Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit chi


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MKNATFYLLD NDTTVDGLSA VEQLVCEIAA ERWRSGKRVL IACEDEKQAY RLDEALWARP
        70         80         90        100        110        120
AESFVPHNLA GEGPRGGAPV EIAWPQKRSS SRRDILISLR TSFADFATAF TEVVDFVPYE
       130        140
DSLKQLARER YKAYRVAGFN LNTATWK   

Encoded by holC gene


OTHER NAME(S):
ECK4252
JW4216


DESCRIPTION:
The preinitiation complex binds primed ssDNA and loads the beta processivity clamp. [More information is available at EcoCyc: EG11413].


Nucleic acid sequence

        10         20         30         40         50         60
atgaaaaacg cgacgttcta ccttctggac aatgacacca ccgtcgatgg cttaagcgcc
        70         80         90        100        110        120
gttgagcaac tggtgtgtga aattgccgca gaacgttggc gcagcggtaa gcgcgtgctc
       130        140        150        160        170        180
atcgcctgtg aagatgaaaa gcaggcttac cggctggatg aagccctgtg ggcgcgtccg
       190        200        210        220        230        240
gcagaaagct ttgttccgca taatttagcg ggagaaggac cgcgcggcgg tgcaccggtg
       250        260        270        280        290        300
gagatcgcct ggccgcaaaa gcgtagcagc agccggcgcg atatattgat tagtctgcga
       310        320        330        340        350        360
acaagctttg cagattttgc caccgctttc acagaagtgg tagacttcgt tccttatgaa
       370        380        390        400        410        420
gattctctga aacaactggc gcgcgaacgc tataaagcct accgcgtggc tggtttcaac
       430        440
ctgaatacgg caacctggaa ataa   

Last modification date: Oct. 2, 2011