Homo sapiens L. (human) [HSA]


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MTKRRLQTIT ACLQLREGSP SLHRGLHPSR EEKRDSRMAE EKKLKLSNTV LPSESMKVVA
        70         80         90        100        110        120
ESMGIAQIQE ETCQLLTDEV SYRIKEIAQD ALKFMHMGKR QKLTTSDIDY ALKLKNVEPL
       130        140        150        160        170        180
YGFHAQEFIP FRFASGGGRE LYFYEEKEVD LSDIINTPLP RVPLDVCLKA HWLSIEGCQP
       190        200        210        220        230        240
AIPENPPPAP KEQQKAEATE PLKSAKPGQE EDGPLKGKGQ GATTADGKGK EKKAPPLLEG
       250        260        270        280        290        300
APLRLKPRSI HELSVEQQLY YKEITEACVG SCEAKRAEAL QSIATDPGLY QMLPRFSTFI
       310        320        330        340        350        360
SEGVRVNVVQ NNLALLIYLM RMVKALMDNP TLYLEKYVHE LIPAVMTCIV SRQLCLRPDV
       370        380        390        400        410        420
DNHWALRDFA ARLVAQICKH FSTTTNNIQS RITKTFTKSW VDEKTPWTTR YGSIAGLAEL
       430        440        450        460        470        480
GHDVIKTLIL PRLQQEGERI RSVLDGPVLS NIDRIGADHV QSLLLKHCAP VLAKLRPPPD
       490        500        510        520        530        540
NQDAYRAEFG SLGPLLCSQV VKARAQAALQ AQQVNRTTLT ITQPRPTLTL SQAPQPGPRT
       550        560        570        580        590        600
PGLLKVPGSI ALPVQTLVSA RAAAPPQPSP PPTKFIVMSS SSSAPSTQQV LSLSTSAPGS
       610        620        630        640        650        660
GSTTTSPVTT TVPSVQPIVK LVSTATTAPP STAPSGPGSV QKYIVVSLPP TGEGKGGPTS
       670        680        690        700        710
HPSPVPPPAS SPSPLSGSAL CGGKQEAGDS PPPAPGTPKA NGSQPNSGSP QPAP

Encoded by TAF6 gene

FULL NAME: TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa


OTHER NAME(S):
DKFZp781E21155
MGC:8964
TAF(II)70
TAF(II)80
TAF2E
TAFII-70
TAFII-80
TAFII70
TAFII80
TAFII85


DESCRIPTION:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgacaaagc gccgtctaca aacaatcacc gcttgccttc aacttcggga agggtctccg
        70         80         90        100        110        120
tctctccacc gggggcttca tccttccagg gaggagaaga gggactccag aatggctgag
       130        140        150        160        170        180
gagaagaagc tgaagcttag caacactgtg ctgccctcgg agtccatgaa ggtggtggct
       190        200        210        220        230        240
gaatccatgg gcatcgccca gattcaggag gagacctgcc agctgctaac ggatgaggtc
       250        260        270        280        290        300
agctaccgca tcaaagagat cgcacaggat gccttgaagt tcatgcacat ggggaagcgg
       310        320        330        340        350        360
cagaagctca ccaccagtga cattgactac gccttgaagc taaagaatgt cgagccactc
       370        380        390        400        410        420
tatggcttcc acgcccagga gttcattcct ttccgcttcg cctctggtgg gggccgggag
       430        440        450        460        470        480
ctttacttct atgaggagaa ggaggttgat ctgagcgaca tcatcaatac ccctctgccc
       490        500        510        520        530        540
cgggtgcccc tggacgtctg cctcaaagct cattggctga gcatcgaggg ctgccagcca
       550        560        570        580        590        600
gctatccccg agaacccgcc cccagctccc aaagagcaac agaaggctga agccacagaa
       610        620        630        640        650        660
cccctgaagt cagccaagcc aggccaggag gaagacggac ccctgaaggg caaaggtcaa
       670        680        690        700        710        720
ggggccacca cagccgacgg caaagggaaa gagaagaagg cgccgccctt gctggagggg
       730        740        750        760        770        780
gcccccttgc gactgaagcc ccggagcatc cacgagttgt ctgtggagca gcagctctac
       790        800        810        820        830        840
tacaaggaga tcaccgaggc ctgcgtgggc tcctgcgagg ccaagagggc ggaagccctg
       850        860        870        880        890        900
caaagcattg ccacggaccc tggactgtat cagatgctgc cacggttcag tacctttatc
       910        920        930        940        950        960
tcggaggggg tccgtgtgaa cgtggttcag aacaacctgg ccctactcat ctacctgatg
       970        980        990       1000       1010       1020
cgtatggtga aagcgctgat ggacaacccc acgctctatc tagaaaaata cgtccatgag
      1030       1040       1050       1060       1070       1080
ctgattccag ctgtgatgac ctgcatcgtg agcagacagt tgtgcctgcg accagatgtg
      1090       1100       1110       1120       1130       1140
gacaatcact gggcactccg agactttgct gcccgcctgg tggcccagat ctgcaagcat
      1150       1160       1170       1180       1190       1200
tttagcacaa ccactaacaa catccagtcc cggatcacca agaccttcac caagagctgg
      1210       1220       1230       1240       1250       1260
gtggacgaga agacgccctg gacgactcgt tatggctcca tcgcaggctt ggctgagctg
      1270       1280       1290       1300       1310       1320
ggacacgatg ttatcaagac tctgattctg ccccggctgc agcaggaagg ggagcggatc
      1330       1340       1350       1360       1370       1380
cgcagtgtgc tggacggccc tgtgctgagc aacattgacc ggattggagc agaccatgtg
      1390       1400       1410       1420       1430       1440
cagagcctcc tgctgaaaca ctgtgctcct gttctggcaa agctgcgccc accgcctgac
      1450       1460       1470       1480       1490       1500
aatcaggacg cctatcgggc agaattcggg tcccttgggc ccctcctctg ctcccaggtg
      1510       1520       1530       1540       1550       1560
gtcaaggctc gggcccaggc tgctctgcag gctcagcagg tcaacaggac cactctgacc
      1570       1580       1590       1600       1610       1620
atcacgcagc cccggcccac gctgaccctc tcgcaggccc cacagcctgg ccctcgcacc
      1630       1640       1650       1660       1670       1680
cctggcttgc tgaaggttcc tggctccatc gcacttcctg tccagacact ggtgtctgca
      1690       1700       1710       1720       1730       1740
cgagcggctg ccccaccaca gccttcccct cctccaacca agtttattgt aatgtcatcg
      1750       1760       1770       1780       1790       1800
tcctccagcg ccccatccac ccagcaggtc ctgtccctca gcacctcggc ccccggctca
      1810       1820       1830       1840       1850       1860
ggttccacca ccacttcgcc cgtcaccacc accgtcccca gcgtgcagcc catcgtcaag
      1870       1880       1890       1900       1910       1920
ttggtctcca ccgccaccac cgcacccccc agcactgctc cctctggtcc tgggagtgtc
      1930       1940       1950       1960       1970       1980
cagaagtaca tcgtggtctc acttccccca acaggggagg gcaaaggagg ccccacctcc
      1990       2000       2010       2020       2030       2040
catccttctc cagttcctcc cccggcatcg tccccgtccc cactcagcgg cagtgccctt
      2050       2060       2070       2080       2090       2100
tgtgggggga agcaggaggc tggggacagt ccccctccag ctccagggac tccaaaagcc
      2110       2120       2130       2140
aatggctccc agcccaactc cggctcccct cagcctgctc cgtga 

Last modification date: Oct. 2, 2011