Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor TFIID subunit 11


DESCRIPTION:
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

STRUCTURE SIMILARITY:
Belongs to the TAF11 family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MDDAHESPSD KGGETGESDE TAAVPGDPGA TDTDGIPEET DGDADVDLKE AAAEEGELES
        70         80         90        100        110        120
QDVSDLTTVE REDSSLLNPA AKKLKIDTKE KKEKKQKVDE DEIQKMQILV SSFSEEQLNR
       130        140        150        160        170        180
YEMYRRSAFP KAAIKRLIQS ITGTSVSQNV VIAMSGISKV FVGEVVEEAL DVCEKWGEMP
       190        200        210
PLQPKHMREA VRRLKSKGQI PNSKHKKIIF F  

Encoded by TAF11 gene

FULL NAME: TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa


OTHER NAME(S):
MGC:15243
TAF2I
TAFII28
PRO2134


DESCRIPTION:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggacgatg cccacgagtc gccctccgac aaaggtggag agacagggga gtcggatgag
        70         80         90        100        110        120
acggccgctg tgcccgggga cccgggggct accgacaccg atggaatccc agaggaaact
       130        140        150        160        170        180
gacggagacg cagatgtgga cttgaaagaa gctgcagcgg aggaaggcga gctcgagagt
       190        200        210        220        230        240
caggatgtct cagatttaac aacagttgaa agggaagact catcattact taatcctgca
       250        260        270        280        290        300
gccaaaaaac tgaaaataga taccaaagaa aagaaagaga aaaagcagaa agtagatgaa
       310        320        330        340        350        360
gatgagattc agaagatgca aatcctggtt tcttcttttt ctgaggagca gctgaaccgt
       370        380        390        400        410        420
tatgaaatgt atcgccgctc agctttccct aaggcagcca tcaaaaggct gatccagtcc
       430        440        450        460        470        480
atcactggca cctctgtgtc tcagaatgtt gttattgcta tgtctggtat ttccaaggtt
       490        500        510        520        530        540
ttcgtcgggg aggtggtaga agaagcactg gatgtgtgtg agaagtgggg agaaatgcca
       550        560        570        580        590        600
ccactacaac ccaaacatat gagggaagcc gttagaaggt taaagtcaaa aggacagatc
       610        620        630
cctaactcga agcacaaaaa aatcatcttc ttctag  

Last modification date: Oct. 2, 2011