Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: General transcription factor IIF subunit 1


DESCRIPTION:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

STRUCTURE SIMILARITY:
Belongs to the TFIIF alpha subunit family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases (By similarity).


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSSASKSTPS AASGSSTSAA AAAAASVASG SASSSANVQE FKIRVPKMPK KHHVMRFNAT
        70         80         90        100        110        120
LNVDFAQWRN VKLERENNMK EFRGMEEDQP KFGAGSEYNR DQREEARRKK FGIIARKYRP
       130        140        150        160        170        180
EAQPWILKVG GKTGKKFKGI REGGVGENAA FYVFTHAPDG AIEAYPLTEW YNFQPIQRYK
       190        200        210        220        230        240
SLSAEEAEQE FGRRKKVMNY FSLMLRKRLR GDEEEEQDPE EAKLIKAATK KSKELKITDM
       250        260        270        280        290        300
DEWIDSEDES DSEDEEDKKK KEQEDSDDGK AKGKGKKGAD KKKKKRDVDD EAFEESDDGD
       310        320        330        340        350        360
EEGREMDYDT SSSEDEPDPE AKVDKDMKGV AEEDALRKLL TSDEEEDDEK KSDESDKEDA
       370        380        390        400        410        420
DGEKKKKDKG KDEVSKDKKK KKPTKDDKKG KSNGSGDSST DFSSDSTDSE DDLSNGPPKK
       430        440        450        460        470        480
KVVVKDKDKE KEKEKESAAS SKVIASSSNA NKSRSATPTL STDASKRKMN SLPSDLTASD
       490        500        510        520        530        540
TSNSPTSTPA KRPKNEISTS LPTSFSGGKV EDYGITEEAV RRYLKRKPLT ATELLTKFKN
       550        560        570
KKTPVSSDRL VETMTKILKK INPVKHTIQG KMYLWIK  

Encoded by TfIIFalpha gene

FULL NAME: Transcription factor IIFalpha


OTHER NAME(S):
154355_at
CG10281
Dmel\CG10281
DmTFIIF
F5a
RAP74
TfIIF
TFIIF
TFIIF-L
TFIIFalpha


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgagcg cgtcaaagtc gacgccgagc gctgccagcg ggagctccac gtccgcagct
        70         80         90        100        110        120
gccgccgccg cagcctctgt cgcctcagga tccgcctcgt catccgccaa cgtgcaggag
       130        140        150        160        170        180
ttcaagatcc gcgtgcccaa gatgcccaag aagcaccatg tgatgcggtt caacgccacg
       190        200        210        220        230        240
ctcaatgtgg atttcgcgca gtggagaaat gtgaaactgg agcgggaaaa caacatgaag
       250        260        270        280        290        300
gagttccggg gcatggagga ggatcagccc aagtttggtg ctggatcgga gtacaaccgg
       310        320        330        340        350        360
gatcagcgcg aggaggcgcg ccgcaagaag tttggcatta tagcgagaaa gtaccgtcca
       370        380        390        400        410        420
gaggcacagc catggatcct taaagtgggt ggcaagactg gaaagaagtt caaaggcatc
       430        440        450        460        470        480
cgcgagggcg gcgtaggcga gaatgcagct ttctatgtgt tcacccatgc accagacggc
       490        500        510        520        530        540
gccattgagg catacccctt gaccgagtgg tacaacttcc agcctattca gcgctacaaa
       550        560        570        580        590        600
tcgctgtcgg cggaggaggc cgaacaggaa tttggtcggc gcaaaaaggt gatgaactac
       610        620        630        640        650        660
ttctccctta tgttgcgaaa gcgtctgcgc ggcgatgagg aagaggagca ggatccggag
       670        680        690        700        710        720
gaggctaagc taattaaggc agccaccaaa aaatccaagg agctcaagat cactgacatg
       730        740        750        760        770        780
gatgaatgga ttgattccga ggatgagtcg gattcggagg acgaggagga taaaaagaag
       790        800        810        820        830        840
aaggagcagg aagacagcga cgatggcaag gccaagggaa agggcaagaa gggcgcagac
       850        860        870        880        890        900
aagaaaaaga aaaagaggga tgttgatgac gaggccttcg aggagtcgga cgatggtgac
       910        920        930        940        950        960
gaggagggca gagaaatgga ctacgacacc agctccagtg aagacgaacc agatccagag
       970        980        990       1000       1010       1020
gcaaaggtgg acaaggacat gaaaggcgtg gccgaggaag atgcgctccg caagctgctt
      1030       1040       1050       1060       1070       1080
acctccgatg aagaggagga tgatgagaag aagtctgatg agtcggacaa ggaggatgcc
      1090       1100       1110       1120       1130       1140
gacggcgaga aaaaaaagaa ggataagggc aaggacgagg tatccaagga caaaaagaag
      1150       1160       1170       1180       1190       1200
aagaaaccca caaaggacga caagaagggc aagtcgaatg gcagcggtga ctcgtccaca
      1210       1220       1230       1240       1250       1260
gacttcagct ctgacagcac agactccgag gacgacctta gcaacggacc gcccaagaag
      1270       1280       1290       1300       1310       1320
aaggtcgtcg tcaaggacaa agacaaggaa aaggaaaagg agaaagagag cgctgcgagc
      1330       1340       1350       1360       1370       1380
agcaaggtca tcgccagcag cagcaatgcc aataaatctc gctcggccac tccaacgctc
      1390       1400       1410       1420       1430       1440
tcgacggatg ccagcaagcg caagatgaac agcttaccca gcgatctcac cgcttcggac
      1450       1460       1470       1480       1490       1500
acaagcaaca gtcccaccag cacgccagca aagaggccta agaacgagat tagcacatcg
      1510       1520       1530       1540       1550       1560
ctgcccactt ccttctctgg cggcaaagta gaggactacg gcatcaccga ggaggcggtg
      1570       1580       1590       1600       1610       1620
cgtcggtatc ttaagcgaaa gcccctgacc gccaccgagt tgctcaccaa gttcaagaac
      1630       1640       1650       1660       1670       1680
aagaagacgc ctgtctccag cgaccgtttg gtcgagacca tgacgaaaat cctgaagaag
      1690       1700       1710       1720       1730
atcaatcccg tcaagcacac catccagggg aaaatgtatc tctggatcaa gtag

Last modification date: Oct. 2, 2011