Mus musculus L. (mouse) [MMU]

FULL NAME: Cyclin-dependent kinase 7


DESCRIPTION:
Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.


ENZYME REGULATION:
Phosphorylation at Thr-170 is required for enzymatic activity (By similarity).


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MAVDVKSRAK RYEKLDFLGE GQFATVYKAR DKNTNQIVAI KKIKLGHRSE AKDGINRTAL
        70         80         90        100        110        120
REIKLLQELS HPNIIGLLDA FGHKSNISLV FDFMETDLEV IIKDNSLVLT PSHIKAYMLM
       130        140        150        160        170        180
TLQGLEYLHQ HWILHRDLKP NNLLLDENGV LKLADFGLAK SFGSPNRAYT HQVVTRWYRA
       190        200        210        220        230        240
PELLFGARMY GVGVDMWAVG CILAELLLRV PFLPGDSDLD QLTRIFETLG TPTEEQWPDM
       250        260        270        280        290        300
CSLPDYVTFK SFPGVPLQHI FIAAGDDLLE LIQGLFLFNP CTRTTASQAL KTKYFSNRPG
       310        320        330        340
PTPGCQLPRP NCPVEALKEP ANPTVATKRK RAEALEQGIL PKKLIF 

Encoded by Cdk7 gene

FULL NAME: cyclin-dependent kinase 7


OTHER NAME(S):
AI323415
AI528512
C230069N13
Cdkn7
Crk4


Nucleic acid sequence

        10         20         30         40         50         60
atggctgtgg acgtgaagtc tcgagcgaag cgctatgaga aactggactt cctcggagag
        70         80         90        100        110        120
ggacagtttg cgacggtcta taaggccagg gacaagaaca ccaaccaaat cgtcgccatt
       130        140        150        160        170        180
aagaaaatca aacttggaca caggtcagaa gctaaggatg gaataaatag aacagcctta
       190        200        210        220        230        240
agggagataa agctcttaca ggaactaagt catccaaata taattggtct ccttgatgca
       250        260        270        280        290        300
tttggacata agtctaacat tagccttgtc tttgatttta tggaaactga cctcgaggtt
       310        320        330        340        350        360
attataaagg ataacagcct tgtgctgaca ccatcccaca ttaaagccta catgttgatg
       370        380        390        400        410        420
actcttcagg gcttagaata tttacatcag cattggattc tacacaggga tctgaaacca
       430        440        450        460        470        480
aacaacttgt tgttagatga gaatggagtt ctgaaactgg cagattttgg cctggccaaa
       490        500        510        520        530        540
tcatttggga gccccaatag ggcttacaca catcaagttg tgaccagatg gtaccgggct
       550        560        570        580        590        600
cctgagttat tgtttggagc taggatgtat ggtgtgggag tagacatgtg ggctgttggt
       610        620        630        640        650        660
tgtatattag cagaattgct tctaagggtt ccatttttgc ctggagattc agatcttgat
       670        680        690        700        710        720
cagctaacaa ggatatttga aactctgggt acaccaactg aagagcagtg gcctgacatg
       730        740        750        760        770        780
tgtagtcttc ccgattatgt gacatttaag agtttccctg gggtcccact gcagcacatc
       790        800        810        820        830        840
ttcatcgcgg ctggggacga cctgctggag ctcatccaag gcctgttctt atttaacccg
       850        860        870        880        890        900
tgtacgcgga ccacagcctc acaggcattg aagaccaagt acttcagtaa ccgccccggg
       910        920        930        940        950        960
ccaacacctg gatgccagct cccgcgacca aactgtccgg tggaggcatt aaaggaaccg
       970        980        990       1000       1010       1020
gcgaatccaa ccgtggcaac aaagcggaaa agagcagagg ccttagaaca aggaatattg
      1030       1040
cccaagaagc tcatttttta g   

Last modification date: Oct. 2, 2011