Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor TFIID subunit 12


DESCRIPTION:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

STRUCTURE SIMILARITY:
Contains 1 histone-fold domain.
Belongs to the TAF12 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MNQFGPSALI NLSNFSSIKP EPASTPPQGS MANSTAVVKI PGTPGAGGRL SPENNQVLTK
        70         80         90        100        110        120
KKLQDLVREV DPNEQLDEDV EEMLLQIADD FIESVVTAAC QLARHRKSST LEVKDVQLHL
       130        140        150        160
ERQWNMWIPG FGSEEIRPYK KACTTEAHKQ RMALIRKTTK K 

Encoded by TAF12 gene

FULL NAME: TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa


OTHER NAME(S):
TAF2J
TAFII20


DESCRIPTION:
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgaaccagt ttggcccctc agccctaatc aacctctcca atttctcatc cataaaaccg
        70         80         90        100        110        120
gaaccagcca gcacccctcc acaaggctcc atggccaata gtactgcagt ggtaaagata
       130        140        150        160        170        180
ccaggcactc ctggggcagg aggtcgtctt agccctgaaa acaatcaggt attgaccaag
       190        200        210        220        230        240
aagaaattac aggacttagt aagagaagtg gatcctaatg agcagttgga tgaagatgtg
       250        260        270        280        290        300
gaggagatgc tgctgcagat tgctgatgat tttatcgaga gtgtggtgac agcagcctgt
       310        320        330        340        350        360
cagcttgcgc ggcatcgcaa gtctagcacc ctggaggtga aagatgtcca gctgcattta
       370        380        390        400        410        420
gagcgccagt ggaacatgtg gatcccagga tttggctctg aagaaatccg accctacaaa
       430        440        450        460        470        480
aaagcttgca ccacagaagc tcacaaacag agaatggcat tgatccggaa aacaaccaag

aaataa     

Last modification date: Oct. 2, 2011