Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Transcription initiation factor TFIID subunit 14


DESCRIPTION:
Functions as a component of the DNA-binding general transcription factor complex TFIID, and the RNA polymerase II associated general transcription factor complex TFIIF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, facilitation of DNA opening and initiation of transcription. TFIIF is essential for the initiation of transcription by RNA polymerase II. TFIIF functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation. The TAF14 subunit has stimulatory activity. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.

STRUCTURE SIMILARITY:
Contains 1 YEATS domain.
Belongs to the TAF14 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MTTVKRTVRL ITDQNVLPGG EAAVLNDQSF PVREWSIKLV CLNPQGEETD ASFVDRVTYK
        70         80         90        100        110        120
LHPTFQNPTR TIRKPPFQIK EQGWGEFEME IIIYYADKGG EHRFLHYLHF QQEHYHEDIE
       130        140        150        160        170        180
LNINATRPGL LKALTATGEV PGYSDEGEEA RKDKRKNESE VGAGKKKAKA KPVDMDKLAE
       190        200        210        220        230        240
GLQKLQEDDL LQVVQMVNEN KTPDMYVRND IEGGEFHIDL YTLPDNLLLL LYSFCAKRVT

M     

Encoded by tfg3 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgacaactg tgaaaagaac tgtgagatta attactgatc agaatgtgtt gccgggaggt
        70         80         90        100        110        120
gaagcagctg tgttgaacga tcaaagcttc cctgtgaggg aatggtctat aaaattggtc
       130        140        150        160        170        180
tgcttaaatc ctcagggaga agaaactgac gcttcctttg ttgatcgtgt cacctataag
       190        200        210        220        230        240
ctacatccaa catttcaaaa tcctacacgc actatcagaa aacctccttt ccaaataaaa
       250        260        270        280        290        300
gagcaaggat ggggtgagtt tgaaatggag atcataatat actatgcgga caaaggtggt
       310        320        330        340        350        360
gaacatcggt tccttcacta tttacatttt cagcaggagc attatcatga ggatatcgaa
       370        380        390        400        410        420
ttgaatatca atgctactag gccaggttta ttaaaggcac tgacagccac tggagaagta
       430        440        450        460        470        480
cctggctaca gtgatgaagg tgaagaagct cgtaaggata aaagaaaaaa cgaatcagaa
       490        500        510        520        530        540
gttggtgctg ggaagaaaaa ggcgaaagct aaacctgttg acatggataa acttgcagag
       550        560        570        580        590        600
ggtttgcaaa aacttcagga ggatgacttg ttacaagttg tgcagatggt gaatgagaac
       610        620        630        640        650        660
aaaacaccag acatgtatgt ccgaaacgac attgaagggg gtgaattcca tattgactta
       670        680        690        700        710        720
tatactctgc cggacaatct tctgctctta ttatacagtt tctgtgctaa acgcgtcact

atgtaa     

Last modification date: Oct. 2, 2011