Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA mismatch repair protein MLH1


DESCRIPTION:
Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of different MutL heterodimers that form a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats, the repair of heteroduplex sites present in meiotic recombination intermediates, and the promotion of meiotic crossing-over.

MISCELLANEOUS:
Present with 319 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutL/hexB family.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSLRIKALDA SVVNKIAAGE IIISPVNALK EMMENSIDAN ATMIDILVKE GGIKVLQITD
        70         80         90        100        110        120
NGSGINKADL PILCERFTTS KLQKFEDLSQ IQTYGFRGEA LASISHVARV TVTTKVKEDR
       130        140        150        160        170        180
CAWRVSYAEG KMLESPKPVA GKDGTTILVE DLFFNIPSRL RALRSHNDEY SKILDVVGRY
       190        200        210        220        230        240
AIHSKDIGFS CKKFGDSNYS LSVKPSYTVQ DRIRTVFNKS VASNLITFHI SKVEDLNLES
       250        260        270        280        290        300
VDGKVCNLNF ISKKSISPIF FINNRLVTCD LLRRALNSVY SNYLPKGNRP FIYLGIVIDP
       310        320        330        340        350        360
AAVDVNVHPT KREVRFLSQD EIIEKIANQL HAELSAIDTS RTFKASSIST NKPESLIPFN
       370        380        390        400        410        420
DTIESDRNRK SLRQAQVVEN SYTTANSQLR KAKRQENKLV RIDASQAKIT SFLSSSQQFN
       430        440        450        460        470        480
FEGSSTKRQL SEPKVTNVSH SQEAEKLTLN ESEQPRDANT INDNDLKDQP KKKQKLGDYK
       490        500        510        520        530        540
VPSIADDEKN ALPISKDGYI RVPKERVNVN LTSIKKLREK VDDSIHRELT DIFANLNYVG
       550        560        570        580        590        600
VVDEERRLAA IQHDLKLFLI DYGSVCYELF YQIGLTDFAN FGKINLQSTN VSDDIVLYNL
       610        620        630        640        650        660
LSEFDELNDD ASKEKIISKI WDMSSMLNEY YSIELVNDGL DNDLKSVKLK SLPLLLKGYI
       670        680        690        700        710        720
PSLVKLPFFI YRLGKEVDWE DEQECLDGIL REIALLYIPD MVPKVDTSDA SLSEDEKAQF
       730        740        750        760
INRKEHISSL LEHVLFPCIK RRFLAPRHIL KDVVEIANLP DLYKVFERC 

Encoded by MLH1 gene


OTHER NAME(S):
PMS2


Nucleic acid sequence

        10         20         30         40         50         60
atgtctctca gaataaaagc acttgatgca tcagtggtta acaaaattgc tgcaggtgag
        70         80         90        100        110        120
atcataatat cccccgtaaa tgctctcaaa gaaatgatgg agaattccat cgatgcgaat
       130        140        150        160        170        180
gctacaatga ttgatattct agtcaaggaa ggaggaatta aggtacttca aataacagat
       190        200        210        220        230        240
aacggatctg gaattaataa agcagacctg ccaatcttat gtgagcgatt cacgacgtcc
       250        260        270        280        290        300
aaattacaaa aattcgaaga tttgagtcag attcaaacgt atggattccg aggagaagct
       310        320        330        340        350        360
ttagccagta tctcacatgt ggcaagagtc acagtaacga caaaagttaa agaagacaga
       370        380        390        400        410        420
tgtgcatgga gagtttcata tgcagaaggt aagatgttgg aaagccccaa acctgttgct
       430        440        450        460        470        480
ggaaaagacg gtaccacgat cctagttgaa gacctttttt tcaatattcc ttctagatta
       490        500        510        520        530        540
agggccttga ggtcccataa tgatgaatac tctaaaatat tagatgttgt cgggcgatac
       550        560        570        580        590        600
gccattcatt ccaaggacat tggcttttct tgtaaaaagt tcggagactc taattattct
       610        620        630        640        650        660
ttatcagtta aaccttcata taccgtccag gataggatta ggactgtgtt caataaatct
       670        680        690        700        710        720
gtggcttcga atttaattac ttttcatatc agcaaagtag aagatttaaa cctggaaagc
       730        740        750        760        770        780
gttgatggaa aggtgtgtaa tttgaatttc atatccaaaa agtccatttc accaattttt
       790        800        810        820        830        840
ttcattaata atagactagt gacatgtgat cttctaagaa gagctttgaa cagcgtttac
       850        860        870        880        890        900
tccaattatc tgccaaaggg caacagacct tttatttatt tgggaattgt tatagatccg
       910        920        930        940        950        960
gcggctgttg atgttaacgt tcacccgaca aagagagagg ttcgtttcct gagccaagat
       970        980        990       1000       1010       1020
gagatcatag agaaaatcgc caatcaattg cacgccgaat tatctgccat tgatacttca
      1030       1040       1050       1060       1070       1080
cgtactttca aggcttcttc aatttcaaca aacaagccag agtcattgat accatttaat
      1090       1100       1110       1120       1130       1140
gacaccatag aaagtgatag gaataggaag agtctccgac aagcccaagt ggtagagaat
      1150       1160       1170       1180       1190       1200
tcatatacga cagccaatag tcaactaagg aaagcgaaaa gacaagagaa taaactagtc
      1210       1220       1230       1240       1250       1260
agaatagatg cttcacaagc taaaattacg tcatttttat cctcaagtca acagttcaac
      1270       1280       1290       1300       1310       1320
tttgaaggat cgtctacaaa gcgacaactg agtgaaccca aggtaacaaa tgtaagccac
      1330       1340       1350       1360       1370       1380
tcccaagagg cagaaaagct gacactaaat gaaagcgaac aaccgcgtga tgccaataca
      1390       1400       1410       1420       1430       1440
atcaatgata atgacttgaa ggatcaacct aagaagaaac aaaagttggg ggattataaa
      1450       1460       1470       1480       1490       1500
gttccaagca ttgccgatga cgaaaagaat gcactcccga tttcaaaaga cgggtatatt
      1510       1520       1530       1540       1550       1560
agagtaccta aggagcgagt taatgttaat cttacgagta tcaagaaatt gcgtgaaaaa
      1570       1580       1590       1600       1610       1620
gtagatgatt cgatacatcg agaactaaca gacatttttg caaatttgaa ttacgttggg
      1630       1640       1650       1660       1670       1680
gttgtagatg aggaaagaag attagccgct attcagcatg acttaaagct ttttttaata
      1690       1700       1710       1720       1730       1740
gattacggat ctgtgtgcta tgagctattc tatcagattg gtttgacaga cttcgcaaac
      1750       1760       1770       1780       1790       1800
tttggtaaga taaacctaca gagtacaaat gtgtcagatg atatagtttt gtataatctc
      1810       1820       1830       1840       1850       1860
ctatcagaat ttgacgagtt aaatgacgat gcttccaaag aaaaaataat tagtaaaata
      1870       1880       1890       1900       1910       1920
tgggacatga gcagtatgct aaatgagtac tattccatag aattggtgaa tgatggtcta
      1930       1940       1950       1960       1970       1980
gataatgact taaagtctgt gaagctaaaa tctctaccac tacttttaaa aggctacatt
      1990       2000       2010       2020       2030       2040
ccatctctgg tcaagttacc attttttata tatcgcctgg gtaaagaagt tgattgggag
      2050       2060       2070       2080       2090       2100
gatgaacaag agtgtctaga tggtatttta agagagattg cattactcta tatacctgat
      2110       2120       2130       2140       2150       2160
atggttccga aagtcgatac atctgatgca tcgttgtcag aagacgaaaa agcccagttt
      2170       2180       2190       2200       2210       2220
ataaatagaa aggaacacat atcctcatta ctagaacacg ttctcttccc ttgtatcaaa
      2230       2240       2250       2260       2270       2280
cgaaggttcc tggcccctag acacattctc aaggatgtcg tggaaatagc caaccttcca
      2290       2300       2310
gatctataca aagtttttga gaggtgttaa   

Last modification date: Oct. 2, 2011