Homo sapiens L. (human) [HSA]

FULL NAME: TFIIA-alpha and beta-like factor


DESCRIPTION:
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.

STRUCTURE SIMILARITY:
Belongs to the TFIIA subunit 1 family.


RELATED PATHWAY(S):
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MACLNPVLWE TKVLQSKATE DFFRNSIQSP LFTLQLPHSL HQTLQSSTAS LVIPAGRTLP
        70         80         90        100        110        120
SFTTAELGTS NSSANFTFPG YPIHVPAGVT LQTVSGHLYK VNVPIMVTET SGRAGILQHP
       130        140        150        160        170        180
IQQVFQQLGQ PSVIQTSVPQ LNPWSLQATT EKSQRIETVL QQPAILPSGP VDRKHLENAT
       190        200        210        220        230        240
SDILVSPGNE HKIVPEALLC HQESSHYISL PGVVFSPQVS QTNSNVESVL SGSASMAQNL
       250        260        270        280        290        300
HDESLSTSPH GALHQHVTDI QLHILKNRMY GCDSVKQPRN IEEPSNIPVS EKDSNSQVDL
       310        320        330        340        350        360
SIRVTDDDIG EIIQVDGSGD TSSNEEIGST RDADENEFLG NIDGGDLKVP EEEADSISNE
       370        380        390        400        410        420
DSATNSSDNE DPQVNIVEED PLNSGDDVSE QDVPDLFDTD NVIVCQYDKI HRSKNKWKFY
       430        440
LKDGVMCFGG RDYVFAKAIG DAEW   

Encoded by GTF2A1L gene

FULL NAME: general transcription factor IIA, 1-like


OTHER NAME(S):
ALF
MGC26254


DESCRIPTION:
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcctgcc tcaacccggt gctctgggaa accaaggttt tgcagtctaa agcaacagaa
        70         80         90        100        110        120
gacttcttca gaaatagcat ccaatcacct ctgtttactc ttcagttgcc gcacagcttg
       130        140        150        160        170        180
caccaaacat tgcaatcgtc aacagcatca ttagttattc ctgctggtag aactcttcca
       190        200        210        220        230        240
agttttacca cagcagaact gggcacttca aactccagtg caaactttac ttttcctggt
       250        260        270        280        290        300
tatcccattc atgtaccagc aggtgtgaca ctacagactg tatctggtca cctttataaa
       310        320        330        340        350        360
gtcaatgtac caattatggt gacagagact tctggaagag caggtattct tcagcatcca
       370        380        390        400        410        420
attcagcaag tatttcaaca gcttggccag ccttcagtaa tacaaactag tgttccacaa
       430        440        450        460        470        480
ttgaatccat ggtctcttca agcaactact gaaaaatcac agagaattga aaccgtgcta
       490        500        510        520        530        540
cagcaacccg caattctacc ttctgggcca gtagatagga aacacttaga aaatgccacc
       550        560        570        580        590        600
agtgatatac ttgtatctcc tggaaatgag cataaaatcg tgcctgaagc tttgttgtgt
       610        620        630        640        650        660
catcaggaaa gttctcacta tatcagtctt ccaggtgttg tattttctcc acaggtctct
       670        680        690        700        710        720
caaacaaatt ctaatgtgga gtcagtgctc agtggttcag ctagcatggc tcaaaatctg
       730        740        750        760        770        780
catgatgagt ccctctccac aagccctcat ggggctctcc accagcacgt gactgatatt
       790        800        810        820        830        840
cagcttcata ttcttaaaaa taggatgtat ggatgtgatt ctgtaaagca accaagaaat
       850        860        870        880        890        900
atagaggaac ccagcaacat acctgtatca gagaaggatt ctaattctca ggtggattta
       910        920        930        940        950        960
agcattcggg ttactgatga tgatattggt gaaataattc aagtagatgg aagcggtgat
       970        980        990       1000       1010       1020
acatcttcca atgaagaaat aggaagtaca agagatgcag atgagaatga atttctaggg
      1030       1040       1050       1060       1070       1080
aatattgacg ggggagatct gaaggtacct gaagaagaag ctgacagtat ttcaaatgag
      1090       1100       1110       1120       1130       1140
gattcagcca caaacagtag tgataatgaa gaccctcaag taaacattgt agaagaggac
      1150       1160       1170       1180       1190       1200
cctttaaatt ctggagatga tgttagtgaa caggatgtgc cagacctgtt tgacacggat
      1210       1220       1230       1240       1250       1260
aatgttattg tctgtcagta tgataagatt catcgaagca agaacaaatg gaaattctat
      1270       1280       1290       1300       1310       1320
ttgaaagatg gtgttatgtg ttttggaggg agagactatg tatttgcaaa agccattggt
      1330
gatgcagagt ggtaa    

Last modification date: Oct. 2, 2011