Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Transcription initiation factor TFIID subunit 2


DESCRIPTION:
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of transcription (By similarity).

STRUCTURE SIMILARITY:
Belongs to the TAF2 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSQLVDVPAR GHQKVAIDID FASQTIIGRT DITVNPIDSN LQKIVLDCYQ AEIHSVYVNG
        70         80         90        100        110        120
DLTKFSYSDA LKKLRIDEPN STVNQHHQLN LQYEALMNDL GGINIFLSKP PGDELRPLIV
       130        140        150        160        170        180
SIDFSVHQPI FGITFVGIDP VDHRYPHVFT NNSIIPYSTC SWLPCVDGIW ERSTWEFEIT
       190        200        210        220        230        240
LPKTLSSLMH REKTQPSDLN NGANGVDGHD DNYENNRFDH QFNLSNEPDL LEDHDIEVIC
       250        260        270        280        290        300
CGDLLDQVTH PKDMRKKTVY FSVTTPVAPN YIAFAAGPFK HINLTDFREP EDDDAMGSSA
       310        320        330        340        350        360
IDITGYYLPK YAEEVENTCV FLYKAMDFFV REYGSYPFNS FKLCFVDETN FPIISTPSLV
       370        380        390        400        410        420
ISSNSILYPK DSLDQIYDST KTLTWALASQ WIGVYLIPKA WSDLWLIYGL SYYICGLFLK
       430        440        450        460        470        480
KLMGNNDYRF RLKKQVYRLL ELDIGKPPIS QRNINIPIDP NTLDFIALKS PLVIHILERR
       490        500        510        520        530        540
LTKTGGSLGM SRVIPKLLLQ VMSGDMLNGC LSTSHFLKTC EKASHMRLDV FAQQWIYGYG
       550        560        570        580        590        600
YPIFRVVQRF NRKKMIIEMG IDQVQTKEAP RAPMSDKNFL SDAIRHLNNE SIPTGLPVFS
       610        620        630        640        650        660
GPMTIRIHEA DGTPYEHVVE LKDSFTKLDI QYNTKYKRIS RNRSTKNVKR DGDHNGDDSD
       670        680        690        700        710        720
YVIRSLGDVL QSDEDIERWH LYDYTKEEED TMATEAFEWI RVDADFEWIC DLRVRQPEHM
       730        740        750        760        770        780
YVSQLQQDRD VVAQLETIRH FTSESFTVSQ QVSTVLLRTL LDNRYYYGIR QEAARALARC
       790        800        810        820        830        840
AIPELDWVGY YHLRMAYLEK FCFKDSTIPK SNDFSNITEY YVKCAMLESF PNIRDRKGVT
       850        860        870        880        890        900
PSSVKKLLLD LLCYNDNANN EFSDAYFICL LIDSLVEGLI PRGETVQYAF SDPEHMEFVN
       910        920        930        940        950        960
QVINEIDRYM RIDACMPSFK NIITCKSLKA KLRLAQTFHL EFGPKELLPY TQEGNYVLVR
       970        980        990       1000       1010       1020
CIAFNLMLQA GALKYTPLIK YIFYILTNDL SPVVRRSLLY SVQDGLGALA RGGTKSDVAS
      1030       1040       1050       1060       1070       1080
EDLIVEEDIT KAVEKRIDIT SRASISGAIE ALRNDLGQNH DFATEIWNAI NNPKSDLLTK
      1090       1100       1110       1120       1130       1140
RNLLMICRVL YKAKSSLLVT LKIPSLIPRL RAIHLGKGKI VIKKAPLKQI TSKTKEKSTS
      1150       1160       1170
PTPPSITINP IKPKGPTLKI KLTNLRSTPP SH  

Encoded by taf2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcacaat tggtggatgt acccgctcgt ggtcaccaga aagttgctat tgacatagat
        70         80         90        100        110        120
tttgcttcac aaaccataat tggaaggacg gatataacag ttaatcctat agactcaaat
       130        140        150        160        170        180
ttgcaaaaaa ttgtattaga ttgctaccag gctgaaatcc attcagttta tgtaaacggg
       190        200        210        220        230        240
gatctaacta aattttccta tagtgatgct ttaaagaaac tacgtattga tgaaccaaat
       250        260        270        280        290        300
tcaacggtaa atcaacatca tcaacttaat ttacagtatg aagcattgat gaatgatttg
       310        320        330        340        350        360
ggaggtatca atatattcct tagcaagcct cctggcgatg agctaaggcc actaattgtt
       370        380        390        400        410        420
tcaattgatt tttcagttca tcaacctatt ttcgggatta catttgttgg tatcgatcct
       430        440        450        460        470        480
gtagatcatc gttatccaca cgtgtttaca aacaattcta taattcctta cagcacttgt
       490        500        510        520        530        540
tcatggcttc cttgtgtcga tggcatttgg gaacgatcga cttgggaatt tgagatcacg
       550        560        570        580        590        600
ttgccaaaaa cactcagctc ccttatgcat cgagaaaaaa ctcagccttc cgacttgaac
       610        620        630        640        650        660
aatggtgcaa atggcgttga tggacatgat gataattacg agaataatag gtttgaccac
       670        680        690        700        710        720
cagtttaact taagtaatga acccgattta cttgaagatc atgatattga agttatttgt
       730        740        750        760        770        780
tgtggcgatc tgctggacca ggtcacccat ccaaaagata tgcgcaaaaa aacggtatat
       790        800        810        820        830        840
tttagtgtga ctactccagt tgctcctaat tatattgctt ttgcggctgg accattcaag
       850        860        870        880        890        900
cacatcaatt tgaccgattt ccgtgaacct gaagatgatg atgctatggg ttctagtgct
       910        920        930        940        950        960
attgatatta caggatatta tctacccaaa tatgctgagg aagttgaaaa cacatgtgtt
       970        980        990       1000       1010       1020
tttttatata aagcaatgga tttttttgtt cgggagtatg gatcatatcc tttcaattca
      1030       1040       1050       1060       1070       1080
ttcaagttgt gttttgtgga tgaaaccaat tttcctatta tttcgacacc ctctttggtc
      1090       1100       1110       1120       1130       1140
atatcaagca attctatttt gtatcctaag gactcgcttg atcaaatata tgactccact
      1150       1160       1170       1180       1190       1200
aaaaccttaa cttgggctct tgctagtcaa tggattggtg tttatctcat tcctaaagca
      1210       1220       1230       1240       1250       1260
tggagtgact tatggttgat atatggttta tcatactata tatgcggact atttttaaag
      1270       1280       1290       1300       1310       1320
aaattaatgg gtaataacga ttatcgtttt cgtttaaaaa aacaggttta tcgactgtta
      1330       1340       1350       1360       1370       1380
gaacttgata ttggcaagcc cccaatatct cagcgcaata taaatatccc tattgatccc
      1390       1400       1410       1420       1430       1440
aatacgctag actttattgc tttgaaatct ccgctggtaa tccacatcct tgaacgacgt
      1450       1460       1470       1480       1490       1500
ttgaccaaaa ccggtggctc attaggaatg tcgagggtta ttcctaaatt acttctccaa
      1510       1520       1530       1540       1550       1560
gttatgagcg gtgatatgct aaatggatgt cttagcacct ctcatttttt gaaaacatgt
      1570       1580       1590       1600       1610       1620
gaaaaagcta gtcacatgcg gctcgacgtt tttgctcaac aatggattta tggctacggc
      1630       1640       1650       1660       1670       1680
tatccaattt ttagagtagt acaaaggttc aatcgtaaga aaatgatcat cgaaatggga
      1690       1700       1710       1720       1730       1740
attgatcagg ttcaaacaaa agaggccccc cgagccccaa tgtctgacaa aaacttttta
      1750       1760       1770       1780       1790       1800
agcgacgcca tccgtcattt gaataacgaa agcattccta ccggccttcc tgttttcagt
      1810       1820       1830       1840       1850       1860
ggacccatga ccattcgaat tcacgaggcc gatggtacac cgtatgaaca cgtggttgag
      1870       1880       1890       1900       1910       1920
ttaaaggatt cttttaccaa actcgatatt caatacaata ctaaatataa aagaattagt
      1930       1940       1950       1960       1970       1980
agaaacaggt ctacaaaaaa tgtcaaaagg gatggtgacc ataatggtga tgattctgac
      1990       2000       2010       2020       2030       2040
tacgttatcc gaagtttggg ggatgttttg caaagtgacg aagatataga gcgttggcat
      2050       2060       2070       2080       2090       2100
ttatatgact atactaaaga agaggaagat acaatggcga ctgaggcttt cgaatggatt
      2110       2120       2130       2140       2150       2160
cgggttgatg cagacttcga atggatttgt gatctacgtg tgcggcagcc ggaacatatg
      2170       2180       2190       2200       2210       2220
tatgtctctc agttacagca agatagagat gtagttgcgc aactagaaac tattcggcac
      2230       2240       2250       2260       2270       2280
tttactagtg agagctttac ggtctctcag caagtttcta ccgttttgct tcgtacacta
      2290       2300       2310       2320       2330       2340
ttggataata ggtattatta tggcattcga caagaagcag cacgtgcctt agcaagatgt
      2350       2360       2370       2380       2390       2400
gctattcctg aacttgattg ggttggatat tatcatcttc gcatggctta tttagaaaaa
      2410       2420       2430       2440       2450       2460
ttttgtttta aagactctac tattcccaag agcaacgatt tttctaatat aacggaatac
      2470       2480       2490       2500       2510       2520
tatgttaaat gcgcaatgct tgagtccttt cccaatattc gtgatcgcaa gggggttaca
      2530       2540       2550       2560       2570       2580
ccttcatccg ttaaaaagtt acttttggat ttgctgtgtt ataatgataa tgctaataac
      2590       2600       2610       2620       2630       2640
gagttttccg atgcttattt tatatgctta ttgatagatt ctttggtaga aggattaatt
      2650       2660       2670       2680       2690       2700
cctcgtggag aaacagttca atatgcgttt agcgatccgg aacacatgga attcgtcaat
      2710       2720       2730       2740       2750       2760
caagttatta atgaaattga tcgatatatg agaattgatg cctgtatgcc gtcgtttaaa
      2770       2780       2790       2800       2810       2820
aatattatta cttgcaagtc tttaaaagca aaattgcgat tggctcaaac attccatctg
      2830       2840       2850       2860       2870       2880
gagttcggac caaaagagtt attaccatat actcaagaag gcaattatgt attagtgcga
      2890       2900       2910       2920       2930       2940
tgcatcgctt tcaatttgat gctacaagca ggggctctta aatatactcc tttgatcaag
      2950       2960       2970       2980       2990       3000
tacatcttct atattcttac caatgattta tcaccggttg tccgaagatc cttgctttat
      3010       3020       3030       3040       3050       3060
tctgttcaag acggattagg tgctttggct agaggtggaa ctaaatcgga cgttgcatcc
      3070       3080       3090       3100       3110       3120
gaggacctaa ttgtcgaaga ggatattaca aaagccgttg agaagagaat tgatatcaca
      3130       3140       3150       3160       3170       3180
tcccgtgcca gtatatcagg tgctatagag gctcttagaa atgaccttgg tcagaatcac
      3190       3200       3210       3220       3230       3240
gattttgcaa ctgaaatttg gaatgccata aataatccaa aatcggattt gcttactaaa
      3250       3260       3270       3280       3290       3300
agaaatcttc ttatgatttg tcgcgtactc tacaaagcaa agtcatctct tttggtgacg
      3310       3320       3330       3340       3350       3360
cttaaaatac caagtttaat accacgctta cgtgctatac atttgggaaa aggaaagatt
      3370       3380       3390       3400       3410       3420
gtaattaaaa aagctccctt gaagcaaata actagcaaaa caaaagaaaa gtccacgagt
      3430       3440       3450       3460       3470       3480
cctactcccc cgtcaataac aatcaatcct attaaaccaa agggacctac tttgaaaata
      3490       3500       3510
aagctaacaa atctccgctc tactccacct tctcattga  

Last modification date: Oct. 2, 2011