Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA mismatch repair protein mutS


DESCRIPTION:
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
        70         80         90        100        110        120
SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS
       130        140        150        160        170        180
DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY
       190        200        210        220        230        240
AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL
       250        260        270        280        290        300
LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT
       310        320        330        340        350        360
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA
       370        380        390        400        410        420
RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR
       430        440        450        460        470        480
DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG
       490        500        510        520        530        540
QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE
       550        560        570        580        590        600
ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP
       610        620        630        640        650        660
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA
       670        680        690        700        710        720
DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK
       730        740        750        760        770        780
ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG
       790        800        810        820        830        840
VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR
       850
QALEWIYRLK SLV    

Encoded by mutS gene


OTHER NAME(S):
ant
ECK2728
fdv
JW2703
plm


DESCRIPTION:
MutS has weak ATPase activity and may be involved in recognizing the DNA mismatch. [More information is available at EcoGene: EG10625]. MutS is one of the components of the MutHLS complex. [More information is available at EcoCyc: EG10625].


Nucleic acid sequence

        10         20         30         40         50         60
atgagtgcaa tagaaaattt cgacgcccat acgcccatga tgcagcagta tctcaggctg
        70         80         90        100        110        120
aaagcccagc atcccgagat cctgctgttt taccggatgg gtgattttta tgaactgttt
       130        140        150        160        170        180
tatgacgacg caaaacgcgc gtcgcaactg ctggatattt cactgaccaa acgcggtgct
       190        200        210        220        230        240
tcggcgggag agccgatccc gatggcgggg attccctacc atgcggtgga aaactatctc
       250        260        270        280        290        300
gccaaactgg tgaatcaggg agagtccgtt gccatctgcg aacaaattgg cgatccggcg
       310        320        330        340        350        360
accagcaaag gtccggttga gcgcaaagtt gtgcgtatcg ttacgccagg caccatcagc
       370        380        390        400        410        420
gatgaagccc tgttgcagga gcgtcaggac aacctgctgg cggctatctg gcaggacagc
       430        440        450        460        470        480
aaaggtttcg gctacgcgac gctggatatc agttccgggc gttttcgcct gagcgaaccg
       490        500        510        520        530        540
gctgaccgcg aaacgatggc ggcagaactg caacgcacta atcctgcgga actgctgtat
       550        560        570        580        590        600
gcagaagatt ttgctgaaat gtcgttaatt gaaggccgtc gcggcctgcg ccgtcgcccg
       610        620        630        640        650        660
ctgtgggagt ttgaaatcga caccgcgcgc cagcagttga atctgcaatt tgggacccgc
       670        680        690        700        710        720
gatctggtcg gttttggcgt cgagaacgcg ccgcgcggac tttgtgctgc cggttgtctg
       730        740        750        760        770        780
ttgcagtatg cgaaagatac ccaacgtacg actctgccgc atattcgttc catcaccatg
       790        800        810        820        830        840
gaacgtgagc aggacagcat cattatggat gccgcgacgc gtcgtaatct ggaaatcacc
       850        860        870        880        890        900
cagaacctgg cgggtggtgc ggaaaatacg ctggcttctg tgctcgactg caccgtcacg
       910        920        930        940        950        960
ccgatgggca gccgtatgct gaaacgctgg ctgcatatgc cagtgcgcga tacccgcgtg
       970        980        990       1000       1010       1020
ttgcttgagc gccagcaaac tattggcgca ttgcaggatt tcaccgccgg gctacagccg
      1030       1040       1050       1060       1070       1080
gtactgcgtc aggtcggcga cctggaacgt attctggcac gtctggcttt acgaactgct
      1090       1100       1110       1120       1130       1140
cgcccacgcg atctggcccg tatgcgccac gctttccagc aactgccgga gctgcgtgcg
      1150       1160       1170       1180       1190       1200
cagttagaaa ctgtcgatag tgcaccggta caggcgctac gtgagaagat gggcgagttt
      1210       1220       1230       1240       1250       1260
gccgagctgc gcgatctgct ggagcgagca atcatcgaca caccgccggt gctggtacgc
      1270       1280       1290       1300       1310       1320
gacggtggtg ttatcgcatc gggctataac gaagagctgg atgagtggcg cgcgctggct
      1330       1340       1350       1360       1370       1380
gacggcgcga ccgattatct ggagcgtctg gaagtccgcg agcgtgaacg taccggcctg
      1390       1400       1410       1420       1430       1440
gacacgctga aagttggctt taatgcggtg cacggctact acattcaaat cagccgtggg
      1450       1460       1470       1480       1490       1500
caaagccatc tggcacccat caactacatg cgtcgccaga cgctgaaaaa cgccgagcgc
      1510       1520       1530       1540       1550       1560
tacatcattc cagagctaaa agagtacgaa gataaagttc tcacctcaaa aggcaaagca
      1570       1580       1590       1600       1610       1620
ctggcactgg aaaaacagct ttatgaagag ctgttcgacc tgctgttgcc gcatctggaa
      1630       1640       1650       1660       1670       1680
gcgttgcaac agagcgcgag cgcgctggcg gaactcgacg tgctggttaa cctggcggaa
      1690       1700       1710       1720       1730       1740
cgggcctata ccctgaacta cacctgcccg accttcattg ataaaccggg cattcgcatt
      1750       1760       1770       1780       1790       1800
accgaaggtc gccatccggt agttgaacaa gtactgaatg agccatttat cgccaacccg
      1810       1820       1830       1840       1850       1860
ctgaatctgt cgccgcagcg ccgcatgttg atcatcaccg gtccgaacat gggcggtaaa
      1870       1880       1890       1900       1910       1920
agtacctata tgcgccagac cgcactgatt gcgctgatgg cctacatcgg cagctatgta
      1930       1940       1950       1960       1970       1980
ccggcacaaa aagtcgagat tggacctatc gatcgcatct ttacccgcgt aggcgcggca
      1990       2000       2010       2020       2030       2040
gatgacctgg cgtccgggcg ctcaaccttt atggtggaga tgactgaaac cgccaatatt
      2050       2060       2070       2080       2090       2100
ttacataacg ccaccgaata cagtctggtg ttaatggatg agatcgggcg tggaacgtcc
      2110       2120       2130       2140       2150       2160
acctacgatg gtctgtcgct ggcgtgggcg tgcgcggaaa atctggcgaa taagattaag
      2170       2180       2190       2200       2210       2220
gcattgacgt tatttgctac ccactatttc gagctgaccc agttaccgga gaaaatggaa
      2230       2240       2250       2260       2270       2280
ggcgtcgcta acgtgcatct cgatgcactg gagcacggcg acaccattgc ctttatgcac
      2290       2300       2310       2320       2330       2340
agcgtgcagg atggcgcggc gagcaaaagc tacggcctgg cggttgcagc tctggcaggc
      2350       2360       2370       2380       2390       2400
gtgccaaaag aggttattaa gcgcgcacgg caaaagctgc gtgagctgga aagcatttcg
      2410       2420       2430       2440       2450       2460
ccgaacgccg ccgctacgca agtggatggt acgcaaatgt ctttgctgtc agtaccagaa
      2470       2480       2490       2500       2510       2520
gaaacttcgc ctgcggtcga agctctggaa aatcttgatc cggattcact caccccgcgt
      2530       2540       2550       2560
caggcgctgg agtggattta tcgcttgaag agcctggtgt aa 

Last modification date: Oct. 2, 2011