Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Transcription initiation factor TFIID subunit 12


DESCRIPTION:
Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation (gcn5) and deubiquitination (ubp8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3 (By similarity).

STRUCTURE SIMILARITY:
Contains 1 histone-fold domain.
Belongs to the TAF12 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MNGQHSSPGT PVQRPSAGPV NQAQFSQQRT NQLTSLLHTM TMYQQLAQNV GLNTPQGQVY
        70         80         90        100        110        120
LLQAQTIRRQ LQGHAQSGQL PNQQLLQQLQ SNGALQQGTP EPSNTRPRPQ LNAQEQTMLL
       130        140        150        160        170        180
VRHRQLQTAQ NYLTEMKEAL GRIKNELSTN ERLDTSAREA LVKQESELTV KIAQFTAAIS
       190        200        210        220        230        240
NGIRSIQQLQ NRQASSANGN NTGTSTPVNA STDTRKSTAS TPQLQQTQAQ ANAPQQRINP
       250        260        270        280        290        300
ETSSVPETPV GVSAANVSNE STELATSATQ QSGLANNVEK SQTPSYMSAN HLPKVDSKSP
       310        320        330        340        350        360
IPFSVPPSRA TLTGGYASGS IGLSTPGLSR APHYELDNGN RLLSKRKLHD LLQQIDSEEK
       370        380        390        400        410        420
IEPEVEELLL EIADEFVESV TNFACRLAKH RKSDTLDVRD VQLHLERNWN IRLPGFASDD
       430        440        450
IVKSARKTGP TPSYQQKQNA IGTAKSLNKD   

Encoded by taf12 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgaatgggc agcattcaag ccctggaaca ccagttcaac gaccatctgc tggaccggta
        70         80         90        100        110        120
aatcaggcac aattttcaca acagagaacg aaccagttaa catctttgtt acacactatg
       130        140        150        160        170        180
actatgtatc agcaacttgc tcaaaacgtt ggccttaata ctcctcaggg acaagtttat
       190        200        210        220        230        240
ttgcttcaag ctcaaaccat tcgtcgtcaa ttacaaggcc acgcgcaatc tggacaactt
       250        260        270        280        290        300
ccaaatcaac aactcttaca acaattacaa tccaatggag ctcttcagca aggtactccg
       310        320        330        340        350        360
gagccttcaa atacccgccc gcgacctcag ttgaatgctc aagaacaaac aatgctttta
       370        380        390        400        410        420
gtcaggcata ggcaactcca aactgctcag aactacttaa cagaaatgaa agaggcttta
       430        440        450        460        470        480
ggtcgcatta aaaacgaact ttctacaaat gaaagattgg acactagtgc tcgcgaggct
       490        500        510        520        530        540
ttggtaaagc aggagtccga gttgactgta aaaatcgcgc aatttaccgc tgccatttct
       550        560        570        580        590        600
aacggcattc gttccattca acaattacaa aataggcagg catcttctgc taacggtaat
       610        620        630        640        650        660
aatactggta catcaactcc tgtgaacgcc tcaactgata ctagaaaaag cactgcttca
       670        680        690        700        710        720
actcctcaat tacaacagac ccaagcacaa gctaatgctc ctcaacaacg tataaatccc
       730        740        750        760        770        780
gagacgtctt ctgttcctga aactcctgtt ggcgtttccg cagctaatgt tagcaatgaa
       790        800        810        820        830        840
agtaccgagc tcgctacttc tgcaactcaa cagtcgggtt tggcaaataa cgttgaaaag
       850        860        870        880        890        900
tcacaaactc cttcttacat gtcagcgaac catttaccca aggttgactc caaatcacca
       910        920        930        940        950        960
ataccgtttt ctgttcctcc gagtcgtgct acattaactg gtggatatgc atctggaagt
       970        980        990       1000       1010       1020
attggtctca gcacaccggg attatctcgt gctccacact acgagcttga caatggaaac
      1030       1040       1050       1060       1070       1080
cggttattat caaagagaaa attgcatgat ttgctacagc aaattgactc ggaagagaaa
      1090       1100       1110       1120       1130       1140
atagaaccag aagttgaaga actcctttta gagattgctg atgagtttgt cgaatcagtc
      1150       1160       1170       1180       1190       1200
actaattttg catgcagact tgctaaacat agaaaatctg atacgcttga cgtaagagat
      1210       1220       1230       1240       1250       1260
gttcaattgc atttagaaag gaactggaac atccgactcc ctgggtttgc tagtgatgat
      1270       1280       1290       1300       1310       1320
atcgtcaaga gcgctcgtaa gactgggccc acaccttcat atcagcaaaa gcaaaacgct
      1330       1340       1350
attggaactg ctaaaagttt gaataaggac taa  

Last modification date: Oct. 2, 2011