Homo sapiens L. (human) [HSA]

FULL NAME: ATPase WRNIP1


DESCRIPTION:
Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.

STRUCTURE SIMILARITY:
Contains 1 UBZ-type zinc finger.
Belongs to the AAA ATPase family.


POST-TRANSLATIONAL MODIFICATION:
Sumoylated by SUMO1 and SUMO2/3.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP AAGSHRAGER
        70         80         90        100        110        120
AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD DGGETESRES YDAPPTPSGA
       130        140        150        160        170        180
RLIPDFPVAR SSSPGRKGSG KRPAAAAAAG SASPRSWDEA EAQEEEEAVG DGDGDGDADA
       190        200        210        220        230        240
DGEDDPGHWD ADAAEAATAF GASGGGRPHP RALAAEEIRQ MLQGKPLADT MRPDTLQDYF
       250        260        270        280        290        300
GQSKAVGQDT LLRSLLETNE IPSLILWGPP GCGKTTLAHI IASNSKKHSI RFVTLSATNA
       310        320        330        340        350        360
KTNDVRDVIK QAQNEKSFFK RKTILFIDEI HRFNKSQQDT FLPHVECGTI TLIGATTENP
       370        380        390        400        410        420
SFQVNAALLS RCRVIVLEKL PVEAMVTILM RAINSLGIHV LDSSRPTDPL SHSSNSSSEP
       430        440        450        460        470        480
AMFIEDKAVD TLAYLSDGDA RAGLNGLQLA VLARLSSRKM FCKKSGQSYS PSRVLITEND
       490        500        510        520        530        540
VKEGLQRSHI LYDRAGEEHY NCISALHKSM RGSDQNASLY WLARMLEGGE DPLYVARRLV
       550        560        570        580        590        600
RFASEDIGLA DPSALTQAVA AYQGCHFIGM PECEVLLAQC VVYFARAPKS IEVYSAYNNV
       610        620        630        640        650        660
KACLRNHQGP LPPVPLHLRN APTRLMKDLG YGKGYKYNPM YSEPVDQEYL PEELRGVDFF

KQRRC     

Encoded by WRNIP1 gene

FULL NAME: Werner helicase interacting protein 1


OTHER NAME(S):
WHIP
FLJ22526
bA420G6.2
RP11-420G6.2


DESCRIPTION:
Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggaggtga gcgggccgga agacgacccc ttcctttcgc agctgcacca ggtgcagtgc
        70         80         90        100        110        120
cccgtgtgcc agcagatgat gcccgccgcg cacatcaact cgcacctgga ccgctgtctg
       130        140        150        160        170        180
ctgctccacc cggcggggca cgcggagccc gcggccgggt cgcaccgcgc cggggagcgg
       190        200        210        220        230        240
gccaaggggc cctcgccgcc cggcgccaag aggcggcggc tgtcggagag ctcggcgctg
       250        260        270        280        290        300
aagcagccag ccaccccgac ggcagccgag agcagcgagg gcgagggtga ggagggcgac
       310        320        330        340        350        360
gacggcggcg agaccgagag ccgcgagagc tacgacgcgc cgcccacacc cagcggcgcc
       370        380        390        400        410        420
cgccttatcc ccgacttccc ggtggcccgc tccagcagcc ccgggaggaa ggggtcgggg
       430        440        450        460        470        480
aagaggccgg cggccgccgc cgcggcgggg agcgcgtctc cgcgcagctg ggacgaggcg
       490        500        510        520        530        540
gaggcgcagg aggaggagga ggccgtgggc gacggcgatg gcgacgggga cgcggacgcg
       550        560        570        580        590        600
gacggcgagg acgacccggg gcactgggac gcggacgctg ccgaagccgc caccgccttc
       610        620        630        640        650        660
ggggccagtg gcgggggccg cccgcacccc cgggcgctgg ctgccgagga gatccgacag
       670        680        690        700        710        720
atgctacagg gcaagccgct ggccgacacg atgcgtcctg acacgctgca ggattacttc
       730        740        750        760        770        780
gggcagagca aggccgtggg ccaggatacc ctgctgcgct cgctcctgga gaccaacgaa
       790        800        810        820        830        840
atcccctcgc ttatcctgtg ggggccgccg ggctgcggca agaccactct ggctcacatc
       850        860        870        880        890        900
atagccagca acagcaagaa acatagcata aggtttgtga cattatctgc aacaaatgcc
       910        920        930        940        950        960
aagacaaatg atgtgcgaga tgtcataaaa caagctcaaa atgaaaagag ctttttcaaa
       970        980        990       1000       1010       1020
aggaaaacca tcctttttat tgatgagatt catcggttca ataaatctca gcaggacact
      1030       1040       1050       1060       1070       1080
ttccttcctc acgtggaatg tgggacgatc actctgattg gggcaaccac tgaaaaccct
      1090       1100       1110       1120       1130       1140
tccttccagg tcaacgctgc tcttctgagc cgctgtcgag tgattgttct tgagaagctt
      1150       1160       1170       1180       1190       1200
ccagtagagg caatggtgac tattttaatg cgagcgatca actccctggg aatccacgtc
      1210       1220       1230       1240       1250       1260
ctagactcta gccgtcccac tgaccctctg agccacagca gcaacagcag ctcagagccc
      1270       1280       1290       1300       1310       1320
gccatgttca tagaggataa agcagtagac accctggctt acctcagtga cggtgacgcc
      1330       1340       1350       1360       1370       1380
cgagctgggt tgaacggact gcagctggcg gtgctggcta ggttaagctc taggaagatg
      1390       1400       1410       1420       1430       1440
ttctgtaaga agagtgggca atcctattct cccagtagag ttctgatcac agagaatgac
      1450       1460       1470       1480       1490       1500
gtgaaggagg gcctacagcg atcccacatt ttatatgacc gggcaggtga ggagcattac
      1510       1520       1530       1540       1550       1560
aactgcatct ccgccctgca caagtccatg cggggctcag accagaacgc ctccctctac
      1570       1580       1590       1600       1610       1620
tggctggctc gcatgctcga gggaggagag gacccactct acgtggcacg gaggcttgtc
      1630       1640       1650       1660       1670       1680
aggtttgcca gcgaggacat aggtctggca gacccgtctg cgttaacaca agcggttgct
      1690       1700       1710       1720       1730       1740
gcctaccaag gctgtcattt tataggcatg cctgaatgtg aggtgcttct ggcccagtgt
      1750       1760       1770       1780       1790       1800
gtggtctact ttgccagagc cccaaagtcc attgaggtgt acagcgccta caacaacgtc
      1810       1820       1830       1840       1850       1860
aaagcctgcc tgaggaacca ccaggggcca ctgccccccg tgcccctgca cctgaggaac
      1870       1880       1890       1900       1910       1920
gcgcccacta ggctgatgaa ggatttgggc tatggcaaag gctacaagta caaccccatg
      1930       1940       1950       1960       1970       1980
tacagcgagc ctgtggatca ggagtacctg cctgaagagt tgaggggggt agatttcttc
      1990
aagcagagga ggtgctga    

Last modification date: Oct. 2, 2011