Homo sapiens L. (human) [HSA]


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MPLTGVEPAR MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE LTIFPTVANL
        70         80         90        100        110        120
NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ RNLNYFSNAY AAAVSAVDPD
       130        140        150        160        170        180
AGNGELCIKV PSELWKHVDE LKVLKIHINF SLDQPKGGLH FVVPSVEGSM AERGAHVFSC
       190        200        210        220        230        240
GYQNSTRFWF PCVDSYSELC TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI
       250        260        270        280        290        300
PTAASNISLA IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYLHEVFEF YEEILTCRYP
       310        320        330        340        350        360
YSCFKTVFID EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQSL AQQFFGCFIS
       370        380        390        400        410        420
RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YRHWIKEELD KIVAYELKTG GVLLHPIFGG
       430        440        450        460        470        480
GKEKDNPASH LHFSIKHPHT LSWEYYTMFQ CKAHLVMRLI ENRISMEFML QVFNKLLSLA
       490        500        510        520        530        540
STASSQKFQS HMWSQMLVST SGFLKSISNV SGKDIQPLIK QWVDQSGVVK FYGSFAFNRK
       550        560        570        580        590        600
RNVLELEIKQ DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK
       610        620        630        640        650        660
KKKIPLMNGE EVDMDLSAMD ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ YQLRYERDVV
       670        680        690        700        710        720
AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF CLAKIANSMV STWTGPPAMK
       730        740        750        760        770        780
SLFTRMFCCK SCPNIVKTNN FMSFQSYFLQ KTMPVAMALL RDVHNLCPKE VLTFILDLIK
       790        800        810        820        830        840
YNDNRKNKFS DNYYRAEMID ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME
       850        860        870        880        890        900
KLLPSYRHTI TVSCLRAIRV LQKNGHVPSD PALFKSYAEY GHFVDIRIAA LEAVVDYTKV
       910        920        930        940        950        960
DRSYEELQWL LNMIQNDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV DQLWKLMNSG
       970        980        990       1000       1010       1020
TSHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE KKAVLNPTII PESVAGNQEA
      1030       1040       1050       1060       1070       1080
ANNPSSHPQL VGFQNPFSSS QDEEEIDMDT VHDSQAFISH HLNMLERPST PGLSKYRPAS
      1090       1100       1110       1120       1130       1140
SRSALIPQHS AGCDSTPTTK PQWSLELARK GTGKEQAPLE MSMHPAASAP LSVFTKESTA
      1150       1160       1170       1180       1190
SKHSDHHHHH HHEHKKKKKK HKHKHKHKHK HDSKEKDKEP FTFSSPASGR SIRSPSLSD

Encoded by TAF2 gene

FULL NAME: TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa


OTHER NAME(S):
CIF150
TAF2B
TAFII150


DESCRIPTION:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgccgctga ctggtgtaga gcccgccaga atgaacagga agaaaggaga caagggcttt
        70         80         90        100        110        120
gaaagcccaa ggccatataa attaacccat caggtcgtct gcatcaacaa cataaatttc
       130        140        150        160        170        180
cagagaaaat ctgttgtggg atttgtggaa ctgactatat ttcccacagt tgcaaacttg
       190        200        210        220        230        240
aatagaatca agttgaacag caaacagtgt agaatatacc gagtaaggat caatgattta
       250        260        270        280        290        300
gaggctgctt ttatttataa tgacccaacc ttggaagttt gtcacagtga atcaaaacag
       310        320        330        340        350        360
agaaacctca attatttttc caatgcttat gcagctgcag ttagtgctgt ggaccctgat
       370        380        390        400        410        420
gcaggaaatg gagaactttg cattaaggtt ccatcagagc tatggaaaca cgttgatgag
       430        440        450        460        470        480
ttaaaggtcc tgaagataca catcaatttt tctttggatc agcccaaagg aggtcttcat
       490        500        510        520        530        540
tttgtggtac ccagtgtaga gggaagtatg gcagagagag gtgctcatgt tttctcttgt
       550        560        570        580        590        600
gggtatcaaa attctacaag attttggttc ccttgtgttg attcatactc tgaattgtgt
       610        620        630        640        650        660
acatggaaat tagaatttac agtagatgct gcaatggttg ctgtttctaa tggcgatttg
       670        680        690        700        710        720
gtggagacag tgtatactca tgatatgagg aagaaaactt tccattatat gcttaccatt
       730        740        750        760        770        780
cctacagcag cgtcaaatat ctccttggcc attggaccat ttgaaatact ggtagatcca
       790        800        810        820        830        840
tacatgcatg aggttactca tttttgtttg ccccaacttc ttccattgct gaaacatacc
       850        860        870        880        890        900
acatcatacc ttcatgaagt ctttgaattt tatgaagaaa ttcttacatg tcgttaccca
       910        920        930        940        950        960
tactcctgtt ttaagactgt cttcattgat gaggcttatg ttgaagtggc tgcttatgct
       970        980        990       1000       1010       1020
tccatgagca tttttagcac aaatctttta cacagtgcca tgattataga tgagacacct
      1030       1040       1050       1060       1070       1080
ttgactagaa ggtgtttagc ccaatccttg gcccagcagt tttttggttg tttcatatct
      1090       1100       1110       1120       1130       1140
agaatgtctt ggtctgatga atgggtgctg aagggaattt caggctatat ctatggactt
      1150       1160       1170       1180       1190       1200
tggatgaaaa aaacttttgg tgttaatgag taccgccatt ggattaaaga ggagctagac
      1210       1220       1230       1240       1250       1260
aaaatagtgg catatgaact aaaaactggt ggggttttac tacatcccat atttggtgga
      1270       1280       1290       1300       1310       1320
ggaaaagaga aggataatcc ggcttcccat ctacactttt caataaagca tccacataca
      1330       1340       1350       1360       1370       1380
ctgtcctggg aatactacac tatgtttcag tgtaaagccc accttgtgat gagattgatt
      1390       1400       1410       1420       1430       1440
gaaaatagga tcagtatgga atttatgcta caagttttca ataaactgct aagtctggct
      1450       1460       1470       1480       1490       1500
agtactgctt catctcagaa gttccagtca catatgtgga gtcagatgtt ggtttccaca
      1510       1520       1530       1540       1550       1560
tctgggtttt tgaaatccat ttcaaatgtc tctggcaaag atattcagcc gttaataaag
      1570       1580       1590       1600       1610       1620
cagtgggtag atcagagtgg agtggtaaaa ttttatggaa gttttgcatt taatagaaaa
      1630       1640       1650       1660       1670       1680
cgaaatgtct tggaactgga aataaaacag gactatacat ctcctggaac tcagaaatac
      1690       1700       1710       1720       1730       1740
gtgggaccac ttaaagtgac agtgcaggag ttagatggat ccttcaatca tacactgcaa
      1750       1760       1770       1780       1790       1800
attgaagaaa acagccttaa acatgatata ccctgccatt ccaaaagtag aaggaataaa
      1810       1820       1830       1840       1850       1860
aagaaaaaaa tcccactgat gaatggagaa gaagttgata tggatctttc tgcaatggat
      1870       1880       1890       1900       1910       1920
gctgattccc ctttgctgtg gataaggata gacccagata tgtcagtatt gaggaaggta
      1930       1940       1950       1960       1970       1980
gaatttgagc aagctgattt tatgtggcag tatcagctcc gctatgagag agatgttgtt
      1990       2000       2010       2020       2030       2040
gcacagcagg aatccatttt ggctttggaa aaattcccta ctccagcatc tcggcttgca
      2050       2060       2070       2080       2090       2100
ctcactgata tattagaaca agagcagtgt ttctacagag taagaatgtc agcttgcttc
      2110       2120       2130       2140       2150       2160
tgtcttgcaa agattgcaaa ttcaatggtg agcacatgga caggaccacc agccatgaag
      2170       2180       2190       2200       2210       2220
tcactcttca ctaggatgtt ttgttgtaaa agttgtccaa acattgtgaa aacaaacaac
      2230       2240       2250       2260       2270       2280
tttatgagct ttcaaagcta ttttctacag aagactatgc cagttgcaat ggctttatta
      2290       2300       2310       2320       2330       2340
agagatgttc ataatctttg tcctaaagaa gtcttaacat ttattttaga cttaatcaag
      2350       2360       2370       2380       2390       2400
tacaatgaca acaggaaaaa taagttttca gataactatt atcgtgcaga aatgattgat
      2410       2420       2430       2440       2450       2460
gccctggcca actctgttac acctgcagtc agtgtgaata atgaagttag aactttggat
      2470       2480       2490       2500       2510       2520
aacttaaatc ctgatgtgcg actcattctt gaagaaatca ccagattttt gaatatggaa
      2530       2540       2550       2560       2570       2580
aaacttcttc cgagttacag gcataccatc actgtcagtt gtttgagagc catacgggta
      2590       2600       2610       2620       2630       2640
cttcagaaga acggacatgt gccaagtgat ccagctcttt ttaaatctta tgctgaatat
      2650       2660       2670       2680       2690       2700
ggccactttg tggacattag gatagcagct ttggaagcag ttgttgatta tactaaagtg
      2710       2720       2730       2740       2750       2760
gacagaagtt atgaagaact gcaatggcta cttaatatga ttcagaatga ccctgtaccc
      2770       2780       2790       2800       2810       2820
tatgtaaggc ataagattct caacatgttg actaagaacc caccatttac taagaacatg
      2830       2840       2850       2860       2870       2880
gagtctccct tatgcaatga agccctggta gatcaacttt ggaaacttat gaattctggt
      2890       2900       2910       2920       2930       2940
acttcacatg actggaggtt acggtgtggt gctgtggact tgtacttcac actttttggc
      2950       2960       2970       2980       2990       3000
ctcagtagac cttcctgttt acccttgcca gagcttgggt tggttcttaa tctaaaggag
      3010       3020       3030       3040       3050       3060
aaaaaagctg tcttgaatcc taccataatt ccagagtcag tagcaggcaa ccaagaagct
      3070       3080       3090       3100       3110       3120
gcaaataatc caagcagtca cccacagcta gttggatttc agaacccttt ttccagttct
      3130       3140       3150       3160       3170       3180
caagatgagg aggagattga tatggatact gttcatgata gccaggcctt catttcccat
      3190       3200       3210       3220       3230       3240
catttaaaca tgcttgaaag gccgtcaact ccagggctct cgaaatatcg gccagctagc
      3250       3260       3270       3280       3290       3300
tcccgatctg ctttaatacc ccagcactca gcaggctgtg acagcacacc caccacaaaa
      3310       3320       3330       3340       3350       3360
ccccagtgga gtttggaact tgcacggaag ggaacaggta aagaacaagc acctttggag
      3370       3380       3390       3400       3410       3420
atgagtatgc atccagcggc aagcgctcca ctctcagtct ttactaagga atctacagcc
      3430       3440       3450       3460       3470       3480
tccaaacaca gtgaccacca tcaccaccat caccatgagc acaagaaaaa gaagaagaag
      3490       3500       3510       3520       3530       3540
cataaacata agcacaaaca caagcataag catgacagta aagaaaagga caaggagcct
      3550       3560       3570       3580       3590       3600
ttcactttct ccagccctgc cagtggcagg tctattcgtt ctccttccct ttcagactga

Last modification date: Oct. 2, 2011