Homo sapiens L. (human) [HSA]

Amino acids sequence

        10         20         30         40         50         60
MIKCLSVEVQ AKLRSGLAIS SLGQCVEELA LNSIDAEAKC VAVRVNMETF QVQVIDNGFG
        70         80         90        100        110        120
MGSDDVEKVG NRYFTSKCHS VQDLENPRFY GFRGEALANI ADMASAVEIS SKKNRTMKTF
       130        140        150        160        170        180
VKLFQSGKAL KACEADVTRA SAGTTVTVYN LFYQLPVRRK CMDPRLEFEK VRQRIEALSL
       190        200        210        220        230        240
MHPSISFSLR NDVSGSMVLQ LPKTKDVCSR FCQIYGLGKS QKLREISFKY KEFELSGYIS
       250        260        270        280        290        300
SEAHYNKNMQ FLFVNKRLVL RTKLHKLIDF LLRKESIICK PKNGPTSRQM NSSLRHRSTP
       310        320        330        340        350        360
ELYGIYVINV QCQFCEYDVC MEPAKTLIEF QNWDTLLFCI QEGVKMFLKQ EKLFVELSGE
       370        380        390        400        410        420
DIKEFSEDNG FSLFDATLQK RVTSDERSNF QEACNNILDS YEMFNLQSKA VKRKTTAENV
       430        440        450        460        470        480
NTQSSRDSEA TRKNTNDAFL YIYESGGPGH SKMTEPSLQN KDSSCSESKM LEQETIVASE
       490        500        510        520        530        540
AGENEKHKKS FLEHSSLENP CGTSLEMFLS PFQTPCHFEE SGQDLEIWKE STTVNGMAAN
       550        560        570        580        590        600
ILKNNRIQNQ PKRFKDATEV GCQPLPFATT LWGVHSAQTE KEKKKESSNC GRRNVFSYGR
       610        620        630        640        650        660
VKLCSTGFIT HVVQNEKTKS TETEHSFKNY VRPGPTRAQE TFGNRTRHSV ETPDIKDLAS
       670        680        690        700        710        720
TLSKESGQLP NKKNCRTNIS YGLENEPTAT YTMFSAFQEG SKKSQTDCIL SDTSPSFPWY
       730        740        750        760        770        780
RHVSNDSRKT DKLIGFSKPI VRKKLSLSSQ LGSLEKFKRQ YGKVENPLDT EVEESNGVTT
       790        800        810        820        830        840
NLSLQVEPDI LLKDKNRLEN SDVCKITTME HSDSDSSCQP ASHILNSEKF PFSKDEDCLE
       850        860        870        880        890        900
QQMPSLRESP MTLKELSLFN RKPLDLEKSS ESLASKLSRL KGSERETQTM GMMSRFNELP
       910        920        930        940        950        960
NSDSSRKDSK LCSVLTQDFC MLFNNKHEKT ENGVIPTSDS ATQDNSFNKN SKTHSNSNTT
       970        980        990       1000       1010       1020
ENCVISETPL VLPYNNSKVT GKDSDVLIRA SEQQIGSLDS PSGMLMNPVE DATGDQNGIC
      1030       1040       1050       1060       1070       1080
FQSEESKARA CSETEESNTC CSDWQRHFDV ALGRMVYVNK MTGLSTFIAP TEDIQAACTK
      1090       1100       1110       1120       1130       1140
DLTTVAVDVV LENGSQYRCQ PFRSDLVLPF LPRARAERTV MRQDNRDTVD DTVSSESLQS
      1150       1160       1170       1180       1190       1200
LFSEWDNPVF ARYPEVAVDV SSGQAESLAV KIHNILYPYR FTKGMIHSMQ VLQQVDNKFI
      1210       1220       1230       1240       1250       1260
ACLMSTKTEE NGEAGGNLLV LVDQHAAHER IRLEQLIIDS YEKQQAQGSG RKKLLSSTLI
      1270       1280       1290       1300       1310       1320
PPLEITVTEE QRRLLWCYHK NLEDLGLEFV FPDTSDSLVL VGKVPLCFVE REANELRRGR
      1330       1340       1350       1360       1370       1380
STVTKSIVEE FIREQLELLQ TTGGIQGTLP LTVQKVLASQ ACHGAIKFND GLSLQESCRL
      1390       1400       1410       1420       1430       1440
IEALSSCQLP FQCAHGRPSM LPLADIDHLE QEKQIKPNLT KLRKMAQAWR LFGKAECDTR
      1450
QSLQQSMPPC EPP    

Encoded by MLH3 gene

FULL NAME: mutL homolog 3 (E. coli)


OTHER NAME(S):
HNPCC7
MGC138372


DESCRIPTION:
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgatcaagt gcttgtcagt tgaagtacaa gccaaattgc gttctggttt ggccataagc
        70         80         90        100        110        120
tccttgggcc aatgtgttga ggaacttgcc ctcaacagta ttgatgctga agcaaaatgt
       130        140        150        160        170        180
gtggctgtca gggtgaatat ggaaaccttc caagttcaag tgatagacaa tggatttggg
       190        200        210        220        230        240
atggggagtg atgatgtaga gaaagtggga aatcgttatt tcaccagtaa atgccactcg
       250        260        270        280        290        300
gtacaggact tggagaatcc aaggttttat ggtttccgag gagaggcctt ggcaaatatt
       310        320        330        340        350        360
gctgacatgg ccagtgctgt ggaaatttcg tccaagaaaa acaggacaat gaaaactttt
       370        380        390        400        410        420
gtgaaactgt ttcagagtgg aaaagccctg aaagcttgtg aagctgatgt gactagagca
       430        440        450        460        470        480
agcgctggga ctactgtaac agtgtataac ctattttacc agcttcctgt aaggaggaaa
       490        500        510        520        530        540
tgcatggacc ctagactgga gtttgagaag gttaggcaga gaatagaagc tctctcactc
       550        560        570        580        590        600
atgcaccctt ccatttcttt ctctttgaga aatgatgttt ctggttccat ggttcttcag
       610        620        630        640        650        660
ctccctaaaa ccaaagacgt atgttcccga ttttgtcaaa tttatggatt gggaaagtcc
       670        680        690        700        710        720
caaaagctaa gagaaataag ttttaaatat aaagagtttg agcttagtgg ctatatcagc
       730        740        750        760        770        780
tctgaagcac attacaacaa gaatatgcag tttttgtttg tgaacaaaag actagtttta
       790        800        810        820        830        840
aggacaaagc tacataaact cattgacttt ttattaagga aagaaagtat tatatgcaag
       850        860        870        880        890        900
ccaaagaatg gtcccaccag taggcaaatg aattcaagtc ttcggcaccg gtctacccca
       910        920        930        940        950        960
gaactctatg gcatatatgt aattaatgtg cagtgccaat tctgtgagta tgatgtgtgc
       970        980        990       1000       1010       1020
atggagccag ccaaaactct gattgaattt cagaactggg acactctctt gttttgcatt
      1030       1040       1050       1060       1070       1080
caggaaggag tgaaaatgtt tttaaagcaa gaaaaattat ttgtggaatt atcaggtgag
      1090       1100       1110       1120       1130       1140
gatattaagg aatttagtga agataatggt tttagtttat ttgatgctac tcttcagaag
      1150       1160       1170       1180       1190       1200
cgtgtgactt ccgatgagag gagcaatttc caggaagcat gtaataatat tttagattcc
      1210       1220       1230       1240       1250       1260
tatgagatgt ttaatttgca gtcaaaagct gtgaaaagaa aaactactgc agaaaacgta
      1270       1280       1290       1300       1310       1320
aacacacaga gttctaggga ttcagaagct accagaaaaa atacaaatga tgcatttttg
      1330       1340       1350       1360       1370       1380
tacatttatg aatcaggtgg tccaggccat agcaaaatga cagagccatc tttacaaaac
      1390       1400       1410       1420       1430       1440
aaagacagct cttgctcaga atcaaagatg ttagaacaag agacaattgt agcatcagaa
      1450       1460       1470       1480       1490       1500
gctggagaaa atgagaaaca taaaaaatct ttcctggaac atagctcttt agaaaatccg
      1510       1520       1530       1540       1550       1560
tgtggaacca gtttagaaat gtttttaagc ccttttcaga caccatgtca ctttgaggag
      1570       1580       1590       1600       1610       1620
agtgggcagg atctagaaat atggaaagaa agtactactg ttaatggcat ggctgccaac
      1630       1640       1650       1660       1670       1680
atcttgaaaa ataatagaat tcagaatcaa ccaaagagat ttaaagatgc tactgaagtg
      1690       1700       1710       1720       1730       1740
ggatgccagc ctctgccttt tgcaacaaca ttatggggag tacatagtgc tcagacagag
      1750       1760       1770       1780       1790       1800
aaagagaaaa aaaaagaatc tagcaattgt ggaagaagaa atgtttttag ttatgggcga
      1810       1820       1830       1840       1850       1860
gttaaattat gttccactgg ctttataact catgtagtac aaaatgaaaa aactaaatca
      1870       1880       1890       1900       1910       1920
actgaaacag aacattcatt taaaaattat gttagacctg gtcccacacg tgcccaagaa
      1930       1940       1950       1960       1970       1980
acatttggaa atagaacacg tcattcagtt gaaactccag acatcaaaga tttagccagc
      1990       2000       2010       2020       2030       2040
actttaagta aagaatctgg tcaattgccc aacaaaaaaa attgcagaac gaatataagt
      2050       2060       2070       2080       2090       2100
tatgggctag agaatgaacc tacagcaact tatacaatgt tttctgcttt tcaggaaggt
      2110       2120       2130       2140       2150       2160
agcaaaaaat cacaaacaga ttgcatatta tctgatacat ccccctcttt cccctggtat
      2170       2180       2190       2200       2210       2220
agacacgttt ccaatgatag taggaaaaca gataaattaa ttggtttctc caaaccaatc
      2230       2240       2250       2260       2270       2280
gtccgtaaga agctaagctt gagttcacag ctaggatctt tagagaagtt taagaggcaa
      2290       2300       2310       2320       2330       2340
tatgggaagg ttgaaaatcc tctggataca gaagtagagg aaagtaatgg agtcactacc
      2350       2360       2370       2380       2390       2400
aatctcagtc ttcaagttga acctgacatt ctgctgaagg acaagaaccg cttagagaac
      2410       2420       2430       2440       2450       2460
tctgatgttt gtaaaatcac tactatggag catagtgatt cagatagtag ttgtcaacca
      2470       2480       2490       2500       2510       2520
gcaagccaca tccttaactc agagaagttt ccattctcca aggatgaaga ttgtttagaa
      2530       2540       2550       2560       2570       2580
caacagatgc ctagtttgag agaaagtcct atgaccctga aggagttatc tctctttaat
      2590       2600       2610       2620       2630       2640
agaaaacctt tggaccttga gaagtcatct gaatcactag cctctaaatt atccagactg
      2650       2660       2670       2680       2690       2700
aagggttccg aaagagaaac tcaaacaatg gggatgatga gtcgttttaa tgaacttcca
      2710       2720       2730       2740       2750       2760
aattcagatt ccagtaggaa agacagcaag ttgtgcagtg tgttaacaca agatttttgt
      2770       2780       2790       2800       2810       2820
atgttattta acaacaagca tgaaaaaaca gagaatggtg tcatcccaac atcagattct
      2830       2840       2850       2860       2870       2880
gccacacagg ataattcctt taataaaaat agtaaaacac attctaacag caatacaaca
      2890       2900       2910       2920       2930       2940
gagaactgtg tgatatcaga aactcctttg gtattgccct ataataattc taaagttacc
      2950       2960       2970       2980       2990       3000
ggtaaagatt cagatgttct tatcagagcc tcagaacaac agataggaag tcttgactct
      3010       3020       3030       3040       3050       3060
cccagtggaa tgttaatgaa tccggtagaa gatgccacag gtgaccaaaa tggaatttgt
      3070       3080       3090       3100       3110       3120
tttcagagtg aggaatctaa agcaagagct tgttctgaaa ctgaagagtc aaacacgtgt
      3130       3140       3150       3160       3170       3180
tgttcagatt ggcagcggca tttcgatgta gccctgggaa gaatggttta tgtcaacaaa
      3190       3200       3210       3220       3230       3240
atgactggac tcagcacatt cattgcccca actgaggaca ttcaggctgc ttgtactaaa
      3250       3260       3270       3280       3290       3300
gacctgacaa ctgtggctgt ggatgttgta cttgagaatg ggtctcagta caggtgtcaa
      3310       3320       3330       3340       3350       3360
ccttttagaa gcgaccttgt tcttcctttc cttccgagag ctcgagcaga gaggactgtg
      3370       3380       3390       3400       3410       3420
atgagacagg ataacagaga tactgtggat gatactgtta gtagcgaatc gcttcagtct
      3430       3440       3450       3460       3470       3480
ttgttctcag aatgggacaa tccagtattt gcccgttatc cagaggttgc tgttgatgta
      3490       3500       3510       3520       3530       3540
agcagtggcc aggctgagag cttagcagtt aaaattcaca acatcttgta tccctatcgt
      3550       3560       3570       3580       3590       3600
ttcaccaaag gaatgattca ttcaatgcag gttctccagc aagtagataa caagtttatt
      3610       3620       3630       3640       3650       3660
gcctgtttga tgagcactaa gactgaagag aatggcgagg caggtgggaa cctgctcgtg
      3670       3680       3690       3700       3710       3720
ctggtggatc agcacgctgc ccatgagcgt atacgtctgg agcagcttat cattgattcc
      3730       3740       3750       3760       3770       3780
tacgagaagc aacaggcaca aggctctggt cggaaaaaat tactgtcttc tactctaatt
      3790       3800       3810       3820       3830       3840
cctccgctag agataacagt gacagaggaa caaaggagac tcttatggtg ttaccacaaa
      3850       3860       3870       3880       3890       3900
aatctggaag atctgggcct tgaatttgta tttccagaca ctagtgattc tctggtcctt
      3910       3920       3930       3940       3950       3960
gtgggaaaag taccactatg ttttgtggaa agagaagcca atgaacttcg gagaggaaga
      3970       3980       3990       4000       4010       4020
tctactgtga ccaagagtat tgtggaggaa tttatccgag aacaactgga gctactccag
      4030       4040       4050       4060       4070       4080
accaccggag gcatccaagg gacattgcca ctgactgtcc agaaggtgtt ggcatcccaa
      4090       4100       4110       4120       4130       4140
gcctgccatg gggccattaa gtttaatgat ggcctgagct tacaggaaag ttgccgcctt
      4150       4160       4170       4180       4190       4200
attgaagctc tgtcctcatg ccagctgcca ttccagtgtg ctcacgggag accttctatg
      4210       4220       4230       4240       4250       4260
ctgccgttag ctgacataga ccacttggaa caggaaaaac agattaaacc caacctcact
      4270       4280       4290       4300       4310       4320
aaacttcgca aaatggccca ggcctggcgt ctctttggaa aagcagagtg tgatacaagg
      4330       4340       4350       4360
cagagcctgc agcaatccat gcctccctgt gagccaccat ga 

Last modification date: Oct. 2, 2011