Mus musculus L. (mouse) [MMU]

FULL NAME: UV excision repair protein RAD23 homolog B


DESCRIPTION:
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the Xpc:Rad23b dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. Xpc:Rad23b contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. Xpc:Rad23bB induces a bend in DNA upon binding. Xpc:Rad23b stimulates the activity of DNA glycosylases Tdg and Smug1 (By similarity).
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmatic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with Cetn2 appears to stabilize Xpc. May protect Xpc from proteasomal degradation (By similarity).

STRUCTURE SIMILARITY:
Contains 1 STI1 domain.
Belongs to the RAD23 family.
Contains 2 UBA domains.
Contains 1 ubiquitin-like domain.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILSDDTALK
        70         80         90        100        110        120
EYKIDEKNFV VVMVTKPKAV TTAVPATTQP SSTPSPTAVS SSPAVAAAQA PAPTPALPPT
       130        140        150        160        170        180
STPASTAPAS TTASSEPAPA GATQPEKPAE KPAQTPVLTS PAPADSTPGD SSRSNLFEDA
       190        200        210        220        230        240
TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD
       250        260        270        280        290        300
PPPQAVSTGT PQSPAVAAAA ATTTATTTTT SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP
       310        320        330        340        350        360
ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGSQGG GGGGGGGGGG GGGGGIAEAG
       370        380        390        400        410
SGHMNYIQVT PQEKEAIERL KALGFPEGLV IQAYFACEKN ENLAANFLLQ QNFDED

Encoded by Rad23b gene

FULL NAME: RAD23b homolog (S. cerevisiae)


OTHER NAME(S):
0610007D13Rik
AV001138
HR23B
mHR23B
p58


Nucleic acid sequence

        10         20         30         40         50         60
atgcaggtca ccctgaagac ccttcagcag cagaccttca agatcgacat cgacccggag
        70         80         90        100        110        120
gagacggtaa aggcattgaa agagaagatt gaatctgaaa aggggaaaga tgcctttccg
       130        140        150        160        170        180
gtagcaggtc agaagttaat ttatgcaggc aaaatcctca gtgatgatac tgctctcaaa
       190        200        210        220        230        240
gaatataaaa ttgatgagaa aaactttgtg gtggttatgg tgacaaaacc caaagcagtg
       250        260        270        280        290        300
accacagcag tgccagctac aacccagcca tcaagtactc ccagccccac tgcagtcagt
       310        320        330        340        350        360
tcttccccag cagtggctgc ggcccaggct ccagctccca cccctgctct gcctcccact
       370        380        390        400        410        420
tccactcctg cctccactgc tccagcctcc actacagcct cttctgaacc cgcacctgct
       430        440        450        460        470        480
ggtgccactc agcctgagaa acctgcagaa aagccagccc agacaccagt gcttactagc
       490        500        510        520        530        540
ccagcaccag ctgacagtac accaggagat tcttcccggt caaatctttt tgaagatgca
       550        560        570        580        590        600
acaagtgccc ttgtgacagg tcagtcttat gagaatatgg taactgagat catgtcaatg
       610        620        630        640        650        660
ggctatgaac gagaacaagt aattgcagcc ctgagagcca gcttcaacaa ccctgacaga
       670        680        690        700        710        720
gctgtggaat atcttctaat gggaatccct ggagatagag aaagtcaggc tgtggttgac
       730        740        750        760        770        780
cctcctcctc aggctgtgag tactggaact cctcagtctc cagcagtagc tgcagctgca
       790        800        810        820        830        840
gcaaccacga cagcaactac aacaaccact tctggaggcc acccccttga atttttacgg
       850        860        870        880        890        900
aatcagcctc agtttcaaca gatgagacaa attatccagc agaatccttc tttgctgcca
       910        920        930        940        950        960
gccttgctac agcagatagg tcgggagaac cctcagctgc tgcagcaaat tagccaacac
       970        980        990       1000       1010       1020
caggagcatt ttattcagat gctgaatgaa ccagttcagg aagcaggcag tcaaggtgga
      1030       1040       1050       1060       1070       1080
ggaggtggtg gcggaggagg cggtggcgga ggaggcggtg gaggaattgc agaagctgga
      1090       1100       1110       1120       1130       1140
agtgggcaca tgaattacat tcaagtaaca cctcaggaga aagaagctat agaacggtta
      1150       1160       1170       1180       1190       1200
aaggcattag gatttcctga aggacttgtg attcaagcat attttgcttg tgagaagaat
      1210       1220       1230       1240       1250
gagaatctgg ctgccaactt tcttctacag cagaactttg atgaagactg a

Last modification date: Oct. 2, 2011