Mus musculus L. (mouse) [MMU]

FULL NAME: TFIIH basal transcription factor complex helicase XPB subunit


DESCRIPTION:
ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.

STRUCTURE SIMILARITY:
Contains 1 helicase C-terminal domain.
Contains 1 helicase ATP-binding domain.
Belongs to the helicase family. RAD25/XPB subfamily.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MGKRDRVDRD KKKSKKRQYE EEEEDEDDIP GNESQEAVPS AAGKQVDESS TKVDEYGAKD
        70         80         90        100        110        120
YRQQMPLKGD HTSRPLWVAP DGHIFLEAFS PVYKYAQDFL VAIAEPVCRP THVHEYKLTA
       130        140        150        160        170        180
YSLYAAVSVG LQTSDITEYL RKLSKTGVPD GIIQFIKLCT VSYGKVKLVL KHNRYFVESS
       190        200        210        220        230        240
HPDVIQHLLQ DPVIRECRLR NAEGEATELI TETFTSKSAI SKTAAEGSGG PSTSQGVDAQ
       250        260        270        280        290        300
ATSDIPKDLF DFYEQMDKDE EEEEETQTVS FEVKQEMIEE LQKRCICLEY PLLAEYDFRN
       310        320        330        340        350        360
DTLNPDINID LKPTAVLRPY QEKSLRKMFG NGRARSGVIV LPCGAGKSLV GVTAACTVRK
       370        380        390        400        410        420
RCLVLGNSAV SVEQWKAQFK MWSTIDDSQI CRFTSDAKDK PIGCSVAIST YSMLGHTTKR
       430        440        450        460        470        480
SWEAERVMEW LKTQEWGLMI LDEVHTIPAR MFRRVLTIVQ AHCKLGLTAT LVREDDKIVD
       490        500        510        520        530        540
LNFLIGPKLY EANWMELQNN GYIAKVQCAE VWCPMSPEFY REYVAIKTKK RILLYTMNPN
       550        560        570        580        590        600
KFRACQFLIK FHERRNDKII VFADNVFALK EYAIRLNKPY IYGPTSQGER MQILQNFKHN
       610        620        630        640        650        660
PKINTIFISK VGDTSFDLPE ANVLIQISSH GGSRRQEAQR LGRVLRAKKG MVAEEYNAFF
       670        680        690        700        710        720
YSLVSQDTQE MAYSTKRQRF LVDQGYSFKV ITKLAGMEEE ELAFSTKEEQ QQLLQKVLAA
       730        740        750        760        770        780
TDLDAEEEVV AGEFGSRSGQ ASRRCGTMSS LSGADDTVYM EYHSSRSKAS SKHVHPLFKR

FRK     

Encoded by Ercc3 gene

FULL NAME: excision repair cross-complementing rodent repair deficiency, complementation group 3


OTHER NAME(S):
BTF2_p89
Ercc-3
XPB
BTF2 p89


Nucleic acid sequence

        10         20         30         40         50         60
atgggcaaaa gagatcgagt ggaccgcgac aaaaagaaat ccaagaagag gcagtatgaa
        70         80         90        100        110        120
gaggaagagg aagacgaaga cgacattcct gggaacgagt ctcaggaggc ggtgccctcc
       130        140        150        160        170        180
gccgctggga aacaggtgga cgagtccagc accaaagtgg atgagtatgg agcaaaggac
       190        200        210        220        230        240
tacagacagc agatgccact aaagggtgac catacctcca ggcccctctg ggtggctcct
       250        260        270        280        290        300
gatggccaca ttttcttgga agccttctct ccagtttaca aatatgccca agacttcctg
       310        320        330        340        350        360
gtggcaattg cagagccggt gtgccggcct actcatgtac atgaatacaa gctaaccgcc
       370        380        390        400        410        420
tactccctct atgcagcggt cagtgttggg ctgcaaacca gtgacattac tgagtacctc
       430        440        450        460        470        480
agaaagctca gtaagactgg agttcctgat ggaattatcc agtttattaa gctgtgcact
       490        500        510        520        530        540
gtcagctatg ggaaggtcaa gctggtcctc aagcacaaca ggtactttgt tgaaagttcc
       550        560        570        580        590        600
caccctgatg ttatccagca tcttcttcaa gacccagtga tccgggaatg tcgcttgagg
       610        620        630        640        650        660
aacgccgagg gcgaggccac cgaactcatc acagagactt ttacaagcaa atctgctatt
       670        680        690        700        710        720
tctaagacgg cggcggaagg cagtggcggg ccttctactt cgcagggggt agatgcacag
       730        740        750        760        770        780
gccacgtctg acatacccaa agacctgttt gatttttatg agcaaatgga caaggatgag
       790        800        810        820        830        840
gaggaggagg aagagacaca gacagtgtcc tttgaagtta agcaggaaat gatcgaggag
       850        860        870        880        890        900
ctgcagaagc gctgcatctg cttagagtac ccgctgctgg cagagtatga cttccggaat
       910        920        930        940        950        960
gacactctca atcctgacat caacattgac ctgaagccca cagccgtact cagaccctat
       970        980        990       1000       1010       1020
caggagaaga gcctgcggaa gatgtttggg aacggacgag cacgctcagg agtcattgtt
      1030       1040       1050       1060       1070       1080
cttccctgtg gtgctgggaa gtccctggtc ggcgtgactg ccgcatgcac tgtcagaaag
      1090       1100       1110       1120       1130       1140
cgctgtctcg tcctgggcaa ctcggctgtg tctgtggagc agtggaaagc ccagtttaag
      1150       1160       1170       1180       1190       1200
atgtggtcaa ccatcgatga cagccagatc tgccgcttca cctcagatgc caaggacaag
      1210       1220       1230       1240       1250       1260
cccatcggct gctccgttgc cattagcact tactctatgc tgggccacac caccaaaagg
      1270       1280       1290       1300       1310       1320
tcctgggaag ctgagagagt catggagtgg ctcaaaaccc aggagtgggg cctcatgatc
      1330       1340       1350       1360       1370       1380
cttgacgagg tgcacaccat tccagccagg atgttccggc gggttctgac tattgtgcag
      1390       1400       1410       1420       1430       1440
gcgcactgta agcttggttt gactgcaacc cttgtccggg aagatgacaa aattgttgac
      1450       1460       1470       1480       1490       1500
ttaaatttcc tgattgggcc caagctctat gaagccaact ggatggagct gcagaacaat
      1510       1520       1530       1540       1550       1560
gggtacatcg ctaaagtcca gtgtgctgag gtttggtgcc cgatgtctcc cgagttctac
      1570       1580       1590       1600       1610       1620
cgagagtatg tggcaatcaa aacaaagaaa cggatcctgt tgtacaccat gaatcccaac
      1630       1640       1650       1660       1670       1680
aaattcagag cctgccagtt tctgatcaag tttcatgaaa ggaggaatga caagattatt
      1690       1700       1710       1720       1730       1740
gtctttgctg acaacgtatt tgccttgaag gaatatgcca ttcggctgaa caaaccttat
      1750       1760       1770       1780       1790       1800
atctacgggc ccacgtccca gggagaacgt atgcagattc tccagaactt caagcacaac
      1810       1820       1830       1840       1850       1860
cccaaaatca acaccatctt catctccaag gttggtgaca catcctttga tctgccagaa
      1870       1880       1890       1900       1910       1920
gccaatgtcc tcattcagat ctcttcccat ggtggctccc gacggcagga agcccagaga
      1930       1940       1950       1960       1970       1980
ctgggacggg tactcagagc caagaaaggg atggtcgcag aggaatacaa tgcctttttc
      1990       2000       2010       2020       2030       2040
tactccctgg tatctcagga cacacaggaa atggcttatt ctaccaagcg acagagattc
      2050       2060       2070       2080       2090       2100
ctagtggatc aaggttacag ctttaaggta atcacaaagc tagctggcat ggaggaagag
      2110       2120       2130       2140       2150       2160
gagctggcgt tctccaccaa agaggagcag cagcagctcc tgcagaaggt gctggcagcc
      2170       2180       2190       2200       2210       2220
accgacttgg atgcagagga ggaagtggtg gctggagagt ttggctctag atctggccag
      2230       2240       2250       2260       2270       2280
gcatcccgac gctgtggcac catgagctcc ctgtcaggcg cagacgacac cgtgtacatg
      2290       2300       2310       2320       2330       2340
gagtaccact cctcccgaag caaggcctcc agcaagcacg tgcacccgct tttcaaacgc
      2350
ttcaggaagt ga    

Last modification date: Oct. 2, 2011