Mus musculus L. (mouse) [MMU]

FULL NAME: General transcription factor IIF subunit 1


DESCRIPTION:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity).

STRUCTURE SIMILARITY:
Belongs to the TFIIF alpha subunit family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases (By similarity).


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MAALGSSSQN VTEYVVRVPK NTAKRYNIMA FNAADKVNFA TWNQARLERD LSNKKIYQEE
        70         80         90        100        110        120
EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL RVNGKSGRKF KGIKKGGVTE
       130        140        150        160        170        180
NTAYYIFTQC ADGAFEAFPV QNWYNFTPLA RHRTLTAEEA EEEWERRNKV LNHFSIMQQR
       190        200        210        220        230        240
RLKDQDQDED EEEKEKRSRK KPSELRIHDL EDDLEMSSDA SDASGEEGSR TSKAKKKAPV
       250        260        270        280        290        300
TKAGRKKKKK KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SPDETEGKPK VPQQEDGPKG
       310        320        330        340        350        360
VDEQSESSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSDDSDSSEE SDIDSETSSA
       370        380        390        400        410        420
LFMAKKKTPP KRERKPSGGS SKGTSRPGTP SAEAASTSST LRAAASKLEQ GKRTSETPAA
       430        440        450        460        470        480
KRLRMDTGPQ SLSGKSTPSS GDVQVTEDAV RRYLTRKPMT TKDLLKKFQT KKTGLSSEQT
       490        500
VNVLAQILKR LNPERKMIGD KMHFSLKE   

Encoded by Gtf2f1 gene

FULL NAME: general transcription factor IIF, polypeptide 1


OTHER NAME(S):
2810405L04Rik
C76800
RAP74


Nucleic acid sequence

        10         20         30         40         50         60
atggcggctc taggctccag cagccagaat gtcaccgagt acgtcgtccg agtccccaag
        70         80         90        100        110        120
aacacagcca aaagatacaa cataatggct tttaatgcag ccgataaagt caactttgct
       130        140        150        160        170        180
acctggaacc aggcacggct ggagcgagat ctgagcaaca agaagattta ccaggaagaa
       190        200        210        220        230        240
gagatgccag agtccggtgc aggcagtgaa ttcaaccgca agcttaggga ggaggcgcgc
       250        260        270        280        290        300
cggaagaagt atggcattgt cctaaaggag tttcggcctg aggaccagcc ttggctactc
       310        320        330        340        350        360
cgtgtcaatg gcaaatcagg acggaagttc aaaggcatta agaaaggcgg ggtaacagag
       370        380        390        400        410        420
aacacagcct actacatctt cacacagtgt gctgatggtg cctttgaggc tttccctgta
       430        440        450        460        470        480
cagaactggt acaatttcac accactggcc cgacaccgca cactcactgc tgaggaagcc
       490        500        510        520        530        540
gaggaggaat gggagaggag gaacaaggtc ctaaaccact tcagcatcat gcagcagcgg
       550        560        570        580        590        600
cggctcaagg accaggacca ggatgaagat gaggaggaga aggagaagcg cagtcgcaag
       610        620        630        640        650        660
aagcctagtg agctgcgcat tcatgacctg gaggatgacc tggaaatgtc ctccgatgcc
       670        680        690        700        710        720
agcgatgcca gtggtgaaga gggcagcaga acctccaagg ctaagaaaaa ggcccctgtg
       730        740        750        760        770        780
accaaggcag gcaggaagaa gaaaaagaag aagggctcag atgatgaggc ttttgaggac
       790        800        810        820        830        840
agcgatgatg gggacttcga gggccaggag gtagactaca tgtctgatgg ctccagcagc
       850        860        870        880        890        900
tctccagatg agacagaagg caagcccaaa gtgccccagc aggaggatgg cccaaagggg
       910        920        930        940        950        960
gtggatgagc agagcgagag cagtgaggag agtgaggagg agaagccccc cgaggaggac
       970        980        990       1000       1010       1020
aaggaggagg aagaagagaa gaaggcccct accccacaag agaagaagcg caggaaagac
      1030       1040       1050       1060       1070       1080
agcagtgatg actcagacag ctcagaagag agcgacattg acagtgagac ctcctctgca
      1090       1100       1110       1120       1130       1140
ctcttcatgg cgaagaagaa gacaccccca aagagggagc ggaagccatc gggggggagt
      1150       1160       1170       1180       1190       1200
tcaaagggca ccagtcggcc agggactccc agtgcagaag cagcaagcac ctcttctacc
      1210       1220       1230       1240       1250       1260
ctgcgggctg cagccagcaa gctggagcag gggaagcgga cgagtgagac tccagcagcc
      1270       1280       1290       1300       1310       1320
aagcgtcttc ggatggacac gggtccccag agcctgtctg ggaagtccac acccagcagc
      1330       1340       1350       1360       1370       1380
ggtgatgtcc aggtgacaga ggacgctgtg cgccgctacc tgacccgcaa gcccatgacc
      1390       1400       1410       1420       1430       1440
acaaaggacc tgctgaagaa gttccagacc aagaagacag ggctgagcag cgagcagaca
      1450       1460       1470       1480       1490       1500
gtaaatgtgc tggcgcagat cctcaagcgc ctcaaccctg agcgcaagat gattggtgat
      1510       1520
aagatgcact tctccctcaa agagtga   

Last modification date: Oct. 2, 2011