Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA repair helicase XPB2


DESCRIPTION:
Putative ATP-dependent 3'-5' DNA helicase involved in nucleotide excision repair (NER) of DNA. May be involved in RNA transcription by RNA polymerase II. Acts by opening DNA around either the RNA transcription start site or the DNA damage (By similarity).

STRUCTURE SIMILARITY:
Contains 1 helicase C-terminal domain.
Contains 1 helicase ATP-binding domain.
Belongs to the helicase family. RAD25/XPB subfamily.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MGNDERKRPT KKMKYGGKDD QKMKNIQNVE DYYDDADEDS RDGEGEEKRR DFTDLELKPD
        70         80         90        100        110        120
HGNRPLWACA DGKIFLETFS PLYKQAYDFL IAIAEPVCRP ESMHEYNLTP HSLYAAVSVG
       130        140        150        160        170        180
LETETIISVL NKLSKTKLPG EIIDFIHAST ANYGKVKLVL KKNRYFIESP FPEVLKRLLS
       190        200        210        220        230        240
DDVINRARFT SEPYYGGDGF TIGKTSGELE AGPGELLNEA ELAAAAEEKE THSFEIDPAL
       250        260        270        280        290        300
VENVKQRCLP NALNYPMLEE YDFRNDNVNP DLDMELKPHA QPRPYQEKSL SKMFGNGRAR
       310        320        330        340        350        360
SGIIVLPCGA GKSLVGVSAA ARIKKSCLCL ATNAVSVDQW AYQFKLWSTI KDDQICRFTS
       370        380        390        400        410        420
DSKERFRGNA GVVVTTYNMI AFGGKRSEEA EKIIEEMRNR EWGLLLMDEV HVVPAHMFRK
       430        440        450        460        470        480
VISITKSHCK LGLTATLVRE DEKITDLNFL IGPKLYEANW LDLVKGGFIA NVQCAEVWCP
       490        500        510        520        530        540
MTKEFFAEYL KKENSKKKQA LYVMNPNKFR ACEFLIRFHE QQRGDKIIVF ADNLFALTEY
       550        560        570        580        590        600
AMKLRKPMIY GATSHIERTK ILEAFKTSKT VNTVFLSKVG DNSIDIPEAN VIIQISSHAG
       610        620        630        640        650        660
SRRQEAQRLG RILRAKGKLE DRMAGGKEEY NAFFYSLVST DTQEMYYSTK RQQFLIDQGY
       670        680        690        700        710        720
SFKVITSLPP PDAGSSLGYH SQEEQLSLLG KVLNAGDDMV GLEQLEEDTD GKALKTRRSM
       730        740        750        760
GSMSAMSGAN GRVYMEYNSG RQKSGNQSKK PKDPTKRHNI FKKRYV 

Encoded by XPB2 gene


OTHER NAME(S):
ARABIDOPSIS HOMOLOG OF XERODERMA PIGMENTOSUM COMPLEMENTATION GROUP B 2
ATXPB2
homolog of Xeroderma pigmentosum complementation group B 2
MYC6.7
MYC6_7
XPB2


Nucleic acid sequence

        10         20         30         40         50         60
atgggaaacg atgaaagaaa acgacctaca aagaagatga agtacggtgg gaaggatgat
        70         80         90        100        110        120
caaaagatga agaacataca aaacgttgaa gattactatg atgatgctga tgaggattct
       130        140        150        160        170        180
cgtgatggtg aaggagagga gaagaggaga gattttactg atttggagtt gaagccggat
       190        200        210        220        230        240
catggaaata ggcctttgtg ggcttgtgct gatggaaaga ttttcttgga gacattttct
       250        260        270        280        290        300
cctctctata aacaagctta tgactttctt atcgccattg ctgaacccgt ttgcaggcct
       310        320        330        340        350        360
gagtcaatgc acgagtataa tttaacccca cactcgttgt atgctgctgt ttccgttggt
       370        380        390        400        410        420
cttgagacag aaactatcat ctctgttttg aataagctat ctaagaccaa gctacccggg
       430        440        450        460        470        480
gagatcattg atttcatcca tgcttctact gctaattatg ggaaagtgaa gttggtattg
       490        500        510        520        530        540
aagaaaaatc ggtattttat tgaatcacca ttcccggagg tgttgaaaag gcttctcagt
       550        560        570        580        590        600
gatgatgtca taaatcgagc aagatttact tctgagccat attatggtgg tgatggattt
       610        620        630        640        650        660
acgatcggca aaacaagtgg tgaacttgaa gcaggacctg gggagttgtt gaatgaagca
       670        680        690        700        710        720
gaattggcag cagcagcaga agagaaagaa actcactcat ttgagataga ccctgcactg
       730        740        750        760        770        780
gtggagaatg ttaagcagcg ttgcttgcca aatgccttga attaccctat gttagaggaa
       790        800        810        820        830        840
tatgacttca ggaacgataa tgttaatcct gatcttgaca tggaactgaa gccccatgca
       850        860        870        880        890        900
caaccaaggc cataccagga aaaaagtttg agcaaaatgt ttggaaacgg acgagcaaga
       910        920        930        940        950        960
tctgggatta tagtgttacc ttgtggagct ggtaaatctc tagttggtgt ttctgcagcg
       970        980        990       1000       1010       1020
gctcgtataa agaagagttg tctttgtttg gcaacgaatg ctgtctcggt ggatcaatgg
      1030       1040       1050       1060       1070       1080
gcctaccaat ttaagttgtg gtctactata aaagatgacc aaatatgccg tttcacttct
      1090       1100       1110       1120       1130       1140
gatagtaaag aacgattccg tggaaatgct ggtgttgttg tgacaaccta taatatgatt
      1150       1160       1170       1180       1190       1200
gcctttggtg gtaaacgatc tgaagaagca gagaagatta tagaagaaat gagaaacaga
      1210       1220       1230       1240       1250       1260
gagtgggggt tgctgcttat ggacgaggtg catgtggttc cagcccatat gtttaggaaa
      1270       1280       1290       1300       1310       1320
gttatcagta ttacaaaatc tcactgcaag ctaggactta cagccaccct tgtgagagaa
      1330       1340       1350       1360       1370       1380
gacgaaaaaa ttacagattt aaacttcctc attggcccga aactctatga agccaattgg
      1390       1400       1410       1420       1430       1440
ctagatttag ttaaaggagg ctttattgca aatgttcagt gtgctgaagt atggtgtccc
      1450       1460       1470       1480       1490       1500
atgaccaaag agttttttgc agaatatctg aagaaagaga actcgaaaaa aaaacaggcg
      1510       1520       1530       1540       1550       1560
ctttatgtca tgaaccctaa caagttcaga gcctgtgaat ttttgatacg tttccatgaa
      1570       1580       1590       1600       1610       1620
caacaacgtg gggataaaat catcgtcttt gcagacaatc tttttgcact tacagagtat
      1630       1640       1650       1660       1670       1680
gcaatgaaac tccggaaacc gatgatttac ggtgcaacca gccatatcga acgaacaaaa
      1690       1700       1710       1720       1730       1740
attctcgagg cgtttaaaac cagtaaaacc gtgaacactg tattcctgtc aaaggttggt
      1750       1760       1770       1780       1790       1800
gataactcca tagatatccc tgaagcgaat gtgatcatcc agatttcgtc acatgctggt
      1810       1820       1830       1840       1850       1860
tctagacgtc aagaggctca acgtttgggt cgtatcctta gggctaaggg taaacttgaa
      1870       1880       1890       1900       1910       1920
gatagaatgg ctggtggaaa agaagagtac aatgcattct tctactcgct tgtttctacc
      1930       1940       1950       1960       1970       1980
gatacacagg aaatgtatta ttcaacgaaa agacagcagt ttttgatcga ccaaggttat
      1990       2000       2010       2020       2030       2040
agcttcaagg taataacaag cctcccacct ccggacgcgg gttcaagctt gggctaccac
      2050       2060       2070       2080       2090       2100
agtcaagaag aacagttgtc tcttctcgga aaggtgttga atgctggaga cgatatggtt
      2110       2120       2130       2140       2150       2160
ggtttagaac aacttgaaga agacacagat ggaaaggctc taaagacgcg acgaagcatg
      2170       2180       2190       2200       2210       2220
ggatcgatga gtgcaatgtc cggtgcaaat ggaagggtct acatggaata caactcaggt
      2230       2240       2250       2260       2270       2280
cgtcaaaaat ctggtaacca atccaagaaa cctaaagacc caaccaaacg acacaatatc
      2290       2300
ttcaaaaaac gttatgtttg a   

Last modification date: Oct. 2, 2011