Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: Transcription initiation factor TFIID subunit 9


DESCRIPTION:
Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complex SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3, and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.

MISCELLANEOUS:
Present with 7000 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Contains 1 histone-fold domain.
Belongs to the TAF9 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MNGGGKNVLN KNSVGSVSEV GPDSTQEETP RDVRLLHLLL ASQSIHQYED QVPLQLMDFA
        70         80         90        100        110        120
HRYTQGVLKD ALVYNDYAGS GNSAGSGLGV EDIRLAIAAR TQYQFKPTAP KELMLQLAAE
       130        140        150
RNKKALPQVM GTWGVRLPPE KYCLTAKEWD LEDPKSM  

Encoded by TAF9 gene


OTHER NAME(S):
TAF17


Nucleic acid sequence

        10         20         30         40         50         60
atgaacggcg gaggcaagaa tgttttgaat aaaaactcag tgggctcagt atcagaagtt
        70         80         90        100        110        120
ggtccggact caacacaaga ggaaacgcca cgagatgtcc gtcttttgca tctgctcctc
       130        140        150        160        170        180
gcatcacagt cgattcatca atatgaggac caagtaccgc tacaattgat ggattttgca
       190        200        210        220        230        240
cataggtaca cacaaggagt ccttaaggac gcgttggttt acaacgacta cgctggcagt
       250        260        270        280        290        300
ggaaattctg ccggcagtgg attaggagta gaagacatac ggcttgccat tgcagcgaga
       310        320        330        340        350        360
acacaatacc aatttaagcc tacggcacct aaggagctca tgttacagtt agctgcggaa
       370        380        390        400        410        420
agaaacaaga aggcattacc tcaagtgatg ggtacgtggg gtgtcaggct tcccccagaa
       430        440        450        460        470
aaatattgtc tcacagcgaa ggagtgggac cttgaggacc caaagtctat gtga

Last modification date: Oct. 2, 2011