Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA mismatch repair protein msh6


DESCRIPTION:
Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSVGNVGKQR EKTKDSSAKT KQKTLFGFFS KIPNVKQEKS DSTLSSSSNH DSNHDTPADV
        70         80         90        100        110        120
DNSSNVNKNS SSPERELPTS PSHHANTEID SSSSMLPPPS SDPFSSPLSS SLHRSSPKRP
       130        140        150        160        170        180
HDSLGEESPG KLLRTSVKQE PDSEEEIDSP TKKKSFKSLD TSIFQAEDQF RHPVSSKLEN
       190        200        210        220        230        240
SELSEVDKPF IASRRSRKPV SYAESDEDED FDDAPTKGSR HKRIVSDDES DDYVEPDHIS
       250        260        270        280        290        300
EASSEASLPI DEVESMDEDV DGYSDHSVSV AAPIPKKESR KESSNSLYES YRLGSQIASP
       310        320        330        340        350        360
SPSVSGSASP TKSNKNGVLN REEKRRQRME AFKKENNERY EWLLDVRDAD QNRVGDPNYD
       370        380        390        400        410        420
PRTLYIPPSA WATFKPFEKQ FWKIKKDLMD TVVFFQKGKF YELYENDAAI GHQVFSLKLT
       430        440        450        460        470        480
DRVNMKMVGI PEASFDYWAS QFIAKGYRIA RVDQLETALG KEIKDRQRTQ KEEKVVQRGL
       490        500        510        520        530        540
TQVLTSGTLV DEAMLTSDLS TYCMAIKESL QSDNEEPSFG ICFIDTSTGG FHMCEFTDDI
       550        560        570        580        590        600
HRTKLDTLLT QVRPKELILE KSKISQKSIR AIKYCVSSSS IWNFIKPYTE FWDNERVERE
       610        620        630        640        650        660
IIAGDYFKNG LEGAPKILKS YLSEKPLAIS AFGALFWYLR QLKLDKDMCS MGNFDEYDAS
       670        680        690        700        710        720
QQSTSLLMNG QTLKNLEIFS NSFDGGSEGT LFHLLCRCVT PFGKRLFHTW LCHPLRSGTA
       730        740        750        760        770        780
INARLDVVEL IADNPVIRDT IWGFLHKLPD LERLISRVHA GRSKPADFVR VLEGFQRINS
       790        800        810        820        830        840
AFDQLREEFM EVAEGTLLGE IIQSAPNMKE ELEAWTRAFN WQKASEEGVF EPEIGFEAEY
       850        860        870        880        890        900
DTSQKYQSEL KNELYALLEQ YKKQLRCSSL NFKNIGKEVY QVEVPSDVKV PVNWCKMSGT
       910        920        930        940        950        960
KKTNRYYNDE LRKKIKKLLE AEELHLAIMS RMQEKFYIRF DSNYEQWLAL IKYTASIDCF
       970        980        990       1000       1010       1020
FSLSQAAAAL GEPYCRPEII EQKDGHLYFE ELRHPCINAS AASTFVPNDV VLGGESPNMI
      1030       1040       1050       1060       1070       1080
VLTGPNMAGK STLLRQVCIA VIMAQLGCWV PAKRASITPM TSIYTRLGAN DDIMSARSTF
      1090       1100       1110       1120       1130       1140
MVELSETKKI LDECGPKSLV ILDELGRGTS TYDGHAIAYA VLHHLVSNIG CLGFFSTHYQ
      1150       1160       1170       1180       1190       1200
SLCVDFMHHR QVRLMQMAAA VDEKIRRVTF LYKLEDGICP KSYGMNVASM AGLPEKVIDA
      1210       1220       1230       1240       1250
AEEKASELEQ ASASFINASD DIALMSDFLQ VLRISKSIEP LTAVNIPLIL DSFE

Encoded by msh6 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgagcgttg ggaacgttgg caagcaaagg gagaaaacaa aagattcatc agctaaaaca
        70         80         90        100        110        120
aagcagaaaa ccctctttgg gtttttctcc aaaatcccga atgtgaaaca agagaagtcg
       130        140        150        160        170        180
gattctacat tatctagtag ttcgaatcac gactctaatc atgatacgcc tgctgatgtt
       190        200        210        220        230        240
gacaacagct ccaatgtgaa caaaaactct tcgtctccgg aacgcgaatt gccaacgagt
       250        260        270        280        290        300
ccttctcatc atgcgaatac cgagatagat tccagttcat ctatgcttcc tcctccatca
       310        320        330        340        350        360
agtgatccat tttcctcacc gctttctagc agcctacacc gatcatctcc taaacgccct
       370        380        390        400        410        420
catgattctt tgggcgagga gtcaccaggt aaattgcttc gcacgtctgt gaagcaagag
       430        440        450        460        470        480
cccgactctg aagaagaaat cgattctccg acgaaaaaga aaagttttaa aagtttggat
       490        500        510        520        530        540
acatcaatat ttcaagctga agatcaattt cgtcatcctg tctcgtcgaa gctggaaaat
       550        560        570        580        590        600
tcggaattat ctgaagtcga caagcctttt atagcttctc ggcgttcaag gaagcctgtt
       610        620        630        640        650        660
tcctacgctg aaagtgatga agacgaagac ttcgacgatg cacctaccaa aggatctcgt
       670        680        690        700        710        720
cataaaagaa tcgtttctga tgacgaatcg gatgactacg ttgagcccga tcatatttcg
       730        740        750        760        770        780
gaagcctcat ctgaggcatc cttgcctatt gatgaagtcg aatctatgga tgaggatgtt
       790        800        810        820        830        840
gatggatatt cagatcattc cgtttctgtg gctgctccaa ttcccaaaaa ggaatctcga
       850        860        870        880        890        900
aaggagagtt ccaattcttt gtatgaaagt tatcggctag gctctcaaat tgccagtcca
       910        920        930        940        950        960
agcccttcgg tctcgggttc tgcatctccc acaaaatcga ataaaaacgg tgtcctgaac
       970        980        990       1000       1010       1020
agagaagaaa aaagaaggca aagaatggag gcatttaaaa aagaaaacaa cgaacgttac
      1030       1040       1050       1060       1070       1080
gagtggttgc tagatgttcg agatgctgat caaaatcgag tgggtgatcc taattatgat
      1090       1100       1110       1120       1130       1140
ccgcgcacat tgtatatccc accttcagct tgggcaactt tcaagccatt tgagaaacaa
      1150       1160       1170       1180       1190       1200
ttttggaaaa ttaaaaagga ccttatggat acagttgttt tttttcagaa gggaaaattt
      1210       1220       1230       1240       1250       1260
tatgagttat atgagaatga tgccgctatc ggacatcagg tattttcctt aaagttaact
      1270       1280       1290       1300       1310       1320
gatagagtta atatgaagat ggttggaatt cctgaagcaa gttttgatta ctgggcatct
      1330       1340       1350       1360       1370       1380
caattcattg caaaggggta tcgtatagct cgagtcgacc aattggaaac cgctttaggt
      1390       1400       1410       1420       1430       1440
aaagaaataa aagatcgtca acgaactcag aaggaagaaa aagtagttca gcgaggcctt
      1450       1460       1470       1480       1490       1500
acccaagtct taacgagcgg gacccttgtt gacgaggcaa tgctgacttc tgacttgtca
      1510       1520       1530       1540       1550       1560
acatattgta tggctattaa agaaagtctt caatctgaca acgaagagcc ttcttttggt
      1570       1580       1590       1600       1610       1620
atctgcttca ttgatacctc gactggtggt tttcatatgt gtgaattcac tgatgatatc
      1630       1640       1650       1660       1670       1680
cacagaacta agcttgacac tttattaacg caagttcgcc ctaaggaact catccttgag
      1690       1700       1710       1720       1730       1740
aaatcaaaaa tttctcaaaa atcgattaga gcgataaaat actgtgtgtc ttcatcttca
      1750       1760       1770       1780       1790       1800
atctggaatt ttatcaagcc gtatacggaa ttttgggata acgaacgagt cgagagagaa
      1810       1820       1830       1840       1850       1860
attatagcag gagactattt caaaaatggt ttagaaggtg ctccaaagat actaaagtcg
      1870       1880       1890       1900       1910       1920
tatcttagtg aaaagcctct agccatcagt gcatttggtg ctttattttg gtatttacga
      1930       1940       1950       1960       1970       1980
caattaaagt tggataagga catgtgttcc atgggtaatt ttgacgaata tgacgcttct
      1990       2000       2010       2020       2030       2040
cagcagtcaa cttccctact tatgaatggg cagactttaa aaaatttaga aatattctct
      2050       2060       2070       2080       2090       2100
aactcttttg atggtggatc ggaaggcact ttgtttcatt tgctctgcag atgtgtcacc
      2110       2120       2130       2140       2150       2160
ccttttggta aacgtttatt tcatacatgg ctttgtcatc ctctaaggtc cggtactgca
      2170       2180       2190       2200       2210       2220
ataaatgcac gacttgatgt tgttgagtta atagccgaca accctgttat tcgagatacc
      2230       2240       2250       2260       2270       2280
atttgggggt ttctacataa acttcctgac ttggaacggt tgatatcacg ggtgcatgcc
      2290       2300       2310       2320       2330       2340
ggaagaagta aacccgcaga ttttgttcga gtattagaag gattccaacg aataaatagt
      2350       2360       2370       2380       2390       2400
gcatttgatc agcttcgcga ggaattcatg gaagtcgctg aaggaacttt actaggagag
      2410       2420       2430       2440       2450       2460
ataattcaaa gtgcacctaa catgaaagag gaattagaag catggacccg agctttcaat
      2470       2480       2490       2500       2510       2520
tggcaaaagg cttcagaaga aggtgttttc gaaccagaga ttggctttga agccgaatat
      2530       2540       2550       2560       2570       2580
gatacttctc aaaaatacca gtccgaactt aaaaacgaat tgtatgcgct tttagagcaa
      2590       2600       2610       2620       2630       2640
tacaagaagc agctaaggtg ctcgtctctt aattttaaaa atattggtaa agaggtttat
      2650       2660       2670       2680       2690       2700
caggtcgaag tcccaagcga tgttaaagta ccggttaatt ggtgcaaaat gtcaggtacc
      2710       2720       2730       2740       2750       2760
aaaaaaacca atcgatacta taatgatgaa ctacgaaaga aaataaagaa attactagag
      2770       2780       2790       2800       2810       2820
gcggaagagc ttcatttagc aattatgtcg cgaatgcagg agaaatttta tattcgattc
      2830       2840       2850       2860       2870       2880
gattctaatt atgagcaatg gttggcttta attaaatata ctgcatctat tgattgcttt
      2890       2900       2910       2920       2930       2940
ttcagcctta gtcaagcagc cgcagcgttg ggtgagccat attgtagacc ggaaattatt
      2950       2960       2970       2980       2990       3000
gaacagaagg acggacactt gtattttgag gagttgagac atccttgtat aaacgcaagt
      3010       3020       3030       3040       3050       3060
gcggcttcaa ctttcgttcc taatgatgtc gttttaggag gtgaatcccc aaacatgatt
      3070       3080       3090       3100       3110       3120
gttttgaccg gtccaaacat ggctggaaag tccacattat tgcgtcaagt ctgtattgct
      3130       3140       3150       3160       3170       3180
gttataatgg ctcaactagg gtgctgggtt ccggctaaac gtgctagtat aacacctatg
      3190       3200       3210       3220       3230       3240
accagcattt acactagatt aggtgccaat gatgatataa tgtcggcacg aagtactttt
      3250       3260       3270       3280       3290       3300
atggttgaac tttcggagac aaagaaaatt ttggacgaat gtggacctaa aagtttggta
      3310       3320       3330       3340       3350       3360
attttagatg aactaggtcg tggaactagt acttatgatg gtcacgcgat agcttacgct
      3370       3380       3390       3400       3410       3420
gtacttcatc atttggtttc taatattggg tgtttgggat ttttttctac acattatcaa
      3430       3440       3450       3460       3470       3480
agtctttgcg ttgattttat gcatcatcga caagtacgat tgatgcagat ggctgcagct
      3490       3500       3510       3520       3530       3540
gttgatgaaa aaatcagacg tgtaacgttt ttgtataagc tggaagatgg tatttgccct
      3550       3560       3570       3580       3590       3600
aagtcttacg gtatgaatgt tgctagtatg gccggcttac ctgagaaggt aattgatgcg
      3610       3620       3630       3640       3650       3660
gccgaagaga aggcctcgga acttgagcaa gcgtctgcca gcttcattaa cgcaagcgat
      3670       3680       3690       3700       3710       3720
gacattgctt taatgagtga tttccttcaa gtgttgcgca tatcaaagtc aattgaacct
      3730       3740       3750       3760
ttgacagcag tgaatatacc tctcatactt gattcgtttg aataa 

Last modification date: Oct. 2, 2011