Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: RING-box protein 1B


DESCRIPTION:
Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity).

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.
Belongs to the RING-box family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MAEEIEVEET EDFHDMDFND EEPSCSGGAV QARTERFVVK KWVAHAMWGW DVAVDNCAIC
        70         80         90        100        110        120
RNHIMNLCIE CQADPNANQD ECTVAWGECN HAFHYHCIAR WLKTRLVCPL DNKEWVYQKY

GR     

Encoded by Roc1b gene


OTHER NAME(S):
BcDNA:AT21612
CG16988
Dmel\CG16988
dRoc1b
Roc
roc1b
ROC1b
ROC1B
ROC2


Nucleic acid sequence

        10         20         30         40         50         60
atggccgagg agatagaggt tgaggagacg gaggacttcc acgacatgga cttcaatgac
        70         80         90        100        110        120
gaagagccat cctgtagtgg aggagctgtc caggccagga cggagcgctt tgtggtgaag
       130        140        150        160        170        180
aaatgggttg cgcacgccat gtggggatgg gacgtagcag tggacaactg tgccatctgc
       190        200        210        220        230        240
cgtaaccaca tcatgaacct gtgcatcgag tgccaggcgg acccgaatgc aaaccaagac
       250        260        270        280        290        300
gagtgcactg tggcttgggg cgagtgcaac cacgcattcc attaccactg catcgcgcgc
       310        320        330        340        350        360
tggttgaaaa cgcgcctggt ctgtccgctg gacaacaagg agtgggtcta ccagaagtac

ggccgctag     

Last modification date: Oct. 2, 2011