Mus musculus L. (mouse) [MMU]

FULL NAME: General transcription factor IIH subunit 5


DESCRIPTION:
Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell (By similarity).

STRUCTURE SIMILARITY:
Belongs to the TFB5 family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MVNVLKGVLI ECDPAMKQFL LYLDEANALG KKFIIQDIDD THVFVIAELV NVLQERVGEL
        70
MDQNAFSLTQ K    

Encoded by Gtf2h5 gene

FULL NAME: general transcription factor IIH, polypeptide 5


OTHER NAME(S):
2700017P07Rik
2810432H05Rik
D17Wsu155e


Nucleic acid sequence

        10         20         30         40         50         60
atggtcaacg tgctgaaagg ggtgcttata gaatgtgacc ctgccatgaa gcagttcttg
        70         80         90        100        110        120
ctgtacttgg atgaggccaa cgccttgggg aagaagttca tcattcagga cattgatgac
       130        140        150        160        170        180
acgcacgtct tcgtcattgc cgagctggtc aacgtcctcc aggagcgagt aggggaactg
       190        200        210
atggaccaga atgccttttc tcttacccag aagtga  

Last modification date: Oct. 2, 2011