Mus musculus L. (mouse) [MMU]

FULL NAME: Centrin-2


DESCRIPTION:
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (By similarity).
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Rad23b appears to stabilize Xpc. In vitro, stimulates DNA binding of the Xpc:Rad23b dimer (By similarity).
Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110 (By similarity).

MISCELLANEOUS:
Binds two moles of calcium per mole of protein (By similarity).


STRUCTURE SIMILARITY:
Contains 4 EF-hand domains.
Belongs to the centrin family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MASNFKKTTM ASSAQRKRMS PKPELTEDQK QEIREAFDLF DADGTGTIDI KELKVAMRAL
        70         80         90        100        110        120
GFEPKKEEIK KMISEIDKEG TGKMNFSDFL TVMTQKMSEK DTKEEILKAF KLFDDDETGK
       130        140        150        160        170
ISFKNLKRVA KELGENLTDE ELQEMIDEAD RDGDGEVNEQ EFLRIMKKTS LY

Encoded by Cetn2 gene

FULL NAME: centrin 2


OTHER NAME(S):
1110034A02Rik
AI326150
Calt
caltractin


Nucleic acid sequence

        10         20         30         40         50         60
atggcctcta attttaagaa gacaaccatg gcatccagtg cccagagaaa aaggatgagt
        70         80         90        100        110        120
cctaagcctg aacttactga agaccagaaa caggaaatcc gggaagcttt tgatctcttt
       130        140        150        160        170        180
gatgctgatg gaactggaac tatagacatc aaagaactga aggtggcaat gagggccctg
       190        200        210        220        230        240
ggctttgagc ccaagaaaga agaaattaag aaaatgataa gtgaaattga taaagaagga
       250        260        270        280        290        300
acaggaaaaa tgaacttcag tgactttttg acagtgatga ctcagaaaat gtctgagaaa
       310        320        330        340        350        360
gacactaaag aagaaatcct gaaagctttc aagttgttcg atgatgatga gactgggaaa
       370        380        390        400        410        420
atatcattca agaatcttaa gcgcgtggcc aaggagctgg gtgagaacct gacagatgag
       430        440        450        460        470        480
gaactgcagg aaatgattga tgaagctgat cgagatggag atggtgaggt caatgagcaa
       490        500        510
gagttcctgc gcatcatgaa aaagaccagc ctctattaa  

Last modification date: Oct. 2, 2011