Homo sapiens L. (human) [HSA]

FULL NAME: General transcription factor IIE subunit 1


DESCRIPTION:
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

STRUCTURE SIMILARITY:
Contains 1 HTH TFE/IIEalpha-type domain.
Belongs to the TFIIE alpha subunit family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR
        70         80         90        100        110        120
SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD
       130        140        150        160        170        180
STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF
       190        200        210        220        230        240
NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA
       250        260        270        280        290        300
TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI
       310        320        330        340        350        360
DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE
       370        380        390        400        410        420
SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP
       430
EEKEAYIAMG QRMFEDLFE    

Encoded by GTF2E1 gene

FULL NAME: general transcription factor IIE, polypeptide 1, alpha 56kDa


OTHER NAME(S):
FE
TF2E1
TFIIE-A


Nucleic acid sequence

        10         20         30         40         50         60
atggcagacc cagatgtcct cactgaagtt ccagcagcat tgaagcggtt agccaagtat
        70         80         90        100        110        120
gtgatccggg gattttatgg cattgagcat gccttggcct tggacatctt gatcaggaac
       130        140        150        160        170        180
tcctgtgtga aagaggagga tatgctggag ctgctcaagt ttgatcggaa gcaacttcga
       190        200        210        220        230        240
tcagttttga ataatttaaa gggagacaag tttatcaaat gcagaatgag ggtagagact
       250        260        270        280        290        300
gctgcagacg ggaaaaccac tcgccataac tactacttca tcaattatcg tactcttgtt
       310        320        330        340        350        360
aatgtggtaa aatataaact ggaccacatg agaagaagaa ttgagaccga tgagagagat
       370        380        390        400        410        420
tcgaccaacc gggcttcctt caaatgtcct gtctgtagta gtactttcac agacttagaa
       430        440        450        460        470        480
gctaatcagc tctttgatcc tatgacagga actttccgct gtactttttg ccatacagag
       490        500        510        520        530        540
gtagaagagg atgaatcagc aatgcccaaa aaagatgcac gcacactttt ggcaaggttt
       550        560        570        580        590        600
aatgaacaaa ttgagcccat ttatgcattg cttcgggaga cagaggatgt gaacttggcc
       610        620        630        640        650        660
tatgaaatac ttgagccaga acccacagaa atcccagccc tgaaacagag caaggaccat
       670        680        690        700        710        720
gcagcaacta ctgctggagc tgctagccta gcaggtgggc accaccggga agcatgggcc
       730        740        750        760        770        780
accaaaggtc cttcctatga agacttatac actcagaatg ttgtcattaa catggatgac
       790        800        810        820        830        840
caagaagatc ttcatcgagc ctcactggaa gggaaatctg ccaaagagag gcctatttgg
       850        860        870        880        890        900
ttgagagaaa gcactgtcca aggggcatat ggttctgaag atatgaaaga agggggcata
       910        920        930        940        950        960
gatatggacg catttcagga gcgtgaggaa ggccatgctg ggcctgatga caacgaagag
       970        980        990       1000       1010       1020
gtcatgcgag cactgctcat tcacgagaaa aagacttcct ctgccatggc tggttcagtg
      1030       1040       1050       1060       1070       1080
ggggcagctg ctccagtgac cgctgccaat ggcagtgact cagaaagcga gaccagtgag
      1090       1100       1110       1120       1130       1140
tcagatgatg attctccacc ccgtccggca gctgtggctg tgcataaacg agaagaggat
      1150       1160       1170       1180       1190       1200
gaagaggaag atgacgagtt tgaagaagta gcagatgacc ccattgtcat ggtggctggc
      1210       1220       1230       1240       1250       1260
cgtccgttct cctacagtga agtgagccaa cggccagagc tagtggccca gatgacacca
      1270       1280       1290       1300       1310       1320
gaagaaaagg aagcatatat agcaatggga caacgcatgt ttgaggacct ctttgagtga

Last modification date: Oct. 2, 2011