Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: Transcription initiation factor IIF subunit alpha


DESCRIPTION:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II. Its functions include the recruitment of RNA polymerase II to the promoter bound DNA-TBP-TFIIB complex, decreasing the affinity of RNA polymerase II for non-specific DNA, allowing for the subsequent recruitment of TFIIE and TFIIH, and facilitating RNA polymerase II elongation.

MISCELLANEOUS:
Present with 1920 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the TFIIF alpha subunit family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases (By similarity).


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSRRNPPGSR NGGGPTNASP FIKRDRMRRN FLRMRMGQNG SNSSSPGVPN GDNSRGSLVK
        70         80         90        100        110        120
KDDPEYAEER EKMLLQIGVE ADAGRSNVKV KDEDPNEYNE FPLRAIPKED LENMRTHLLK
       130        140        150        160        170        180
FQSKKKINPV TDFHLPVRLH RKDTRNLQFQ LTRAEIVQRQ KEISEYKKKA EQERSTPNSG
       190        200        210        220        230        240
GMNKSGTVSL NNTVKDGSQT PTVDSVTKDN TANGVNSSIP TVTGSSVPPA SPTTVSAVES
       250        260        270        280        290        300
NGLSNGSTSA ANGLDGNAST ANLANGRPLV TKLEDAGPAE DPTKVGMVKY DGKEVTNEPE
       310        320        330        340        350        360
FEEGTMDPLA DVAPDGGGRA KRGNLRRKTR QLKVLDENAK KLRFEEFYPW VMEDFDGYNT
       370        380        390        400        410        420
WVGSYEAGNS DSYVLLSVED DGSFTMIPAD KVYKFTARNK YATLTIDEAE KRMDKKSGEV
       430        440        450        460        470        480
PRWLMKHLDN IGTTTTRYDR TRRKLKAVAD QQAMDEDDRD DNSEVELDYD EEFADDEEAP
       490        500        510        520        530        540
IIDGNEQENK ESEQRIKKEM LQANAMGLRD EEAPSENEED ELFGEKKIDE DGERIKKALQ
       550        560        570        580        590        600
KTELAALYSS DENEINPYLS ESDIENKENE SPVKKEEDSD TLSKSKRSSP KKQQKKATNA
       610        620        630        640        650        660
HVHKEPTLRV KSIKNCVIIL KGDKKILKSF PEGEWNPQTT KAVDSSNNAS NTVPSPIKQE
       670        680        690        700        710        720
EGLNSTVAER EETPAPTITE KDIIEAIGDG KVNIKEFGKF IRRKYPGAEN KKLMFAIVKK
       730
LCRKVGNDHM ELKKE    

Encoded by TFG1 gene


OTHER NAME(S):
RAP74
SSU71


Nucleic acid sequence

        10         20         30         40         50         60
atgtccagac gcaatccacc aggcagtaga aacgggggag gtccgacgaa tgcctctccc
        70         80         90        100        110        120
ttcattaaaa gagacagaat gagaagaaat ttcctgagga tgagaatggg tcaaaacggc
       130        140        150        160        170        180
agcaattcta gttccccagg cgtaccaaat ggagacaaca gcaggggatc tcttgtcaaa
       190        200        210        220        230        240
aaggatgatc ctgagtatgc tgaagagaga gagaaaatgc ttttgcaaat cggtgtcgag
       250        260        270        280        290        300
gccgatgctg gcaggagcaa tgttaaagta aaggacgaag atcctaatga atataatgaa
       310        320        330        340        350        360
tttcccttaa gagctattcc aaaggaggat ttagaaaaca tgaggacaca tcttttgaag
       370        380        390        400        410        420
tttcagagta aaaaaaagat aaaccctgta acagacttcc atcttcccgt aagactgcat
       430        440        450        460        470        480
aggaaggata cgagaaactt gcagtttcag ctaacaagag cagaaattgt tcaaaggcaa
       490        500        510        520        530        540
aaagaaattt ctgagtataa aaaaaaagca gagcaagaaa gaagtactcc taactcgggt
       550        560        570        580        590        600
ggtatgaata aatcaggaac ggtctcgctc aataatactg ttaaagatgg gtctcagaca
       610        620        630        640        650        660
cctactgttg attcagttac taaagacaac acggccaacg gtgtgaactc ctccattcct
       670        680        690        700        710        720
actgtaactg gctcttctgt ccctcctgct agtcctacta ctgtatccgc cgttgaaagt
       730        740        750        760        770        780
aatggactgt caaatggttc aactagtgca gctaacggtt tggatggcaa tgcatctaca
       790        800        810        820        830        840
gcgaatctag ctaacggaag gccgttagtg acaaaactag aggatgcagg cccagctgaa
       850        860        870        880        890        900
gaccctacta aagttggaat ggtcaagtac gacggaaaag aagtgactaa cgaaccggaa
       910        920        930        940        950        960
tttgaagaag gaactatgga tccactagca gatgtggcac cagatggagg cggtagggcc
       970        980        990       1000       1010       1020
aaacgaggaa atttgagaag gaaaactcgt caattaaaag ttcttgatga gaacgccaaa
      1030       1040       1050       1060       1070       1080
aagctgagat ttgaggaatt ttatccatgg gttatggaag attttgatgg gtacaataca
      1090       1100       1110       1120       1130       1140
tgggtgggtt cttatgaagc aggtaactca gattcttatg tcttgttaag tgtagaagat
      1150       1160       1170       1180       1190       1200
gatggaagtt ttaccatgat tcctgctgat aaggtttata agtttaccgc aagaaataaa
      1210       1220       1230       1240       1250       1260
tatgctactt tgaccattga cgaagcagaa aaaagaatgg acaaaaaaag tggtgaagtg
      1270       1280       1290       1300       1310       1320
ccacgttggt tgatgaagca tttggataat ataggtacaa ctacaactag atatgacaga
      1330       1340       1350       1360       1370       1380
acaagaagaa agcttaaagc cgtcgctgat caacaagcta tggatgaaga tgatcgtgat
      1390       1400       1410       1420       1430       1440
gacaattcag aagtagagtt agattatgat gaagagtttg ccgatgatga ggaggcacct
      1450       1460       1470       1480       1490       1500
attatagatg gtaatgaaca agaaaataaa gaatcagaac aaagaatcaa gaaggagatg
      1510       1520       1530       1540       1550       1560
ctgcaagcta atgcgatggg gcttcgtgat gaagaagctc cttccgaaaa cgaagaagat
      1570       1580       1590       1600       1610       1620
gagttatttg gggaaaagaa gattgatgag gatggtgaaa gaattaagaa ggcattacaa
      1630       1640       1650       1660       1670       1680
aagacagaac ttgcagcact atactcatcg gatgaaaatg agatcaaccc atacttatct
      1690       1700       1710       1720       1730       1740
gaatccgata ttgaaaacaa agagaatgaa tcgcccgtta aaaaggaaga agattcggac
      1750       1760       1770       1780       1790       1800
actctatcca aatccaagag atcttctcca aagaaacagc aaaagaaagc tacaaatgcg
      1810       1820       1830       1840       1850       1860
catgtgcata aagagccaac tttgagggtg aaaagtatta aaaactgtgt cattatcttg
      1870       1880       1890       1900       1910       1920
aagggggata agaaaatact gaaaagcttc ccagagggag aatggaatcc acagacgaca
      1930       1940       1950       1960       1970       1980
aaagctgtag atagtagtaa taatgcatcg aatacagtgc cttcgccaat caaacaagag
      1990       2000       2010       2020       2030       2040
gaaggcttga attctacagt ggcagaaagg gaagaaactc cagcgcctac aataacagaa
      2050       2060       2070       2080       2090       2100
aaagatatca tcgaggctat tggtgatggc aaagtcaata tcaaagagtt tggaaagttc
      2110       2120       2130       2140       2150       2160
atcagaagaa aatatcctgg cgcagagaat aaaaagctaa tgtttgccat tgtaaaaaaa
      2170       2180       2190       2200
ttgtgtcgaa aggttggcaa tgaccacatg gaattaaaga aagagtag 

Last modification date: Oct. 2, 2011