Homo sapiens L. (human) [HSA]

FULL NAME: General transcription factor IIF subunit 1


DESCRIPTION:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

STRUCTURE SIMILARITY:
Belongs to the TFIIF alpha subunit family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MAALGPSSQN VTEYVVRVPK NTTKKYNIMA FNAADKVNFA TWNQARLERD LSNKKIYQEE
        70         80         90        100        110        120
EMPESGAGSE FNRKLREEAR RKKYGIVLKE FRPEDQPWLL RVNGKSGRKF KGIKKGGVTE
       130        140        150        160        170        180
NTSYYIFTQC PDGAFEAFPV HNWYNFTPLA RHRTLTAEEA EEEWERRNKV LNHFSIMQQR
       190        200        210        220        230        240
RLKDQDQDED EEEKEKRGRR KASELRIHDL EDDLEMSSDA SDASGEEGGR VPKAKKKAPL
       250        260        270        280        290        300
AKGGRKKKKK KGSDDEAFED SDDGDFEGQE VDYMSDGSSS SQEEPESKAK APQQEEGPKG
       310        320        330        340        350        360
VDEQSDSSEE SEEEKPPEED KEEEEEKKAP TPQEKKRRKD SSEESDSSEE SDIDSEASSA
       370        380        390        400        410        420
LFMAKKKTPP KRERKPSGGS SRGNSRPGTP SAEGGSTSST LRAAASKLEQ GKRVSEMPAA
       430        440        450        460        470        480
KRLRLDTGPQ SLSGKSTPQP PSGKTTPNSG DVQVTEDAVR RYLTRKPMTT KDLLKKFQTK
       490        500        510
KTGLSSEQTV NVLAQILKRL NPERKMINDK MHFSLKE  

Encoded by GTF2F1 gene

FULL NAME: general transcription factor IIF, polypeptide 1, 74kDa


OTHER NAME(S):
BTF4
RAP74
TF2F1
TFIIF


Nucleic acid sequence

        10         20         30         40         50         60
atggcggccc taggccctag cagccagaat gtcactgaat acgtcgttcg agttcctaag
        70         80         90        100        110        120
aatacaacca aaaaatataa catcatggct tttaatgcag ccgacaaagt caactttgct
       130        140        150        160        170        180
acgtggaatc aggctcggct ggagcgggac ttgagcaaca agaaaatcta ccaagaggag
       190        200        210        220        230        240
gagatgcccg aatcgggcgc gggcagtgag ttcaaccgca agcttcggga ggaggctcgg
       250        260        270        280        290        300
aggaagaagt acggcatcgt cctcaaggag ttccggcccg aggaccagcc ctggctgctc
       310        320        330        340        350        360
cgggtcaacg gcaaatcagg caggaagttc aagggcatca agaagggagg cgtaacagag
       370        380        390        400        410        420
aacacgtcct actacatctt cacccagtgc cccgacgggg ccttcgaggc cttccccgtg
       430        440        450        460        470        480
cacaactggt acaatttcac accgctggcc cggcatcgca cgctcactgc cgaggaggcc
       490        500        510        520        530        540
gaggaggagt gggagaggag gaacaaggtg ctgaaccact tcagcatcat gcagcagcgg
       550        560        570        580        590        600
cggctcaagg atcaggacca ggacgaggat gaggaggaga aggagaaacg tggccgcagg
       610        620        630        640        650        660
aaggcgagcg agctgcgcat ccacgacctg gaggacgacc tggagatgtc gtccgatgcc
       670        680        690        700        710        720
agtgatgcca gtggtgagga ggggggcaga gtccccaagg ccaagaagaa ggcgccgctg
       730        740        750        760        770        780
gccaagggcg gcaggaaaaa gaagaagaag aagggttcag acgacgaggc cttcgaggac
       790        800        810        820        830        840
agcgatgatg gggacttcga gggccaagag gtggactaca tgtcagacgg ctccagtagc
       850        860        870        880        890        900
tcccaagaag agcctgagag caaggccaag gcgccgcagc aggaggaggg gcccaagggt
       910        920        930        940        950        960
gtcgatgagc agagcgacag tagtgaggag agtgaggagg agaagccgcc tgaggaggac
       970        980        990       1000       1010       1020
aaggaggagg aggaggagaa gaaggcaccc accccgcagg agaagaagcg caggaaagac
      1030       1040       1050       1060       1070       1080
agcagcgagg agtcggacag ctcagaggag agcgacattg acagcgaggc ctcctcagcc
      1090       1100       1110       1120       1130       1140
ctcttcatgg cgaagaagaa gacgccaccc aagagagagc ggaagccgtc gggagggagc
      1150       1160       1170       1180       1190       1200
tcaaggggca acagccgccc aggcacgccc agcgcagagg gtggcagcac ctcctccacc
      1210       1220       1230       1240       1250       1260
ctgcgggcgg ctgccagcaa actcgagcaa gggaagcggg tgagcgagat gcctgcagcc
      1270       1280       1290       1300       1310       1320
aagcggttgc ggctggacac gggaccccag agcctgtctg ggaagtcgac accccagcca
      1330       1340       1350       1360       1370       1380
ccatcaggca agacaacacc caacagcggc gacgtgcagg tgactgagga tgccgtgcgc
      1390       1400       1410       1420       1430       1440
cgctacctga cacggaagcc catgaccact aaggacctgc tgaaaaagtt ccagaccaag
      1450       1460       1470       1480       1490       1500
aagacagggc tgagcagcga gcagacagtg aacgtgttgg cccagatcct caagcgactc
      1510       1520       1530       1540       1550
aaccccgagc gcaagatgat caacgacaaa atgcacttct ccctcaagga gtga

Last modification date: Oct. 2, 2011