Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor IIB


DESCRIPTION:
General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

STRUCTURE SIMILARITY:
Contains 1 TFIIB-type zinc finger.
Belongs to the TFIIB family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA
        70         80         90        100        110        120
TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE
       130        140        150        160        170        180
ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI
       190        200        210        220        230        240
CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV
       250        260        270        280        290        300
ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF
       310
PTDFKFDTPV DKLPQL    

Encoded by GTF2B gene

FULL NAME: general transcription factor IIB


OTHER NAME(S):
TF2B
TFIIB


DESCRIPTION:
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcgtcta ccagccgttt ggatgctctt ccaagagtca catgtccaaa ccatccagat
        70         80         90        100        110        120
gcgattttag tggaggacta cagagccggt gatatgatct gtcctgaatg tggcttggtt
       130        140        150        160        170        180
gtaggtgacc gggttattga tgtgggatct gaatggcgaa ctttcagcaa tgacaaagca
       190        200        210        220        230        240
acaaaagatc catctcgagt tggagattct cagaatcctc ttctgagtga tggagatttg
       250        260        270        280        290        300
tctaccatga ttggcaaggg cacaggagct gcaagttttg acgaatttgg caattctaag
       310        320        330        340        350        360
taccagaatc ggagaacaat gagcagttct gatcgggcaa tgatgaatgc attcaaagaa
       370        380        390        400        410        420
atcactacca tggcagacag aatcaatcta cctcgaaata tagttgatcg aacaaataat
       430        440        450        460        470        480
ttattcaagc aagtatatga acagaagagc ctgaagggaa gagctaatga tgctatagct
       490        500        510        520        530        540
tctgcttgtc tctatattgc ctgtagacaa gaaggggttc ctaggacatt taaagaaata
       550        560        570        580        590        600
tgtgccgtat cacgaatttc taagaaagaa attggtcggt gttttaaact tattttgaaa
       610        620        630        640        650        660
gcgctagaaa ccagtgtgga tttgattaca actggggact tcatgtccag gttctgttcc
       670        680        690        700        710        720
aacctttgtc ttcctaaaca agtacagatg gcagctacac atatagcccg taaagctgtg
       730        740        750        760        770        780
gaattggact tggttcctgg gaggagcccc atctctgtgg cagcggcagc tatttacatg
       790        800        810        820        830        840
gcctcacagg catcagctga aaagaggacc caaaaagaaa ttggagatat tgctggtgtt
       850        860        870        880        890        900
gctgatgtta caatcagaca gtcctataga ctgatctatc ctcgagcccc agatctgttt
       910        920        930        940        950
cctacagact tcaaatttga caccccagtg gacaaactac cacagctata a

Last modification date: Oct. 2, 2011