag tgatcggagt
      2650       2660       2670       2680       2690       2700
tttggaatcc atgttgctaa acttgcgcac ttccctccca agattattga aatggcaagc
      2710       2720       2730       2740       2750       2760
aacaaagccg cagaattaga agctgaagac tctggagccc aaggggatac tcaagaagtg
      2770       2780       2790       2800       2810       2820
aaatctaaaa aagaaggtat ggcaattgta cgtgatataa tgagacaatg gcgtagcaac
      2830       2840       2850       2860       2870       2880
gtcaaaccag aaatgactca gcaacaaatg atggaccaat ttcaaaaagt catcggctca
      2890       2900       2910       2920       2930       2940
ttcgcacagc aaatcaattc caacaactgg ctacaatcca gggtatccac aaatgaggtt

tcctcatga     

Last modification date: Oct. 2, 2011