Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor TFIID subunit 5


DESCRIPTION:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

STRUCTURE SIMILARITY:
Belongs to the WD repeat TAF5 family.
Contains 6 WD repeats.
Contains 1 LisH domain.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTT NNGPNGGGGN VAASSSTGGD
        70         80         90        100        110        120
GGTPKPTVAV SAAAPAGAAP VPAAAPDAGA PHDRQTLLAV LQFLRQSKLR EAEEALRREA
       130        140        150        160        170        180
GLLEEAVAGS GAPGEVDSAG AEVTSALLSR VTASAPGPAA PDPPGTGASG ATVVSGSASG
       190        200        210        220        230        240
PAAPGKVGSV AVEDQPDVSA VLSAYNQQGD PTMYEEYYSG LKHFIECSLD CHRAELSQLF
       250        260        270        280        290        300
YPLFVHMYLE LVYNQHENEA KSFFEKFHGD QECYYQDDLR VLSSLTKKEH MKGNETMLDF
       310        320        330        340        350        360
RTSKFVLRIS RDSYQLLKRH LQEKQNNQIW NIVQEHLYID IFDGMPRSKQ QIDAMVGSLA
       370        380        390        400        410        420
GEAKREANKS KVFFGLLKEP EIEVPLDDED EEGENEEGKP KKKKPKKDSI GSKSKKQDPN
       430        440        450        460        470        480
APPQNRIPLP ELKDSDKLDK IMNMKETTKR VRLGPDCLPS ICFYTFLNAY QGLTAVDVTD
       490        500        510        520        530        540
DSSLIAGGFA DSTVRVWSVT PKKLRSVKQA SDLSLIDKES DDVLERIMDE KTASELKILY
       550        560        570        580        590        600
GHSGPVYGAS FSPDRNYLLS SSEDGTVRLW SLQTFTCLVG YKGHNYPVWD TQFSPYGYYF
       610        620        630        640        650        660
VSGGHDRVAR LWATDHYQPL RIFAGHLADV NCTRFHPNSN YVATGSADRT VRLWDVLNGN
       670        680        690        700        710        720
CVRIFTGHKG PIHSLTFSPN GRFLATGATD GRVLLWDIGH GLMVGELKGH TDTVCSLRFS
       730        740        750        760        770        780
RDGEILASGS MDNTVRLWDA IKAFEDLETD DFTTATGHIN LPENSQELLL GTYMTKSTPV
       790        800
VHLHFTRRNL VLAAGAYSPQ    

Encoded by TAF5 gene

FULL NAME: TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa


OTHER NAME(S):
TAF2D
TAFII100


DESCRIPTION:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggcgc tggcggagga gcagacggag gtggcggtca agctagagcc tgagggaccg
        70         80         90        100        110        120
ccaacgctgc tacctccgca ggcgggggac ggcgcaggcg agggtagcgg cggcactacc
       130        140        150        160        170        180
aacaacggcc ccaacggcgg cggcgggaac gttgcggcgt cgtcgtccac tggcggggat
       190        200        210        220        230        240
ggcgggaccc ccaagcccac ggtggctgtc tccgccgctg ccccggcggg ggcggccccg
       250        260        270        280        290        300
gtgcccgccg ctgctccgga cgccggcgct ccgcatgacc gacagactct actggccgtg
       310        320        330        340        350        360
ctgcagttcc tacggcagag caaactccgc gaggccgaag aggcgctgcg ccgtgaggcc
       370        380        390        400        410        420
gggctgctgg aggaggcagt ggcgggctcc ggagccccgg gagaggtgga cagcgccggc
       430        440        450        460        470        480
gctgaggtga ccagcgcgct tctcagccgg gtgaccgcct cggcccctgg ccctgcggcc
       490        500        510        520        530        540
cccgaccctc cgggcactgg cgcttcgggg gccacggtcg tctcaggttc agcctcaggt
       550        560        570        580        590        600
cctgcggctc cgggtaaagt tggaagtgtt gctgtggaag accagccaga tgtcagtgcc
       610        620        630        640        650        660
gtgttgtcag cctacaacca acaaggagat cccacaatgt atgaagaata ctatagtgga
       670        680        690        700        710        720
ctgaaacact tcattgaatg ttccctggac tgccatcggg cagagttgtc ccaacttttt
       730        740        750        760        770        780
tatcctctgt ttgtgcacat gtacttggag ctagtctaca atcaacatga gaatgaagca
       790        800        810        820        830        840
aagtcattct ttgagaagtt ccatggagat caggaatgtt attaccagga tgacctacga
       850        860        870        880        890        900
gtattatcta gtcttaccaa aaaggaacac atgaaaggga atgagaccat gttggatttt
       910        920        930        940        950        960
cgaacaagta aatttgttct gcgtatttcc cgtgactcgt accaactctt gaagaggcat
       970        980        990       1000       1010       1020
cttcaggaga aacagaacaa tcagatatgg aacatagttc aggagcacct ctacattgac
      1030       1040       1050       1060       1070       1080
atctttgatg ggatgccgcg tagtaagcaa cagatagatg cgatggtggg aagtttggca
      1090       1100       1110       1120       1130       1140
ggagaggcta aacgagaggc aaacaaatca aaggtatttt ttggtttatt aaaagaacca
      1150       1160       1170       1180       1190       1200
gaaattgagg tacctttgga tgacgaggat gaagagggag aaaatgaaga aggaaaacct
      1210       1220       1230       1240       1250       1260
aaaaagaaga agcctaaaaa agatagtatt ggatccaaaa gcaaaaaaca agatcccaat
      1270       1280       1290       1300       1310       1320
gctccacctc agaacagaat ccctcttcct gagttgaaag attcagataa gttggataag
      1330       1340       1350       1360       1370       1380
ataatgaata tgaaagaaac caccaaacga gtgcgccttg ggccggactg cttaccctcc
      1390       1400       1410       1420       1430       1440
atttgtttct atacatttct caatgcttac cagggtctca ctgcagtgga tgtcactgat
      1450       1460       1470       1480       1490       1500
gattctagtc tgattgctgg aggttttgca gattcaactg tcagagtgtg gtcggtaaca
      1510       1520       1530       1540       1550       1560
cccaaaaagc ttcgtagtgt caaacaagca tcagatctta gtcttataga caaagaatca
      1570       1580       1590       1600       1610       1620
gatgatgtct tagaaagaat catggatgag aaaacagcaa gtgagttgaa gattttgtat
      1630       1640       1650       1660       1670       1680
ggtcacagtg ggcctgtcta cggagccagc ttcagtccgg ataggaacta tctgctttcc
      1690       1700       1710       1720       1730       1740
tcttcagagg acggaactgt tagattgtgg agccttcaaa catttacttg tttggtggga
      1750       1760       1770       1780       1790       1800
tataaaggac acaactatcc agtatgggac acacaatttt ctccatatgg atattatttt
      1810       1820       1830       1840       1850       1860
gtgtcagggg gccatgaccg agtagctcgg ctctgggcta cagaccacta tcagccttta
      1870       1880       1890       1900       1910       1920
agaatatttg ccggccatct tgctgatgtg aattgtacca gattccatcc aaattctaat
      1930       1940       1950       1960       1970       1980
tatgttgcta cgggctctgc agacagaact gtgcggctct gggacgtcct gaatggtaac
      1990       2000       2010       2020       2030       2040
tgtgtaagga tcttcactgg acacaaggga ccaattcatt ccttgacatt ttctcccaat
      2050       2060       2070       2080       2090       2100
gggagattcc tggctacagg agcaacagat ggcagagtgc ttctttggga tattggacat
      2110       2120       2130       2140       2150       2160
ggtttgatgg ttggagaatt aaaaggccac actgatacag tctgttcact taggtttagt
      2170       2180       2190       2200       2210       2220
agagatggtg aaattttggc atcaggttca atggataata cagttcgatt atgggatgct
      2230       2240       2250       2260       2270       2280
atcaaagcct ttgaagattt agagaccgat gactttacta cagccactgg gcatataaat
      2290       2300       2310       2320       2330       2340
ttacctgaga attcacagga gttattgttg ggaacatata tgaccaaatc aacaccagtt
      2350       2360       2370       2380       2390       2400
gtacaccttc attttactcg aagaaacctg gttctagctg caggagctta tagtccacaa

taa     

Last modification date: Oct. 2, 2011