Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor TFIID subunit 8


DESCRIPTION:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).

MISCELLANEOUS:
'Taube nuss' means "empty nut' in German.


STRUCTURE SIMILARITY:
Belongs to the TAF8 family.
Contains 1 histone-fold domain.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MADAAATAGA GGSGTRSGSK QSTNPADNYH LARRRTLQVV VSSLLTEAGF ESAEKASVET
        70         80         90        100        110        120
LTEMLQSYIS EIGRSAKSYC EHTARTQPTL SDIVVTLVEM GFNVDTLPAY AKRSQRMVIT
       130        140        150        160        170        180
APPVTNQPVT PKALTAGQNR PHPPHIPSHF PEFPDPHTYI KTPTYREPVS DYQVLREKAA
       190        200        210        220        230        240
SQRRDVERAL TRFMAKTGET QSLFKDDVST FPLIAARPFT IPYLTALLPS ELEMQQMEET
       250        260        270        280        290        300
DSSEQDEQTD TENLALHISM EDSGAEKENT SVLQQNPSLS GSRNGEENII DNPYLRPVKK
       310
PKIRRKKSLS     

Encoded by TAF8 gene

FULL NAME: TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa


OTHER NAME(S):
43
FLJ32821
II
TAF
TAFII-43
TAFII43
TBN


DESCRIPTION:
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggccgacg cggcggccac agctggggcc ggtggctccg gaacgagatc gggaagtaaa
        70         80         90        100        110        120
cagtccacta accctgccga taactatcat ctggcccgga ggagaaccct gcaggtggtt
       130        140        150        160        170        180
gtgagctcct tgctgacaga ggcagggttt gagagtgccg agaaagcatc cgtggaaacg
       190        200        210        220        230        240
ctgacagaga tgctgcagag ctacatttca gaaattggga gaagtgccaa gtcttactgt
       250        260        270        280        290        300
gagcacacag ccaggaccca gcccacactg tccgatatcg tggtcacact tgttgagatg
       310        320        330        340        350        360
ggtttcaatg tggacactct ccctgcttat gcaaaacggt ctcagaggat ggtcatcact
       370        380        390        400        410        420
gctcctccgg tgaccaatca gccagtgacc cccaaggccc tcactgcagg gcagaaccga
       430        440        450        460        470        480
ccccacccgc cgcacatccc cagccatttt cctgagttcc ctgatcccca cacctacatc
       490        500        510        520        530        540
aaaactccga cgtaccgtga gcccgtgtca gactaccagg tcctgcggga gaaggctgca
       550        560        570        580        590        600
tcccagaggc gcgatgtgga gcgggcactt acccgtttca tggccaagac aggcgagact
       610        620        630        640        650        660
cagagtcttt tcaaagatga cgtcagcaca tttccattga ttgctgccag acctttcacc
       670        680        690        700        710        720
atcccctacc tgacagctct tcttccgtct gaactggaga tgcaacaaat ggaagagaca
       730        740        750        760        770        780
gattcctcgg agcaggatga acagacagac acagagaacc ttgctcttca tatcagcatg
       790        800        810        820        830        840
gaggattctg gagccgagaa ggagaacacc tctgtcctgc agcagaaccc ctccttgtcg
       850        860        870        880        890        900
ggtagccgga atggggagga gaacatcatc gataaccctt atctgcggcc ggtgaagaag
       910        920        930
cccaagatcc gcaggaagaa gtccctctcc tga  

Last modification date: Oct. 2, 2011