Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: General transcription factor IIH subunit 1


DESCRIPTION:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (By similarity).

STRUCTURE SIMILARITY:
Contains 2 BSD domains.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MTTSSEDVLL QMGEVRYKKG DGTLYVMNER VAWMAEHRDT VTVSHRYADI KTQKISPEGK
        70         80         90        100        110        120
PKVQLQVVLH DGNTSTFHFV NRQGQAAMLA DRDKVKELLQ QLLPNFKRKV DKDLEDKNRI
       130        140        150        160        170        180
LVENPNLLQL YKDLVITKVL TSDEFWATHA KDHALKKMGR SQEIGVSGAF LADIKPQTDG
       190        200        210        220        230        240
CNGLKYNLTS DVIHCIFKTY PAVKRKHFEN VPAKMSEAEF WTKFFQSHYF HRDRLTAGTK
       250        260        270        280        290        300
DIFTECGKID DQALKAAVQQ GAGDPLLDLK KFEDVPLEEG FGSVAGDRNV VNSGNIVHQN
       310        320        330        340        350        360
MIKRFNQHSI MVLKTCANVT SAPSTMTNGT NNANGPVSQS AYTNGMNGKG QATATATKSS
       370        380        390        400        410        420
SDQVDKDEPQ SKKQRLMEKI HYVDLGDPIL EGDDSANGEK AKSKHFELSK VERYLNGPVQ
       430        440        450        460        470        480
NSMYDNHNDP MSLEEVQYKL VRNSESWLNR NVQRTFICSK AAVNALGELS PGGSMMRGFQ
       490        500        510        520        530        540
EQSAGQLVPN DFQRELRHLY LSLSELLKHF WSCFPPTSEE LETKLQRMHE TLQRFKMAKL
       550        560        570        580
VPFENRAMHE LSPLRSSLTQ HLNQLLRTAN SKFATWKERK LRNTR 

Encoded by Tfb1 gene


OTHER NAME(S):
CG8151
Dmel\CG8151
Dmp62
l(2)06949
l(2)06950
TFB1
TfBl


Nucleic acid sequence

        10         20         30         40         50         60
atgaccacca gcagtgagga cgtgctgctc cagatgggcg aggtgcggta caagaagggc
        70         80         90        100        110        120
gacggcacgc tctacgtaat gaatgagcgt gtggcctgga tggcggaaca ccgggacacg
       130        140        150        160        170        180
gtaacagtct cccatcgtta tgcggatatc aagactcaaa agatatctcc tgagggcaag
       190        200        210        220        230        240
cccaaggtgc agctgcaagt ggttcttcac gacggcaaca catcgacctt ccacttcgtc
       250        260        270        280        290        300
aaccgccagg gacaggccgc aatgcttgcc gacagggaca aggtcaagga gctattgcag
       310        320        330        340        350        360
caactgcttc ccaacttcaa gcggaaggtg gacaaagacc tggaagacaa gaaccgcatc
       370        380        390        400        410        420
cttgttgaga atcccaacct gctgcaactc tacaaggacc ttgtcataac caaagtccta
       430        440        450        460        470        480
accagcgatg agttctgggc tacgcatgcc aaggatcacg cccttaagaa aatgggcaga
       490        500        510        520        530        540
tcccaggaga tcggtgtttc tggcgccttt ctggctgaca taaagccgca gacagacggc
       550        560        570        580        590        600
tgtaatggcc tcaagtacaa cctcacctct gatgtgattc actgcatttt caagacctat
       610        620        630        640        650        660
cccgccgtta aacgcaaaca ttttgagaat gtgcctgcca aaatgtccga ggccgagttt
       670        680        690        700        710        720
tggaccaagt ttttccaatc acactacttt catcgtgaca gactgacagc cggcacaaag
       730        740        750        760        770        780
gacatattca cggagtgcgg caagatcgat gaccaagcat taaaagcggc tgttcagcag
       790        800        810        820        830        840
ggagctggtg atcctttgct agaccttaaa aagtttgagg atgttccttt ggaagagggc
       850        860        870        880        890        900
tttggcagcg tagcagggga ccgcaacgtc gtgaacagcg ggaatattgt gcaccaaaac
       910        920        930        940        950        960
atgatcaagc gattcaatca gcattccatc atggtgctta agacctgtgc taacgtgacc
       970        980        990       1000       1010       1020
tcagcgccgt caactatgac caatggtacc aataatgcca acgggcctgt ttcccaatcc
      1030       1040       1050       1060       1070       1080
gcgtatacga acgggatgaa tggaaagggc caggccacgg ccaccgcgac gaagagttcc
      1090       1100       1110       1120       1130       1140
tccgatcagg tggacaaaga cgagccgcag agcaaaaagc aacgactgat ggaaaagatt
      1150       1160       1170       1180       1190       1200
cactatgtgg atctcgggga ccctatattg gagggagatg attccgccaa cggcgagaaa
      1210       1220       1230       1240       1250       1260
gccaagtcta agcacttcga actgtccaaa gtggagcgtt acctcaatgg ccctgtccag
      1270       1280       1290       1300       1310       1320
aacagcatgt acgacaacca caacgatcca atgagtcttg aagaggtgca gtacaagctg
      1330       1340       1350       1360       1370       1380
gtgcggaatt cggagtcatg gctaaaccgc aacgtgcaac gaacgttcat ctgttctaag
      1390       1400       1410       1420       1430       1440
gcggcagtaa atgctctggg tgaactaagt cctggcggtt ccatgatgcg cggtttccaa
      1450       1460       1470       1480       1490       1500
gagcagtcag cgggacaact tgttccgaac gacttccaac gagagctgcg ccacttatac
      1510       1520       1530       1540       1550       1560
ctttcgctgt ccgagctgct gaaacacttt tggagctgct ttccgcccac ctcagaagag
      1570       1580       1590       1600       1610       1620
ctggagacaa agttacagcg tatgcacgag acgttgcagc gcttcaaaat ggccaaacta
      1630       1640       1650       1660       1670       1680
gtgccttttg agaaccgcgc tatgcacgaa ctttcgccac tgcgatcctc gctgacgcag
      1690       1700       1710       1720       1730       1740
cacttgaatc agctgctgcg caccgccaac agcaagttcg caacttggaa ggagcgaaaa
      1750
ctgcgcaaca ccaggtag    

Last modification date: Oct. 2, 2011