Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Putative MutL protein homolog 1


DESCRIPTION:
This protein is involved in the repair of mismatches in DNA (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutL/hexB family.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MDVNSRAKIR PLDQLVINKI AAGEIIERPE NAIKELIENS LDAGSTSIDV LLKDGGLKLL
        70         80         90        100        110        120
QITDNGSGIQ YDDLPYLCQR FSTSKIDNFN DLQHLQTFGF RGEALASISH VAKVTVVTKL
       130        140        150        160        170        180
SSDIHAWKAF YVDGALAPIS PGMSPAPQPC AGKQGTVITA EDLFYNVRSR KSALKNGSEE
       190        200        210        220        230        240
FRRIMILVQK YAIHNDQVSF NCKKVGDTVA SLSLSSRLSK ADKIRHIYGP RVASHLRDFS
       250        260        270        280        290        300
LGEGQSSIVG FSANGFISNA DFQDKKSNLI LFINNRLVES VELRHALEET YAKYLHKGAS
       310        320        330        340        350        360
YFVYLSLNMS PEQLDVNVHP SKRIVHFLYD QEIATSICDK LGEILERTDT ERSYPLQAMI
       370        380        390        400        410        420
PSISNTKNAE SSSQKAVRTY ENYLVRTDPR ERSIKSMLSD NFLQRSSNNY DNEIIEKVDS
       430        440        450        460        470        480
ANSNKNATND IKDLQTEEIV EEGNSIDLES IKSLQKQVIN SMHVLATNIL TEHKYVGLVC
       490        500        510        520        530        540
PTRRIAAVQH NIGLYVVDYG KLSYHLFYQI CLTEFGNYGE FVLETPLSIS DLFEIVNGDE
       550        560        570        580        590        600
DKSESEKFTR LLVSRRDMLK DYFSISVTSG GLLTAVPMLS PKYHPPFEQL PLLISSLTPK
       610        620        630        640        650        660
FFDWLDEKSC LNGIMKAIAK FYVPLPLSYE ESDVKSIRSL ESCLEDYLFP EFRRRVICPK
       670        680
KVFEEKCIYQ ITSLPRLYNV FERC   

Encoded by mlh1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggatgtca attcacgagc aaaaattcgt cctttggatc aattggttat taacaaaata
        70         80         90        100        110        120
gccgcagggg agattataga aagacctgaa aatgctatta aagagttaat tgaaaattca
       130        140        150        160        170        180
cttgatgctg ggagtacaag cattgatgtt ttgctaaaag atggcggctt gaagcttctt
       190        200        210        220        230        240
caaattactg acaatggatc tggtatacag tatgatgatc ttccttattt atgccagagg
       250        260        270        280        290        300
tttagtacgt ctaaaattga taattttaat gatttacaac atttacaaac atttggattt
       310        320        330        340        350        360
cgtggagaag cacttgcgag tatcagtcat gtcgcgaaag ttacagtagt aacaaagctt
       370        380        390        400        410        420
tcttcggata tacacgcatg gaaggctttt tatgttgatg gagctcttgc gcccattagc
       430        440        450        460        470        480
cctggaatga gtcctgctcc ccaaccttgt gctgggaagc aagggactgt aataacggct
       490        500        510        520        530        540
gaagatttat tttacaatgt acgtagtcgc aaatcagctt taaaaaatgg gtcagaggaa
       550        560        570        580        590        600
tttcgtcgca taatgatctt ggttcaaaaa tatgcaattc ataatgacca agtttcattc
       610        620        630        640        650        660
aactgtaaga aggttggtga caccgttgcc tctttatctt taagctctag gctttccaaa
       670        680        690        700        710        720
gcggataaaa ttagacatat ttatggacca agagtggcta gtcatttgag agatttttct
       730        740        750        760        770        780
ttaggagaag gacaatcgtc tattgttgga ttttcggcca atggttttat tagcaatgca
       790        800        810        820        830        840
gactttcaag ataaaaaaag caatttaatt ttatttatta ataatcgatt agtggaatcg
       850        860        870        880        890        900
gttgaactgc gacacgctct tgaggagact tatgctaaat accttcataa aggagcatct
       910        920        930        940        950        960
tactttgttt acttatcgtt aaatatgagt cctgagcaat tggatgttaa tgtccatcct
       970        980        990       1000       1010       1020
tcgaagagga ttgttcattt tttgtatgac caagagattg caacttctat ctgtgataaa
      1030       1040       1050       1060       1070       1080
ctaggtgaaa ttttggaacg gacggacact gaaaggtcgt atcctttgca agcaatgatt
      1090       1100       1110       1120       1130       1140
cctagcatct ctaataccaa aaacgctgaa agctctagtc aaaaagcagt gcgaacctat
      1150       1160       1170       1180       1190       1200
gaaaattatt tggttcgtac agatccgcgt gaaagaagta ttaaaagtat gctttcagat
      1210       1220       1230       1240       1250       1260
aactttttgc agcgatcatc aaataattat gacaatgaaa taattgaaaa agttgattcg
      1270       1280       1290       1300       1310       1320
gccaactcga ataaaaatgc aacaaatgac ataaaagatc ttcaaactga agaaattgtt
      1330       1340       1350       1360       1370       1380
gaagaaggga attctattga tttggaaagc atcaagtctt tacaaaagca agttataaat
      1390       1400       1410       1420       1430       1440
tcaatgcatg tcctggcgac taatattctt acggagcata agtatgtagg tttagtttgt
      1450       1460       1470       1480       1490       1500
cctacaagaa gaattgcggc ggttcagcat aacataggtt tatatgtggt cgactacgga
      1510       1520       1530       1540       1550       1560
aagctttcat atcatctgtt ttatcagatt tgtctcactg aatttggaaa ttacggcgaa
      1570       1580       1590       1600       1610       1620
tttgtactcg aaacaccttt gtcaatttcc gatttatttg aaatagtcaa tggtgatgaa
      1630       1640       1650       1660       1670       1680
gacaaatctg aaagtgaaaa atttacacgt ttattagttt cccgacgaga tatgttaaag
      1690       1700       1710       1720       1730       1740
gactactttt ctataagtgt cacgtcaggt ggattattga cagctgtacc gatgttaagt
      1750       1760       1770       1780       1790       1800
cctaaatatc atccaccttt tgagcaactt cctttgttaa ttagtagttt gactcctaag
      1810       1820       1830       1840       1850       1860
ttttttgatt ggttagatga gaagtcatgt ttaaatggaa tcatgaaagc aattgcaaaa
      1870       1880       1890       1900       1910       1920
ttttatgtcc ctctccctct ttcttatgaa gaaagtgatg tgaagagcat cagatccttg
      1930       1940       1950       1960       1970       1980
gagtcatgct tagaagatta tttgtttcct gaatttcgcc gaagggtaat ttgcccaaaa
      1990       2000       2010       2020       2030       2040
aaagtatttg aagagaagtg catatatcag atcacgagtt taccgcggct ctataatgtt
      2050
ttcgaacgtt gttaa    

Last modification date: Oct. 2, 2011