Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor TFIID subunit 3


DESCRIPTION:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

STRUCTURE SIMILARITY:
Contains 1 PHD-type zinc finger.
Belongs to the TAF3 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MCESYSRSLL RVSVAQICQA LGWDSVQLSA CHLLTDVLQR YLQQLGRGCH RYSELYGRTD
        70         80         90        100        110        120
PILDDVGEAF QLMGVSLHEL EDYIHNIEPV TFPHQIPSFP VSKNNVLQFP QPGSKDAEER
       130        140        150        160        170        180
KEYIPDYLPP IVSSQEEEEE EQVPTDGGTS AEAMQVPLEE DDELEEEEII NDENFLGKRP
       190        200        210        220        230        240
LDSPEAEELP AMKRPRLLST KGDTLDVVLL EAREPLSSIN TQKIPPMLSP VHVQDSTDLA
       250        260        270        280        290        300
PPSPEPPMLA PVAKSQMPTA KPLETKSFTP KTKTKTSSPG QKTKSPKTAQ SPAMVGSPIR
       310        320        330        340        350        360
SPKTVSKEKK SPGRSKSPKS PKSPKVTTHI PQTPVRPETP NRTPSATLSE KISKETIQVK
       370        380        390        400        410        420
QIQTPPDAGK LNSENQPKKA VVADKTIEAS IDAVIARACA EREPDPFEFS SGSESEGDIF
       430        440        450        460        470        480
TSPKRISGPE CTTPKASTSA NNFTKSGSTP LPLSGGTSSS DNSWTMDASI DEVVRKAKLG
       490        500        510        520        530        540
TPSNMPPNFP YISSPSVSPP TPEPLHKVYE EKTKLPSSVE VKKKLKKELK TKMKKKEKQR
       550        560        570        580        590        600
DREREKDKNK DKSKEKDKVK EKEKDKETGR ETKYPWKEFL KEEEADPYKF KIKEFEDVDP
       610        620        630        640        650        660
KVKLKDGLVR KEKEKHKDKK KDREKGKKDK DKREKEKVKD KGREDKMKAP APPLVLPPKE
       670        680        690        700        710        720
LALPLFSPAT ASRVPAMLPS LLPVLPEKLF EEKEKVKEKE KKKDKKEKKK KKEKEKEKKE
       730        740        750        760        770        780
KEREKEKRER EKREKEKEKH KHEKIKVEPV ALAPSPVIPR LTLRVGAGQD KIVISKVVPA
       790        800        810        820        830        840
PEAKPAPSQN RPKTPPPAPA PAPGPMLVSP APVPLPLLAQ AAAGPALLPS PGPAASGASA
       850        860        870        880        890        900
KAPVRSVVTE TVSTYVIRDE WGNQIWICPG CNKPDDGSPM IGCDDCDDWY HWPCVGIMTA
       910        920
PPEEMQWFCP KCANKKKDKK HKKRKHRAH   

Encoded by TAF3 gene

FULL NAME: TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa


OTHER NAME(S):
MGC25063
TAF140
TAFII-140
TAFII140


DESCRIPTION:
The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atgtgcgaga gttactccag gtcgttgttg agggtctcgg tggcgcagat ctgccaggcg
        70         80         90        100        110        120
ctgggctggg actcggtgca gctcagcgcc tgccacctcc tcacggacgt gctgcagcgc
       130        140        150        160        170        180
tatctgcagc agctgggccg gggctgccat cggtactctg agctctatgg ccgaacagac
       190        200        210        220        230        240
ccaattttgg atgatgttgg tgaagctttc cagctgatgg gggttagtct acatgaacta
       250        260        270        280        290        300
gaagactata ttcacaacat tgagcctgtc accttcccac accaaattcc gtcatttcct
       310        320        330        340        350        360
gttagcaaga acaatgtact tcagtttcct caacctggaa gtaaagatgc agaggaaaga
       370        380        390        400        410        420
aaagaataca ttcctgatta cctgccaccc attgtgtctt ctcaagaaga agaagaagaa
       430        440        450        460        470        480
gagcaggtgc ccactgatgg aggcacatca gcagaagcca tgcaggttcc cttggaagaa
       490        500        510        520        530        540
gatgatgaat tggaggagga agaaattatt aatgatgaga atttcctggg caagagacca
       550        560        570        580        590        600
ctggatagtc ctgaagctga agaactgcca gccatgaagc ggcctcggct attaagcact
       610        620        630        640        650        660
aaaggggaca cgctagatgt tgtgttattg gaagctcgag agccactcag ctcaataaat
       670        680        690        700        710        720
actcaaaaga tcccaccaat gctttctcca gtccatgtac aggacagtac agacttggca
       730        740        750        760        770        780
cctccctcac ccgagccgcc aatgttggct ccagttgcaa aatcacaaat gccaactgca
       790        800        810        820        830        840
aaaccattag aaacaaagtc atttacacct aaaacaaaga ctaaaactag ctctccagga
       850        860        870        880        890        900
cagaagacta aatcacctaa aaccgcccag tcaccagcaa tggtcggaag tcctattcga
       910        920        930        940        950        960
tcaccaaaaa ctgtatccaa agaaaagaaa tcacctggac gttccaagag ccccaagagt
       970        980        990       1000       1010       1020
cccaagagcc ccaaggtcac gactcacatt ccccaaacac ctgtgagacc tgaaacgccc
      1030       1040       1050       1060       1070       1080
aacaggactc cttcagctac actcagtgaa aaaatcagta aagagactat ccaggtaaaa
      1090       1100       1110       1120       1130       1140
caaatacaga caccccctga tgctgggaaa ctgaacagtg agaatcagcc gaaaaaggct
      1150       1160       1170       1180       1190       1200
gtggtagcag ataaaacgat tgaggcctct atcgatgctg tgattgcacg agcctgtgct
      1210       1220       1230       1240       1250       1260
gagcgagagc cagatccttt cgaattttct tctggatcgg aatctgaagg agacattttt
      1270       1280       1290       1300       1310       1320
actagcccta agagaatttc aggcccggag tgtactactc ccaaagcttc cacttccgcg
      1330       1340       1350       1360       1370       1380
aacaatttca caaagtcagg atccactcct ctgcctcttt ccggtggaac ctcaagttcc
      1390       1400       1410       1420       1430       1440
gataactcat ggacaatgga tgcctccatt gatgaggttg tacgtaaagc aaaactggga
      1450       1460       1470       1480       1490       1500
acaccttcaa atatgccccc caactttcct tatatctctt ctccgtcagt gtctcctccc
      1510       1520       1530       1540       1550       1560
actcccgaac ctctccacaa ggtgtatgag gagaaaacca agctgccttc ctccgtggag
      1570       1580       1590       1600       1610       1620
gtaaagaaga agttgaaaaa ggaactaaag actaaaatga aaaagaaaga aaagcagaga
      1630       1640       1650       1660       1670       1680
gatagggaga gggaaaaaga caagaacaag gacaaaagta aggagaagga taaagtgaaa
      1690       1700       1710       1720       1730       1740
gagaaagaga aagacaagga aactggcagg gaaacaaagt atccctggaa ggaatttctt
      1750       1760       1770       1780       1790       1800
aaagaggaag aggcagatcc ctacaagttt aaaatcaaag aatttgaaga tgttgatccc
      1810       1820       1830       1840       1850       1860
aaagtgaaat tgaaagatgg acttgtgagg aaggagaaag agaagcataa agataagaag
      1870       1880       1890       1900       1910       1920
aaagatagag agaaaggcaa gaaagataaa gataagagag agaaagaaaa agtgaaagat
      1930       1940       1950       1960       1970       1980
aaaggcagag aagataagat gaaagcccca gcacccccac tggtgttgcc cccaaaagag
      1990       2000       2010       2020       2030       2040
ttggccctgc ccttgttcag ccctgccaca gcctccaggg tcccagccat gctgccatct
      2050       2060       2070       2080       2090       2100
ttgttgccag tgcttccgga aaaactgttt gaggagaaag agaaggtgaa ggagaaagaa
      2110       2120       2130       2140       2150       2160
aagaaaaagg acaaaaagga gaagaagaaa aagaaggaaa aagagaagga gaagaaggag
      2170       2180       2190       2200       2210       2220
aaggaaagag agaaagagaa gagagagcga gagaagagag aaaaagagaa ggagaaacac
      2230       2240       2250       2260       2270       2280
aagcatgaaa aaataaaagt ggaaccagtc gctctggccc cgagtccagt tatccccaga
      2290       2300       2310       2320       2330       2340
ttaactctcc gagtcggtgc tggccaagac aagattgtca tcagcaaggt ggtccctgcc
      2350       2360       2370       2380       2390       2400
cccgaggcca agccggcgcc ctcgcagaac aggccgaaga ccccaccgcc ggcccccgcg
      2410       2420       2430       2440       2450       2460
cccgcccccg gccccatgct cgtcagccct gcgcccgtgc cgctgccgct gctcgcccag
      2470       2480       2490       2500       2510       2520
gccgccgcgg gccctgccct gctgccctcc ccgggtcccg ccgcctccgg ggccagtgcc
      2530       2540       2550       2560       2570       2580
aaagcccccg tgcgcagcgt ggtgactgag acggtcagca cctacgtgat ccgagatgag
      2590       2600       2610       2620       2630       2640
tggggcaatc agatctggat ctgccctggg tgtaacaagc ctgacgatgg gagtcccatg
      2650       2660       2670       2680       2690       2700
attgggtgtg acgactgcga tgactggtac cactggccct gtgttggaat catgactgca
      2710       2720       2730       2740       2750       2760
cccccagaag agatgcagtg gttctgcccc aagtgtgcga acaagaagaa ggacaaaaag
      2770       2780       2790
cacaagaaga ggaagcatcg agcccactga   

Last modification date: Oct. 2, 2011