Homo sapiens L. (human) [HSA]

FULL NAME: Transcription initiation factor IIA subunit 1


DESCRIPTION:
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

STRUCTURE SIMILARITY:
Belongs to the TFIIA subunit 1 family.


POST-TRANSLATIONAL MODIFICATION:
The alpha and beta subunits are postranslationally produced from the precursor form by TASP1. The cleavage promotes proteasomal degradation.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MANSANTNTV PKLYRSVIED VINDVRDIFL DDGVDEQVLM ELKTLWENKL MQSRAVDGFH
        70         80         90        100        110        120
SEEQQLLLQV QQQHQPQQQQ HHHHHHHQQA QPQQTVPQQA QTQQVLIPAS QQATAPQVIV
       130        140        150        160        170        180
PDSKLIQHMN ASNMSAAATA ATLALPAGVT PVQQILTNSG QLLQVVRAAN GAQYIFQPQQ
       190        200        210        220        230        240
SVVLQQQVIP QMQPGGVQAP VIQQVLAPLP GGISPQTGVI IQPQQILFTG NKTQVIPTTV
       250        260        270        280        290        300
AAPTPAQAQI TATGQQQPQA QPAQTQAPLV LQVDGTGDTS SEEDEDEEED YDDDEEEDKE
       310        320        330        340        350        360
KDGAEDGQVE EEPLNSEDDV SDEEGQELFD TENVVVCQYD KIHRSKNKWK FHLKDGIMNL
       370
NGRDYIFSKA IGDAEW    

Encoded by GTF2A1 gene

FULL NAME: general transcription factor IIA, 1, 19/37kDa


OTHER NAME(S):
MGC129969
MGC129970
TF2A1
TFIIA


DESCRIPTION:
Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atggcgaact cggcaaatac aaacaccgtg cctaaattat acagatctgt gattgaagat
        70         80         90        100        110        120
gtcattaatg atgtgagaga catctttctg gatgatggag tggatgaaca agtactgatg
       130        140        150        160        170        180
gaactaaaaa ctttatggga aaacaaacta atgcagtcca gggcagtaga tggatttcat
       190        200        210        220        230        240
tcagaagagc agcagcttct actgcaagtt caacagcagc atcaacccca gcagcagcag
       250        260        270        280        290        300
catcaccacc atcaccatca tcagcaagct cagcctcagc agacagtacc tcagcaagcg
       310        320        330        340        350        360
cagacccagc aggttcttat tcctgcatca cagcaagcca cagcaccaca agttattgtt
       370        380        390        400        410        420
ccagattcta agttgataca gcatatgaat gcatcaaaca tgagtgctgc tgctacagct
       430        440        450        460        470        480
gctaccttag cactccctgc aggtgtgact cctgttcagc agatattaac aaattcaggc
       490        500        510        520        530        540
cagcttcttc aggtggtcag agcagccaat ggtgcccaat atatctttca gcctcagcag
       550        560        570        580        590        600
tcagtggttc tacaacaaca ggttatacca caaatgcagc ctggtggagt acaagctcct
       610        620        630        640        650        660
gttatacagc aggtgctggc tcctcttcct ggagggattt caccacagac aggtgtcatc
       670        680        690        700        710        720
atccagcctc agcaaatctt atttacagga aataagactc aagttatacc tacgacagtg
       730        740        750        760        770        780
gcagcaccta caccagccca agcacagata actgcaactg gccagcagca accgcaggcc
       790        800        810        820        830        840
cagcctgctc aaacacaagc tccattggtc ttacaagttg atggaactgg ggatacatca
       850        860        870        880        890        900
tctgaagaag atgaagatga agaagaagac tatgatgatg atgaggagga agacaaagag
       910        920        930        940        950        960
aaagatggag ctgaagatgg gcaggtggaa gaagagcccc tcaatagtga agatgatgtg
       970        980        990       1000       1010       1020
agtgatgagg aaggacagga actctttgac acagaaaatg ttgttgtatg ccaatatgat
      1030       1040       1050       1060       1070       1080
aagatacaca gaagtaaaaa caaatggaaa tttcatctca aggatggcat tatgaatctt
      1090       1100       1110       1120       1130
aatggaagag attatatatt ttccaaagcc attggagatg cagaatggtg a

Last modification date: Oct. 2, 2011