Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA mismatch repair protein mutL


DESCRIPTION:
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of the final effector complex. The ATPase activity of mutL is stimulated by DNA.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutL/hexB family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
        70         80         90        100        110        120
CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA
       130        140        150        160        170        180
WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL
       190        200        210        220        230        240
ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV
       250        260        270        280        290        300
ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
       310        320        330        340        350        360
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR
       370        380        390        400        410        420
NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA
       430        440        450        460        470        480
PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC
       490        500        510        520        530        540
AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP
       550        560        570        580        590        600
ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL
       610
QSVDLHPAIK ALKDE    

Encoded by mutL gene


OTHER NAME(S):
ECK4166
JW4128


DESCRIPTION:
MutL DNA-binding is required for methyl-directed mismatch repair (Robertson, 2006). [More information is available at EcoGene: EG11281]. MutL is one of the components of the MutHLS complex. [More information is available at EcoCyc: EG11281].


Nucleic acid sequence

        10         20         30         40         50         60
atgccaattc aggtcttacc gccacaactg gcgaaccaga ttgccgcagg tgaggtggtc
        70         80         90        100        110        120
gagcgacctg cgtcggtagt caaagaacta gtggaaaaca gcctcgatgc aggtgcgacg
       130        140        150        160        170        180
cgtatcgata ttgatatcga acgcggtggg gcgaaactta tccgcattcg tgataacggc
       190        200        210        220        230        240
tgcggtatca aaaaagatga gctggcgctg gcgctggctc gtcatgccac cagtaaaatc
       250        260        270        280        290        300
gcctctctgg acgatctcga agccattatc agcctgggct ttcgcggtga ggcgctggcg
       310        320        330        340        350        360
agtatcagtt cggtttcccg cctgacgctc acttcacgca ccgcagaaca gcaggaagcc
       370        380        390        400        410        420
tggcaggcct atgccgaagg gcgcgatatg aacgtgacgg taaaaccggc ggcgcatcct
       430        440        450        460        470        480
gtggggacga cgctggaggt gctggatctg ttctacaaca ccccggcgcg gcgcaaattc
       490        500        510        520        530        540
ctgcgcaccg agaaaaccga atttaaccac attgatgaga tcatccgccg cattgcgctg
       550        560        570        580        590        600
gcgcgtttcg acgtcacgat caacctgtcg cataacggta aaattgtgcg tcagtaccgc
       610        620        630        640        650        660
gcagtgccgg aaggcgggca aaaagaacgg cgcttaggcg cgatttgcgg caccgctttt
       670        680        690        700        710        720
cttgaacaag cgctggcgat tgaatggcaa cacggcgatc tcacgctacg cggctgggtg
       730        740        750        760        770        780
gccgatccaa atcacaccac gcccgcactg gcagaaattc agtattgcta cgtgaacggt
       790        800        810        820        830        840
cgcatgatgc gcgatcgcct gatcaatcac gcgatccgcc aggcctgcga agacaaactg
       850        860        870        880        890        900
ggggccgatc agcaaccggc atttgtgttg tatctggaga tcgacccaca tcaggtggac
       910        920        930        940        950        960
gtcaacgtgc accccgccaa acacgaagtg cgtttccatc agtcgcgtct ggtgcatgat
       970        980        990       1000       1010       1020
tttatctatc agggcgtgct gagcgtgcta caacagcaac tggaaacgcc gctaccgctg
      1030       1040       1050       1060       1070       1080
gacgatgaac cccaacctgc accgcgttcc attccggaaa accgcgtggc ggcggggcgc
      1090       1100       1110       1120       1130       1140
aatcactttg cagaaccggc agctcgtgag ccggtagctc cgcgctacac tcctgcgcca
      1150       1160       1170       1180       1190       1200
gcatcaggca gtcgtccggc tgccccctgg ccgaatgcgc agccaggcta ccagaaacag
      1210       1220       1230       1240       1250       1260
caaggtgaag tgtatcgcca gcttttgcaa acgcccgcgc cgatgcaaaa attaaaagcg
      1270       1280       1290       1300       1310       1320
ccggaaccgc aggaacctgc acttgcggcg aacagtcaga gttttggtcg ggtactgact
      1330       1340       1350       1360       1370       1380
atcgtccatt ccgactgtgc gttgctggag cgcgacggca acatttcact tttatccttg
      1390       1400       1410       1420       1430       1440
ccagtggcag aacgttggct gcgtcaggca caattgacgc cgggtgaagc gcccgtttgc
      1450       1460       1470       1480       1490       1500
gcccagccgc tgctgattcc gttgcggcta aaagtttctg ccgaagaaaa atcggcatta
      1510       1520       1530       1540       1550       1560
gaaaaagcgc agtctgccct ggcggaattg ggtattgatt tccagtcaga tgcacagcat
      1570       1580       1590       1600       1610       1620
gtgaccatca gggcagtgcc tttaccctta cgccaacaaa atttacaaat cttgattcct
      1630       1640       1650       1660       1670       1680
gaactgatag gctacctggc gaagcagtcc gtattcgaac ctggcaatat tgcgcagtgg
      1690       1700       1710       1720       1730       1740
attgcacgaa atctgatgag cgaacatgcg cagtggtcaa tggcacaggc cataaccctg
      1750       1760       1770       1780       1790       1800
ctggcggacg tggaacggtt atgtccgcaa cttgtgaaaa cgccgccggg tggtctgtta
      1810       1820       1830       1840
caatctgttg atttacatcc ggcgataaaa gccctgaaag atgagtga 

Last modification date: Oct. 2, 2011