Mus musculus L. (mouse) [MMU]

FULL NAME: Cyclin-H


DESCRIPTION:
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

STRUCTURE SIMILARITY:
Belongs to the cyclin family. Cyclin C subfamily.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MYHSSSQKRH WTFASEEQLA RLRADANRKF KCKAVANGKV LPNDPVFLEP HEELTLCKYY
        70         80         90        100        110        120
EKRLLEFCSV FKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV
       130        140        150        160        170        180
SSPQFVGNLR ESPLGQERAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDIKTRYPM
       190        200        210        220        230        240
LENPEILRKT ADDFLSRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE
       250        260        270        280        290        300
NRTCLSQLLD IMKSMRNLVK KYEPPRSDEV AVLKQKLERC HSSDLALNAV TKKRKGYEDD
       310        320
DYVSKKPKQE EEEWTDDDLV DSL   

Encoded by Ccnh gene

FULL NAME: cyclin H


OTHER NAME(S):
6330408H09Rik
AI661354
AV102684
AW538719


Nucleic acid sequence

        10         20         30         40         50         60
atgtatcaca gcagcagcca gaaacggcac tggaccttcg ctagcgagga gcagctggcg
        70         80         90        100        110        120
cgcctgcggg cggacgccaa ccgcaaattc aagtgcaaag ctgtggctaa cgggaaggtt
       130        140        150        160        170        180
cttccaaatg atccagtgtt tctggagcct catgaagaat tgacactttg caagtactat
       190        200        210        220        230        240
gaaaaaagat tattggaatt ctgttcagtg tttaaaccag ctatgccacg gtctgttgtg
       250        260        270        280        290        300
ggtacagctt gtatgtattt caagcgtttt tatcttaata actcagtaat ggaatatcac
       310        320        330        340        350        360
cctcggataa taatgcttac ttgtgcattt ttggcctgca aagtagatga attcaatgtg
       370        380        390        400        410        420
tctagtcccc agtttgttgg aaatcttcga gagagtcctc ttggacagga gagggcactg
       430        440        450        460        470        480
gaacagattt tggaatatga actactactt atacaacaac ttaattttca ccttattgtc
       490        500        510        520        530        540
cacaatccat acagaccatt tgaaggcttc ctcatcgata taaagactcg gtaccccatg
       550        560        570        580        590        600
ttggagaatc cggagattct gaggaaaaca gctgatgatt ttcttagtag aattgcattg
       610        620        630        640        650        660
acagatgctt atcttttata cacaccttca cagattgccc tgaccgccat tttatcaagt
       670        680        690        700        710        720
gcctctagag ctggaattac tatggaaagc tacttatcag agagtctaat gctaaaagaa
       730        740        750        760        770        780
aacagaactt gcctgtcaca gttactggat ataatgaaaa gcatgagaaa tctagtaaaa
       790        800        810        820        830        840
aagtacgagc cgcccaggtc tgacgaggtt gctgtcctga aacagaagct ggagcggtgt
       850        860        870        880        890        900
cattcttctg accttgcact taatgcggtt acgaagaaga ggaaaggcta tgaagatgat
       910        920        930        940        950        960
gactatgtgt caaagaaacc caaacaggaa gaggaggaat ggactgatga cgacctggta
       970
gattctctct aa    

Last modification date: Oct. 2, 2011