Homo sapiens L. (human) [HSA]


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSEREERRFV EIPRESVRLM AESTGLELSD EVAALLAEDV CYRLREATQN SSQFMKHTKR
        70         80         90        100        110        120
RKLTVEDFNR ALRWSSVEAV CGYGSQEALP MRPAREGELY FPEDREVNLV ELALATNIPK
       130        140        150        160        170        180
GCAETAVRVH VSYLDGKGNL APQGSVPSAV SSLTDDLLKY YHQVTRAVLG DDPQLMKVAL
       190        200        210        220        230        240
QDLQTNSKIG ALLPYFVYVV SGVKSVSHDL EQLHRLLQVA RSLFRNPHLC LGPYVRCLVG
       250        260        270        280        290        300
SVLYCVLEPL AASINPLNDH WTLRDGAALL LSHIFWTHGD LVSGLYQHIL LSLQKILADP
       310        320        330        340        350        360
VRPLCCHYGA VVGLHALGWK AVERVLYPHL STYWTNLQAV LDDYSVSNAQ VKADGHKVYG
       370        380        390        400        410        420
AILVAVERLL KMKAQAAEPN RGGPGGRGCR RLDDLPWDSL LFQESSSGGG AEPSFGSGLP
       430        440        450        460        470        480
LPPGGAGPED PSLSVTLADI YRELYAFFGD SLATRFGTGQ PAPTAPRPPG DKKEPAAAPD
       490        500        510        520        530        540
SVRKMPQLTA SAIVSPHGDE SPRGSGGGGP ASASGPAASE SRPLPRVHRA RGAPRQQGPG
       550        560        570        580        590        600
TGTRDVFQKS RFAPRGAPHF RFIIAGRQAG RRCRGRLFQT AFPAPYGPSP ASRYVQKLPM
       610        620
IGRTSRPARR WALSDYSLYL PL   

Encoded by TAF6L gene

FULL NAME: TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa


OTHER NAME(S):
FLJ11136
MGC4288
PAF65A


DESCRIPTION:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtcagagc gagaagagcg gcggtttgtg gagatccctc gggagtctgt ccggctcatg
        70         80         90        100        110        120
gcggagagca cgggcctgga gctgagcgat gaggtggcgg cgctgctcgc agaggacgtg
       130        140        150        160        170        180
tgctatcgtc tgagagaggc cacgcagaat agctctcagt tcatgaagca caccaaacgc
       190        200        210        220        230        240
cggaagctga cggttgagga cttcaacagg gccctcagat ggagcagcgt ggaggctgtg
       250        260        270        280        290        300
tgtggttacg gatcacagga ggcactgccc atgcgccccg ccagggaggg tgaactctac
       310        320        330        340        350        360
tttcctgagg atcgagaggt gaacctggtg gagctggccc tggctaccaa catccccaaa
       370        380        390        400        410        420
ggctgtgctg agacagctgt cagagttcat gtctcctacc tggatggcaa agggaacctg
       430        440        450        460        470        480
gcacctcaag gatcggtgcc cagtgctgtg tcttcactga cagatgacct tctcaagtac
       490        500        510        520        530        540
tatcaccagg tgactcgtgc tgtgctaggg gatgatccgc aactgatgaa ggttgcactc
       550        560        570        580        590        600
caggacttgc agacgaactc caagattggg gcactcctgc cttactttgt ttatgtggtc
       610        620        630        640        650        660
agtggggtga aatctgtaag ccatgacctg gagcaactgc accggctgct gcaggtggca
       670        680        690        700        710        720
cggagcctat ttcgtaatcc gcacctgtgc ttggggccct atgtccgctg tctggtgggc
       730        740        750        760        770        780
agtgtcctct actgtgtcct ggagccactg gctgcctcca tcaaccccct gaatgaccac
       790        800        810        820        830        840
tggactctgc gggatggggc tgccctcctg ctcagccaca tcttctggac tcatggggac
       850        860        870        880        890        900
cttgtaagtg gcctctatca gcatatcctg ctatccctgc agaagatcct ggcagatcct
       910        920        930        940        950        960
gtgcggccgc tctgctgcca ctatggagcc gtggtggggc tgcatgctct tggctggaag
       970        980        990       1000       1010       1020
gcagtagaac gagtcctgta cccacacctg tccacctact ggacaaactt gcaggctgtg
      1030       1040       1050       1060       1070       1080
ctggatgatt attcagtatc taatgcccag gtcaaagcag atggacacaa agtctatgga
      1090       1100       1110       1120       1130       1140
gccattctgg tggcggtaga gcgactgctg aagatgaagg cccaggcagc agagcccaac
      1150       1160       1170       1180       1190       1200
aggggtggcc caggtggcag ggggtgccgg cgcctggacg acctgccatg ggacagcctt
      1210       1220       1230       1240       1250       1260
ctctttcaag agtcgtcctc cgggggcggt gcagaaccca gctttgggtc cggcctcccg
      1270       1280       1290       1300       1310       1320
ctgccgccag ggggcgcggg gccggaggac ccttctcttt cggtgaccct ggccgacatc
      1330       1340       1350       1360       1370       1380
taccgggagc tctacgcctt cttcggtgac agcttggcca cacgctttgg caccggccag
      1390       1400       1410       1420       1430       1440
cctgcaccca cggctccgcg gccgcccggg gacaagaagg agccggcggc agccccggac
      1450       1460       1470       1480       1490       1500
tcggtgcgga agatgccgca gctgacggca agcgccatag tcagcccgca cggcgacgag
      1510       1520       1530       1540       1550       1560
agcccccggg gcagcggcgg aggcggcccc gcgtcggcct ctgggcccgc cgcctctgag
      1570       1580       1590       1600       1610       1620
agcaggccct tgccgcgcgt gcatcgggcg cgcggggcac cccggcagca gggccccggg
      1630       1640       1650       1660       1670       1680
accggcaccc gcgacgtttt ccagaagagc cgtttcgccc cgcgcggcgc cccgcacttt
      1690       1700       1710       1720       1730       1740
cgtttcatca tagccgggcg gcaggctggg aggcgctgcc gcgggcgcct tttccagact
      1750       1760       1770       1780       1790       1800
gccttccccg cgccgtacgg gcctagcccg gcctcgcgct acgtgcagaa actgcccatg
      1810       1820       1830       1840       1850       1860
atcggccgta ccagccgccc cgcccgccgg tgggcgctct cggactactc gctgtacttg

ccgctctga     

Last modification date: Oct. 2, 2011