Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: DNA polymerase III subunit delta


DESCRIPTION:
DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.

CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MIRLYPEQLR AQLNEGLRAA YLLLGNDPLL LQESQDAVRQ VAAAQGFEEH HTFSIDPNTD
        70         80         90        100        110        120
WNAIFSLCQA MSLFASRQTL LLLLPENGPN AAINEQLLTL TGLLHDDLLL IVRGNKLSKA
       130        140        150        160        170        180
QENAAWFTAL ANRSVQVTCQ TPEQAQLPRW VAARAKQLNL ELDDAANQVL CYCYEGNLLA
       190        200        210        220        230        240
LAQALERLSL LWPDGKLTLP RVEQAVNDAA HFTPFHWVDA LLMGKSKRAL HILQQLRLEG
       250        260        270        280        290        300
SEPVILLRTL QRELLLLVNL KRQSAHTPLR ALFDKHRVWQ NRRGMMGEAL NRLSQTQLRQ
       310        320        330        340
AVQLLTRTEL TLKQDYGQSV WAELEGLSLL LCHKPLADVF IDG 

Encoded by holA gene


OTHER NAME(S):
ECK0633
JW0635


DESCRIPTION:
Some delta exists independent of the preinitiation complex, possibly playing a role in stripping beta clamps from DNA in the absence of replication initiation . [More information is available at EcoCyc: EG11412].


Nucleic acid sequence

        10         20         30         40         50         60
atgattcggt tgtacccgga acaactccgc gcgcagctca atgaagggct gcgcgcggcg
        70         80         90        100        110        120
tatcttttac ttggtaacga tcctctgtta ttgcaggaaa gccaggacgc tgttcgtcag
       130        140        150        160        170        180
gtagctgcgg cacaaggatt cgaagaacac cacacttttt ccattgatcc caacactgac
       190        200        210        220        230        240
tggaatgcga tcttttcgtt atgccaggct atgagtctgt ttgccagtcg acaaacgcta
       250        260        270        280        290        300
ttgctgttgt taccagaaaa cggaccgaat gcggcgatca atgagcaact tctcacactc
       310        320        330        340        350        360
accggacttc tgcatgacga cctgctgttg atcgtccgcg gtaataaatt aagcaaagcg
       370        380        390        400        410        420
caagaaaatg ccgcctggtt tactgcgctt gcgaatcgca gcgtgcaggt gacctgtcag
       430        440        450        460        470        480
acaccggagc aggctcagct tccccgctgg gttgctgcgc gcgcaaaaca gctcaactta
       490        500        510        520        530        540
gaactggatg acgcggcaaa tcaggtgctc tgctactgtt atgaaggtaa cctgctggcg
       550        560        570        580        590        600
ctggctcagg cactggagcg tttatcgctg ctctggccag acggcaaatt gacattaccg
       610        620        630        640        650        660
cgcgttgaac aggcggtgaa tgatgccgcg catttcaccc cttttcattg ggttgatgct
       670        680        690        700        710        720
ttgttgatgg gaaaaagtaa gcgcgcattg catattcttc agcaactgcg tctggaaggc
       730        740        750        760        770        780
agcgaaccgg ttattttgtt gcgcacatta caacgtgaac tgttgttact ggttaacctg
       790        800        810        820        830        840
aaacgccagt ctgcccatac gccactgcgt gcgttgtttg ataagcatcg ggtatggcag
       850        860        870        880        890        900
aaccgccggg gcatgatggg cgaggcgtta aatcgcttaa gtcagacgca gttacgtcag
       910        920        930        940        950        960
gccgtgcaac tcctgacacg aacggaactc accctcaaac aagattacgg tcagtcagtg
       970        980        990       1000       1010       1020
tgggcagagc tggaagggtt atctcttctg ttgtgccata aacccctggc ggacgtattt
      1030
atcgacggtt ga    

Last modification date: Oct. 2, 2011