Homo sapiens L. (human) [HSA]

FULL NAME: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L


DESCRIPTION:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

STRUCTURE SIMILARITY:
Belongs to the WD repeat TAF5 family.
Contains 6 WD repeats.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS ESGCANIVSA
        70         80         90        100        110        120
APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF VYLHLNLVQN SPKSTVESFY
       130        140        150        160        170        180
SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ
       190        200        210        220        230        240
SDNNTALCKV LTLHIHLDVQ PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE
       250        260        270        280        290        300
VLQESIKRVK DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK
       310        320
KLKSEPHQVD VSRIHLACDI LEEEV   

Encoded by TAF5L gene

FULL NAME: TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa


OTHER NAME(S):
PAF65B


DESCRIPTION:
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgaaacgag tgcgtaccga gcagattcag atggcagtgt cctgctacct caaacgccgg
        70         80         90        100        110        120
cagtacgtgg actcagatgg tcccctgaag caaggactgc ggctgtcaca gactgctgaa
       130        140        150        160        170        180
gagatggcgg ccaatctaac agtgcaatca gaatctggtt gtgccaacat agtgtctgca
       190        200        210        220        230        240
gccccttgcc aggcagaacc ccagcaatat gaagtacagt ttggacgact gcggaatttt
       250        260        270        280        290        300
ctcactgatt ctgattccca gcatagccac gaagtgatgc ctctcctcta tcctctcttt
       310        320        330        340        350        360
gtctacctcc atctcaacct ggtccaaaac agtccgaaga gcacagtgga aagtttttac
       370        380        390        400        410        420
agccgcttcc atggaatgtt tctgcagaat gctagccaga aggatgtcat tgagcagcta
       430        440        450        460        470        480
cagaccactc aaaccatcca ggacatccta tctaacttca agcttcgagc attcctagat
       490        500        510        520        530        540
aacaagtacg tggtccgtct ccaagaagac agctacaact accttatccg ctacctccaa
       550        560        570        580        590        600
agtgacaaca atactgccct gtgcaaagtc ctcaccttac atattcatct tgacgtgcag
       610        620        630        640        650        660
cctgccaaga gaacagacta tcagctgtat gccagtggca gctcctcccg cagtgagaac
       670        680        690        700        710        720
aacggtttgg agccccccga catgcccagc cctattctgc agaacgaggc tgccctagag
       730        740        750        760        770        780
gtcttacagg agagcattaa gcgagtcaag gatgggcctc cctccctcac taccatctgc
       790        800        810        820        830        840
ttctatgcct tctataacac agagcagctg ttgaacactg cagaaatctc ccccgatagc
       850        860        870        880        890        900
aagctgcttg ctgctgggtt tgacaactcc tgtataaaac tttggagttt acgatccaag
       910        920        930        940        950        960
aagttaaaat cagagcccca ccaagtagac gtgtcccgca tccatttggc ttgtgatatt
       970
ctggaggagg aggtatga    

Last modification date: Oct. 2, 2011