Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Exodeoxyribonuclease I


DESCRIPTION:
Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase.

CATALYTIC ACTIVITY:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MMNDGKQQST FLFHDYETFG THPALDRPAQ FAAIRTDSEF NVIGEPEVFY CKPADDYLPQ
        70         80         90        100        110        120
PGAVLITGIT PQEARAKGEN EAAFAARIHS LFTVPKTCIL GYNNVRFDDE VTRNIFYRNF
       130        140        150        160        170        180
YDPYAWSWQH DNSRWDLLDV MRACYALRPE GINWPENDDG LPSFRLEHLT KANGIEHSNA
       190        200        210        220        230        240
HDAMADVYAT IAMAKLVKTR QPRLFDYLFT HRNKHKLMAL IDVPQMKPLV HVSGMFGAWR
       250        260        270        280        290        300
GNTSWVAPLA WHPENRNAVI MVDLAGDISP LLELDSDTLR ERLYTAKTDL GDNAAVPVKL
       310        320        330        340        350        360
VHINKCPVLA QANTLRPEDA DRLGINRQHC LDNLKILREN PQVREKVVAI FAEAEPFTPS
       370        380        390        400        410        420
DNVDAQLYNG FFSDADRAAM KIVLETEPRN LPALDITFVD KRIEKLLFNY RARNFPGTLD
       430        440        450        460        470
YAEQQRWLEH RRQVFTPEFL QGYADELQML VQQYADDKEK VALLKALWQY AEEIV

Encoded by sbcB gene


OTHER NAME(S):
cpeA
ECK2005
JW1993
xonA


DESCRIPTION:
The C-terminus of Ssb binds and stimulates Exonuclease I activity (Lu, 2008). [More information is available at EcoGene: EG10926]. Exonuclease I (ExoI) hydrolyzes DNA through its 3'-5' exonuclease acitivity. [More information is available at EcoCyc: EG10926].


Nucleic acid sequence

        10         20         30         40         50         60
atgatgaatg acggtaagca acaatctacc tttttgtttc acgattacga aacctttggc
        70         80         90        100        110        120
acgcaccccg cgttagatcg ccctgcacag ttcgcagcca ttcgcaccga tagcgaattc
       130        140        150        160        170        180
aatgtcatcg gcgaacccga agtcttttac tgcaagcccg ctgatgacta tttaccccag
       190        200        210        220        230        240
ccaggagccg tattaattac cggtattacc ccgcaggaag cacgggcgaa aggagaaaac
       250        260        270        280        290        300
gaagccgcgt ttgccgcccg tattcactcg ctttttaccg taccgaagac ctgtattctg
       310        320        330        340        350        360
ggctacaaca atgtgcgttt cgacgacgaa gtcacacgca acatttttta tcgtaatttc
       370        380        390        400        410        420
tacgatcctt acgcctggag ctggcagcat gataactcgc gctgggattt actggatgtt
       430        440        450        460        470        480
atgcgtgcct gttatgccct gcgcccggaa ggaataaact ggcctgaaaa tgatgacggt
       490        500        510        520        530        540
ctaccgagct ttcgccttga gcatttaacc aaagcgaatg gtattgaaca tagcaacgcc
       550        560        570        580        590        600
cacgatgcga tggctgatgt gtacgccact attgcgatgg caaagctggt aaaaacgcgt
       610        620        630        640        650        660
cagccacgcc tgtttgatta tctctttacc catcgtaata aacacaaact gatggcgttg
       670        680        690        700        710        720
attgatgttc cgcagatgaa acccctggtg cacgtttccg gaatgtttgg agcatggcgc
       730        740        750        760        770        780
ggcaatacca gctgggtggc accgctggcg tggcatcctg aaaatcgcaa tgccgtaatt
       790        800        810        820        830        840
atggtggatt tggcaggaga catttcgcca ttactggaac tggatagcga cacattgcgc
       850        860        870        880        890        900
gagcgtttat ataccgcaaa aaccgatctt ggcgataacg ccgccgttcc ggttaagctg
       910        920        930        940        950        960
gtgcatatca ataaatgtcc ggtgctggcc caggcgaata cgctacgccc ggaagatgcc
       970        980        990       1000       1010       1020
gaccgactgg gaattaatcg tcagcattgc ctcgataacc tgaaaattct gcgtgaaaat
      1030       1040       1050       1060       1070       1080
ccgcaagtgc gcgaaaaagt ggtggcgata ttcgcggaag ccgaaccgtt tacgccttca
      1090       1100       1110       1120       1130       1140
gataacgtgg atgcacagct ttataacggc tttttcagtg acgcagatcg tgcagcaatg
      1150       1160       1170       1180       1190       1200
aaaattgtgc tggaaaccga gccgcgtaat ttaccggcac tggatatcac ttttgttgat
      1210       1220       1230       1240       1250       1260
aaacggattg aaaagctgtt gttcaattat cgggcacgca acttcccggg gacgctggat
      1270       1280       1290       1300       1310       1320
tatgccgagc agcaacgctg gctggagcac cgtcgccagg tcttcacgcc agagtttttg
      1330       1340       1350       1360       1370       1380
cagggttatg ctgatgaatt gcagatgctg gtacaacaat atgccgatga caaagagaaa
      1390       1400       1410       1420
gtggcgctgt taaaagcact ttggcagtac gcggaagaga ttgtctaa 

Last modification date: Oct. 2, 2011