Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA mismatch repair protein MLH3


DESCRIPTION:
Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by corection of frameshift intermediates.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutL/hexB family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSQHIRKLDS DVSERLKSQA CTVSLASAVR EIVQNSVDAH ATTIDVMIDL PNLSFAVYDD
        70         80         90        100        110        120
GIGLTRSDLN ILATQNYTSK IRKMNDLVTM KTYGYRGDAL YSISNVSNLF VCSKKKDYNS
       130        140        150        160        170        180
AWMRKFPSKS VMLSENTILP IDPFWKICPW SRTKSGTVVI VEDMLYNLPV RRRILKEEPP
       190        200        210        220        230        240
FKTFNTIKAD MLQILVMHPM ISLNVQYTDK LRINTEVLFR SKNITEGLTK HQQMSQVLRN
       250        260        270        280        290        300
VFGAIIPPDM LKKVSLKFNE YQIEGIISKM PVGLKDLQFI YINGRRYADS AFQGYVDSLF
       310        320        330        340        350        360
QAQDFGEKGM SLLKTKSVGK PYRSHPVFIL DVRCPQTIDD LLQDPAKKIV KPSHIRTIEP
       370        380        390        400        410        420
LIVKTIRSFL TFQGYLTPDK SDSSFEIVNC SQKTATLPDS RIQISKRNQV LNSKMKIARI
       430        440        450        460        470        480
NSYIGKPAVN GCRINNSTIN YEKIKNIRID GQKSRLRNKL SSRPYDSGFT EDYDSIGKTI
       490        500        510        520        530        540
TDFSISRSVL AKYEVINQVD KKFILIRCLD QSIHNCPLLV LVDQHACDER IRLEELFYSL
       550        560        570        580        590        600
LTEVVTGTFV ARDLKDCCIE VDRTEADLFK HYQSEFKKWG IGYETIEGTM ETSLLEIKTL
       610        620        630        640        650        660
PEMLTSKYNG DKDYLKMVLL QHAHDLKDFK KLPMDLSHFE NYTSVDKLYW WKYSSCVPTV
       670        680        690        700        710
FHEILNSKAC RSAVMFGDEL TRQECIILIS KLSRCHNPFE CAHGRPSMVP IAELK

Encoded by MLH3 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgagccagc atattaggaa attagattct gatgtttctg aaagacttaa atctcaggca
        70         80         90        100        110        120
tgcacggtat cgctagcatc agcggttaga gaaatagttc aaaattctgt agatgcacac
       130        140        150        160        170        180
gctaccacta tcgacgtcat gatcgacctc cctaatttga gctttgcagt ttacgatgat
       190        200        210        220        230        240
ggtattggtt tgactcgaag tgacctaaat atattggcca cacaaaatta tacttccaaa
       250        260        270        280        290        300
atacgaaaga tgaatgattt agtaacgatg aaaacctacg gttacagagg agacgcccta
       310        320        330        340        350        360
tatagcattt ctaatgtctc taatctgttt gtttgttcca agaaaaagga ttacaactct
       370        380        390        400        410        420
gcatggatga gaaaatttcc atccaaaagc gtcatgttga gtgagaatac catactccca
       430        440        450        460        470        480
atagatcctt tttggaaaat ttgtccttgg agccgaacaa agtctggtac tgttgttatt
       490        500        510        520        530        540
gttgaagata tgctgtataa tttacctgtc cggcgcagaa tactaaagga agaaccccct
       550        560        570        580        590        600
ttcaagactt ttaacacaat aaaggcagat atgctacaga tactggtaat gcacccgatg
       610        620        630        640        650        660
atttcactca acgtacaata tacagacaaa ctcagaatca atacagaagt tcttttccgc
       670        680        690        700        710        720
tcaaagaaca taactgaggg gttaacaaag caccagcaaa tgtctcaagt actgagaaat
       730        740        750        760        770        780
gtgtttgggg caataatacc accggatatg cttaagaaag tttccttgaa gtttaatgaa
       790        800        810        820        830        840
tatcagattg aagggatcat atcgaagatg cccgttggat tgaaggatct tcaatttata
       850        860        870        880        890        900
tatatcaatg gcagacgtta tgcggacagc gcctttcaag gatacgtcga ttctttattc
       910        920        930        940        950        960
caagcacaag atttcgggga gaaaggcatg agtttactca aaactaaaag cgtgggaaaa
       970        980        990       1000       1010       1020
ccgtatcgat cacatcccgt cttcatcctt gatgttcggt gcccccaaac tatcgatgac
      1030       1040       1050       1060       1070       1080
ctgttacaag atccagcaaa gaaaattgtt aagccttccc atatacgtac cattgaacca
      1090       1100       1110       1120       1130       1140
ttgatcgtta agaccattcg ctcctttctg acatttcaag gatacttaac gcctgataaa
      1150       1160       1170       1180       1190       1200
tcagattcat ctttcgaaat agtcaattgt tcacagaaga cggcaacatt gcctgatagt
      1210       1220       1230       1240       1250       1260
cgaatccaaa tcagtaaacg taatcaagta ttaaattcaa aaatgaagat tgcacgcatt
      1270       1280       1290       1300       1310       1320
aattcataca taggaaaacc cgctgtcaat ggatgtagaa taaacaatag tacaataaac
      1330       1340       1350       1360       1370       1380
tacgaaaaaa tcaagaatat aagaatcgac ggtcagaaat caaggttacg gaataaactc
      1390       1400       1410       1420       1430       1440
tcttccaggc cctacgatag tggttttaca gaagattatg acagtatagg aaaaaccata
      1450       1460       1470       1480       1490       1500
acagattttt caatatcaag atctgtcctg gcaaaatatg aagtgattaa tcaagtagat
      1510       1520       1530       1540       1550       1560
aaaaaattta ttctcatacg ttgtttagac caatctattc ataattgccc actattagtt
      1570       1580       1590       1600       1610       1620
ctagttgatc aacatgcttg cgatgagagg ataagactag aagagctatt ttatagcctg
      1630       1640       1650       1660       1670       1680
ttgacagaag ttgtaaccgg aacttttgtt gcacgagacc tcaaggattg ttgcattgaa
      1690       1700       1710       1720       1730       1740
gttgatcgta ctgaggctga cttatttaag cattatcaaa gtgaatttaa aaagtgggga
      1750       1760       1770       1780       1790       1800
attggctatg aaacaattga gggaacaatg gaaacctcac ttttggaaat taaaacactg
      1810       1820       1830       1840       1850       1860
cctgagatgt taacttccaa atataacggg gataaagact acttaaaaat ggtcttgctg
      1870       1880       1890       1900       1910       1920
caacatgctc atgacctgaa ggatttcaaa aaacttccaa tggatttatc ccatttcgaa
      1930       1940       1950       1960       1970       1980
aactacactt cggttgataa attatattgg tggaagtact caagctgcgt tccaacggtc
      1990       2000       2010       2020       2030       2040
tttcatgaaa ttcttaacag caaggcatgc agatctgctg ttatgtttgg agatgaatta
      2050       2060       2070       2080       2090       2100
acccggcaag agtgcataat tttaattagc aagctctcgc gatgccataa cccattcgaa
      2110       2120       2130       2140
tgcgcccacg ggagaccttc tatggtaccc attgcagaat tgaagtaa 

Last modification date: Oct. 2, 2011